Sleep and Brain Activity

Sleep and Brain Activity

1st Edition - July 18, 2012
  • Editor: Marcos G. Frank
  • eBook ISBN: 9780123849960
  • Hardcover ISBN: 9780123849953

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In the last few decades, scientists have discovered that far from being a time of neural silence, sleep is characterized by complex patterns of electrical, neurochemical, and metabolic activity in the brain. Sleep and the Brain presents some of the more dramatic developments in our understanding of brain activity in sleep. The book discusses what parts of the brain are active in sleep and how, and presents research on the function of sleep in memory, learning, and further brain development. Coverage encompasses the network and membrane mechanisms responsible for waking and sleeping brain activity, the roles of glial cells in the sleeping brain, the molecular basis of sleep EEG rhythms, and research on songbirds, rodents, and humans indicating the function of sleep.

Key Features

  • Collates material dispersed across a wide gamut of primary literature into one place
  • Focuses on the most interesting and prolific research results on brain activity as it relates to sleep
  • Practical real data discussion includes functional brain imaging and EEG research


Neuroscientists and psychologists studying sleep and/or brain activity

Table of Contents

  • Preface

    List of Contributors

    Chapter 1. Neuronal Oscillations in the Thalamocortical System during Sleeping and Waking States

    Neuronal Synchronization

    Basic Thalamocortical States

    Thalamocortical Rhythmic Activities

    Origin of Slow Waves: Cortex versus Thalamus

    Origin of Slow Waves: Horizontal and Vertical Propagation



    Chapter 2. Corticothalamic Rhythms during States of Reduced Vigilance

    The Alpha Rhythm of Relaxed Wakefulness and the Theta Waves of Early NREM Sleep

    The Slow (<1 Hz) EEG Rhythm of NREM Sleep

    Concluding Remarks



    Chapter 3. Glial Modulation of Sleep and Electroencephalographic Rhythms


    Early Concepts of Glial Roles in Sleep

    Glia, Neural Metabolism, and Sleep

    Ion Buffering and EEG Activity

    Glial Secretion of Somnogenic Substances: Astrocytes

    Glial Secretion of Somnogenic Substances: Microglia and Oligodendrocytes

    Unanswered Questions and Future Directions


    Chapter 4. Genetic Mechanisms Underlying Rhythmic EEG Activity during Sleep


    Genetics of the Human EEG: Twin, Linkage, and Candidate-Gene Studies

    Genetics of the EEG: Mouse Studies

    Regulation of Sleep: Time-of-Day versus Time-Spent-Awake

    Genetics of the Homeostatic Regulation of Sleep

    A Non-Circadian Role for Clock Genes in Sleep Homeostasis


    Chapter 5. Evoked Electrophysiological and Vascular Responses across Sleep


    Electrical Markers of Sleep and Sleepiness

    Evoked Vascular and Hemodynamic Relationships to Sleep




    Chapter 6. Sleep and Learning in Birds

    Sleep Research from the Ethological Perspective

    The Organization of Sleep in Birds

    Towards an Animal Model: Sleep-Dependent Memory Consolidation in Humans

    The Hippocampal System and Sleep-Dependent Memory Consolidation: Limited Evidence of Behavioral Consequences

    European Starlings and Sleep-Dependent Memory Consolidation: Behavior

    Functional Organization of the Starling Auditory System

    An Introduction to Birdsong Production Learning and the Role of Sleep

    The Bird Song System

    Neuronal Replay in the Song System

    Neuronal Replay in Adult Song Birds

    Sleep and Sensorimotor Song Learning: Behavioral Evidence

    Neuronal Replay and Song Development

    Old and New Ideas Regarding Sleep in a New Theory of Song Learning

    Summary and Final Conclusions


    Chapter 7. Phasic Pontine-Wave (P-Wave) Generation


    Description of PGO/P-Waves

    Cellular and Molecular Characteristics of the PGO/P-Wave Generator

    Mechanisms of P-Wave Activity Generation

    Evidence to Link the P-Wave Generator with Memory Consolidation




    Chapter 8. Neural Correlates of Human Sleep and Sleep-Dependent Memory Processing


    NREM Sleep

    REM Sleep

    Functional Neuroimaging of Memory Processing during Sleep




    Chapter 9. Sleep EEG Rhythms and System Consolidation of Memory

    Memory and Sleep

    Mechanisms of Sleep-Dependent Memory Consolidation

    Concluding Remarks



    Chapter 10. Sleep Slow Oscillations and Cortical Maturation

    Slow Waves and Sleep Homeostasis

    Slow Wave Sleep is the Price Paid for Plasticity in a Complex Neural System

    The Development of Slow Waves Parallels Cortical Maturation

    Active Role of Slow Waves?

    Translation into Clinics



Product details

  • No. of pages: 288
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: July 18, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123849960
  • Hardcover ISBN: 9780123849953

About the Editor

Marcos G. Frank

Marcos Frank's research investigates the mystery of sleep function to understand one of the most persistent and perplexing questions of all time – why animals sleep, or put another way, why the brain needs sleep. Building on his research that the brain during sleep is fundamentally different from the brain during wakefulness, he has found that cellular changes in the sleeping brain may promote the formation of memories. He received a doctoral degree at Stanford University in 1997, and did his post-doctoral research in the Department of Physiology at the University of California at San Francisco.