Single-Cell Omics

Single-Cell Omics: Volume 1: Technological Advances and Applications provides the latest technological developments and applications of single-cell technologies in the field of biomedicine. In the current era of precision medicine, the single-cell omics technology is highly promising due to its potential in diagnosis, prognosis and therapeutics. Sections in the book cover single-cell omics research and applications, diverse technologies applied in the topic, such as pangenomics, metabolomics, and multi-omics of single cells, data analysis, and several applications of single-cell omics within the biomedical field, for example in cancer, metabolic and neuro diseases, immunology, pharmacogenomics, personalized medicine and reproductive health.

This book is a valuable source for bioinformaticians, molecular diagnostic researchers, clinicians and members of the biomedical field who are interested in understanding more about single-cell omics and its potential for research and diagnosis.

• Covers not only the technological aspects, but also the diverse applications of single cell omics in the biomedical field
• Summarizes the latest progress in single cell omics and discusses potential future developments for research and diagnosis
• Written by experts across the world, bringing different points-of-view and case studies to give a comprehensive overview on the topic

Bioinformaticians, molecular diagnostic researchers, clinicians, geneticists

Section I Overview of Single-Cell Omics
1. Single-Cell Omics: An Overview
2. Recent Progress in Single-Cell Sequencing
3. Cellular Heterogeneity and Single-Cell Omics
4. Single-Cell Omics: Cellular Functions
5. Single-Cell Omics: Deciphering Tumor Clonal Architecture

Section II Omics Technologies in Single-Cell
6. An Overview of Single-Cell Isolation Techniques
7. Microfluidic Techniques for Single-Cell Culture
8. Single-Cell Omics in Noninvasive Diagnosis and Testing—Surface-Enhanced Raman Spectroscopy-Based Approach
9. Single-Cell Genomics: Technology and Applications
10. Single-Cell Metagenomics
11. Single-Cell Epigenomics: Technology and Applications
12. Single-Cell Transcriptomics: Technology and Applications
13. Single-Cell Transcriptomics and Proteomics of Skeletal Muscle: Technology and Applications
14. Single-Cell Proteomics: Technology and Applications
15. Single-Cell Metabolomics: Technology and Applications
16. Single-Cell Phenomics in Budding Yeast: Technologies and Applications
17. Robotics in Single-Cell Omics
18. Single-Cell Editing: The CRISPR/Cas9 and Applications

Section III Data Analysis in Single-Cell Omics
19. Data Analysis in Single-Cell RNA-Seq
20. Systems-Level Understanding of Single-Cell Omics