Single-cell Omics - 1st Edition - ISBN: 9780128149195

Single-cell Omics

1st Edition

Technological Advances and Applications

Editors: Debmalya Barh Vasco Azevedo
Paperback ISBN: 9780128149195
Imprint: Academic Press
Published Date: 1st August 2019
Page Count: 600
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Description

Single-cell Omics: Technological Advances and Applications provides the latest technological developments and the applications of single-cell technologies in the field of biomedicine. The advent of omics technologies have enable us to identify the differences between cell types and subpopulations at the level of the genome, proteome, transcriptome, epigenome, and in several other fields of omics. In the current era of precision medicine, the single-cell omics technology is highly promising due to its potential in diagnosis, prognosis, and therapeutics.

The book is divided in five parts: the first one brings an overview of single-cell omics researches and applications; the second deals with the diverse technologies applied in the topic, such as pangenomics, metabolomics, and multi-omics of single cells; the third is dedicated to data analysis; the forth one discusses the several applications of single-cell omics within biomedical field, for example in cancer, metabolic and neuro diseases, immunology, pharmacogenomics, personalized medicine and reproductive health; and a final discussion on future perspectives.

This book is a valuable source for bioinformaticians, molecular diagnostic researchers, clinicians and several members of biomedical field interested in understanding more about single-cell omics and its potential for research and diagnosis.

Key Features

  • Covers not only the technological aspects, but also the diverse applications of single cell omics to biomedical field
  • Summarizes the latest progresses in single cell omics and discusses potential future developments for research and diagnosis
  • Written by experts across the world, it brings different points of view and study cases to fully give a comprehensive overview of the topic

Readership

Bioinformaticians, molecular diagnostic researchers, clinicians, geneticists

Table of Contents

I. Introduction
1. Single Cell Omics: An overview
2. Cellular heterogeneity and Single Cell Omics
3. Single Cell Omics: Cellular functions
4. Single Cell Omics: Clonal expansion

II. Single Cell Technologies: An omics perspective
5. Single-Cell Genomics: Technology and applications
6. Pangenomics in Single-Cell Omics
7. Single-Cell Epigenomics: Technology and applications
8. Single-Cell Transcriptomics: Technology and applications
9. Single-Cell Proteomics: Technology and applications
10. Single Cell Metabolomics: Technology and applications
11. Multi-Omics of Single Cells

III. Data analysis in Single Cell Omics
11. Quality control in Single Cell Omics
12. Metagenomics and Single-Cell Omics
13. Bioinformatics/ Computational Single Cell Omics

IV. Single Cell Omics: Biomedical applications
14. Single Cell Diagnostics, prognosis, and therapy: Overview
16. Single Cell Omics and Cancer
17. Circulating tumor cells: Technologies and applications
18. Single Cell Omics and CVDs
19. Single Cell Omics and Metabolic Diseases
20. Single Cell Omics in Neurological, Psychiatric and Psychological
21. Single Cell Omics in Immunology
22. Single Cell Omics in Reproductive health
23. Circulating fetal Cells: Applications in NIPT
24. Single Cell Omics in Preventive medicine
25. Single Cell Omics in Personalized medicine
26. Single-cell Omics for drug discovery and development
27. Single Cell Omics in Pharmacogenomics
28. Cell based medicine/therapy
29. Recent progress in single-cell omics

Details

No. of pages:
600
Language:
English
Copyright:
© Academic Press 2019
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128149195

About the Editor

Debmalya Barh

M.Sc. (Applied Genetics), M.Tech. (Biotechnology), M.Phil. (Biotechnology), Ph.D. (Biotechnology), Ph.D. (Bioinformatics), Post-Doc (Bioinformatics), PGDM, is honorary Principal Scientist at Institute of Integrative Omics and Applied Biotechnology (IIOAB), India- a virtual global platform of multidicipliary research and advocacy. He is blended with both academic and industrial research and has more than 12 yrs bioinformatics and personalized diagnostic/ medicine Industry experience where his main focus is to translate academic research into high value commercial products for common mans’ reach. He has published more than 150 articles in reputed international journals and has edited 15 cutting-edge omics related reference books published by Taylor& Francis, Springer, Elsevier etc. He has also co-authored 30+ book chapters. Dr. Barh also frequently reviewes articles for Nature publications, Elsevier, BMC Series, PLoS One etc like international Journals. Due to his significant contribution in the field; he has been recognized by Who's Who in the World and Limca Book of Records.

Affiliations and Expertise

Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, India

Vasco Azevedo

Vasco Azevedo is graduated from veterinary school of the Federal University of Bahia in 1986. He obtained his Master (1989) and Ph.D. (1993) degrees in microbial genetics from Institut National Agronomique Paris-Grignon (INAPG) and Institut National de la Recherche Agronomique (INRA), France, respectively. He did his Post-doctoral research (1994) at Department of Microbiology, School of Medicine, University of Pennsylvania. USA. Since 1995, he is a Professor at Federal University of Minas Gerais (UFMG), Brazil. In 2004, Prof. Azevedo won the Livre-docência contest at the University of São Paulo, which is considered the best university in Brazil. Livre-docência is a degree awarded by the Higher Education Department of Brazil through a public examination open only to the doctoral degree holders and is a recognition to a superior quality of teaching and research. In 2017, Prof. Azevedo defended his third thesis to become a Doctorate in Bioinformatics from the UFMG. He is a also a Fellow of Brazilian Academy of Sciences. He has published 380 research articles, 3 books, and 29 book chapters. Prof. Azevedo is expert in bacterial genetics, genomics, transcriptome, proteomics, and development of new vaccines and diagnostics against infectious diseases. He is pioneer in genetics of Lactic Acid Bacteria and Corynebacterium pseudotuberculosis in Brazil.

Affiliations and Expertise

Professor, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Brazil

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