Single-cell Omics

Single-cell Omics: Technological Advances and Applications provides the latest technological developments and the applications of single-cell technologies in the field of biomedicine. The advent of omics technologies have enable us to identify the differences between cell types and subpopulations at the level of the genome, proteome, transcriptome, epigenome, and in several other fields of omics. In the current era of precision medicine, the single-cell omics technology is highly promising due to its potential in diagnosis, prognosis, and therapeutics.

The book is divided in five parts: the first one brings an overview of single-cell omics researches and applications; the second deals with the diverse technologies applied in the topic, such as pangenomics, metabolomics, and multi-omics of single cells; the third is dedicated to data analysis; the forth one discusses the several applications of single-cell omics within biomedical field, for example in cancer, metabolic and neuro diseases, immunology, pharmacogenomics, personalized medicine and reproductive health; and a final discussion on future perspectives.

This book is a valuable source for bioinformaticians, molecular diagnostic researchers, clinicians and several members of biomedical field interested in understanding more about single-cell omics and its potential for research and diagnosis.

• Covers not only the technological aspects, but also the diverse applications of single cell omics to biomedical field
• Summarizes the latest progresses in single cell omics and discusses potential future developments for research and diagnosis
• Written by experts across the world, it brings different points of view and study cases to fully give a comprehensive overview of the topic

Bioinformaticians, molecular diagnostic researchers, clinicians, geneticists

I. Introduction
1. Single Cell Omics: An overview
2. Cellular heterogeneity and Single Cell Omics
3. Single Cell Omics: Cellular functions
4. Single Cell Omics: Clonal expansion

II. Single Cell Technologies: An omics perspective
5. Single-Cell Genomics: Technology and applications
6. Pangenomics in Single-Cell Omics
7. Single-Cell Epigenomics: Technology and applications
8. Single-Cell Transcriptomics: Technology and applications
9. Single-Cell Proteomics: Technology and applications
10. Single Cell Metabolomics: Technology and applications
11. Multi-Omics of Single Cells

III. Data analysis in Single Cell Omics
11. Quality control in Single Cell Omics
12. Metagenomics and Single-Cell Omics
13. Bioinformatics/ Computational Single Cell Omics

IV. Single Cell Omics: Biomedical applications
14. Single Cell Diagnostics, prognosis, and therapy: Overview
16. Single Cell Omics and Cancer
17. Circulating tumor cells: Technologies and applications
18. Single Cell Omics and CVDs
19. Single Cell Omics and Metabolic Diseases
20. Single Cell Omics in Neurological, Psychiatric and Psychological
21. Single Cell Omics in Immunology
22. Single Cell Omics in Reproductive health
23. Circulating fetal Cells: Applications in NIPT
24. Single Cell Omics in Preventive medicine
25. Single Cell Omics in Personalized medicine
26. Single-cell Omics for drug discovery and development
27. Single Cell Omics in Pharmacogenomics
28. Cell based medicine/therapy
29. Recent progress in single-cell omics