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Sex and Gender Differences in Alzheimer's Disease - 1st Edition - ISBN: 9780128193440

Sex and Gender Differences in Alzheimer's Disease

1st Edition

Editors: Maria Ferretti Annemarie Dimech Antonella Santuccione
Hardcover ISBN: 9780128193440
Imprint: Academic Press
Published Date: 1st July 2021
Page Count: 301
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Sex and Gender Differences in Alzheimer’s Disease: The Women's Brain Project offers, for the first time, a critical overview of the evidence documenting sex and gender differences in AD neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes and impact on caregivers. This knowledge is crucial for clinical development, digital health solutions, and as social and psychological support to AD families.

Key Features

  • Presents comprehensive and critical reviews of sex differences in Alzheimer’s disease
  • Combines the knowledge and points-of-view of neuroscientists, medical doctors, psychologists and AI experts for a 360 degree view on the topic and its possible implications
  • Edited by the Women’s Brain Project, the leading NGO in the field of sex differences in neuroscience


Neurologists, neuroscientists, psychiatrists, psychologists, nurses, advanced practice practitioners and medical ethicists

Table of Contents

PART 1 Basic Science
1. Sex differences in animal models
2. Sex differences in pathological mechanisms/estrogen response/cellular and system models
3. Sex differences in microglia and abeta clearance
4. Sex differences in brain vascular biology
5. Sex differences in the cholinergic system

PART 2 Clinical science
6. Sex differences in epidemiology
7. Sex differences in neuropsychiatric performance and clinical symptoms
8. Sex differences in CSF biomarkers
9. Sex diff in imaging biomarkers
10. Sex difference in digital biomarkers
11. Sex differences in lifestyle risk factors
12. Sex differences in clinical trials

PART 3 Socio-economic aspects
13. Socioeconomic landscape, risk and costs of AD under the sex and gender lens
14. Women living with Alzheimer: a psychosocial perspective
15. Sex differences in caregiving patterns and caregivers needs
16. Communication and ethical themes in AD – the role of gender
17. How to integrate sex and gender in policy making for AD


No. of pages:
© Academic Press 2021
1st July 2021
Academic Press
Hardcover ISBN:

About the Editors

Maria Ferretti

Dr. Maria Teresa Ferretti is a neuroscientist and neuroimmunologist with expertise in Alzheimer’s disease and gender medicine. After graduating in Chemistry and Pharmaceutical Technologies from the University of Cagliari (Italy), Dr Ferretti started a career as a researcher in the field of neurodegeneration, working in England (for the company Glaxo Smith and Kline), Canada (where she earned a PhD in Pharmacology and Therapy from McGill University of Montreal in 2011) and Switzerland (where she was Group Leader at University of Zurich). She has published numerous scientific papers in prestigious journals including Nature, Science and PNAS; passionate about scientific communication and outreach, she was a TED-x speaker in 2019. Currently, she is the Chief Scientific Officer and co-Founder of the Women’s Brain Project; in addition, she is an external lecturer at the Medical University of Vienna, Austria.

Affiliations and Expertise

Co-founder and Chief Scientific Officer, Women’s Brain Project, Switzerland

Annemarie Dimech

Dr. Annemarie Schumacher Dimech serves as President of the Women’s Brain Project, and is also one of the organization’s co-founders. She heads the new Certificate of Advanced Studies in Palliative Care and the further education programme in Healthcare and Medical Leadership at the University of Lucerne. She graduated in psychology from the University of Malta and further to receiving a Chevening Scholarship, completed an MSc in Health Psychology from the University of Surrey (UK). In 2010, she obtained her PhD at the University of Bern. Today, she is employed at the University of Lucerne where she developed and is heading its programme of further education in Palliative Care and works in the development of further education programmes in healthcare and medicine. Her fascination with the interaction between body and mind motivates her to study physical and environmental factors affecting mental health. Sex and gender differences in various factors, including socioeconomic and psychological factors, affecting brain and mental health was her motivation to join forces with Antonella Santuccione Chadha, Maria Teresa Ferretti, and Gautam Maitra to found the Women’s Brain Project. This approach forms the basis of her work with the Women’s Brain Project, where she contributes to educational and scientific events as well as various projects including publications, research, and other scientific events."

Affiliations and Expertise

Co-founder and President, Women’s Brain Project, Switzerland Program Manager, Palliative Care, University of Lucerne, Lucerne, Switzerland

Antonella Santuccione

Dr. Antonella Santuccione Chadha is a medical doctor with expertise in clinical pathology, neuroscience and psychiatric disorders. She is head of stakeholder engagement for Alzheimer’s disease at Biogen. She is co-founder and CEO of the non-profit organization “Women’s Brain Project” which is addressing the influence of sex and gender on mental and brain diseases. As a medical doctor, Antonella has decades of experience in preclinical research, patient treatment, clinical development, medical affairs and setting up the international regulatory framework for Alzheimer’s disease. Always focused on solving the puzzles related to Alzheimer’s and other psychiatric diseases, she has worked with Swissmedic, the Bill and Melinda Gates Foundation, several European universities, the EU Commission Directorate for Health and Food Safety, the World Health Organization, the CEOi and several Alzheimer’s’ disease Organizations. In 2018 and 2019 she has been nominated among the top 100 Women in Business in Switzerland and in 2019 she has been elected Woman of the Year in Switzerland by the Magazine "Women in Business". In September 2020, she received the World Sustainability Award. She is the Vice-president of Euresearch and act as scientific advisor for several start-up and scientific institutions. Dr. Santuccione Chadha is keenly interested in removing bias when developing solutions for mental and neurological diseases to achieve precision medicines.

Affiliations and Expertise

CEO pro Bono Women’s Brain Project Head of Stakeholder Engagement for Alzheimer’s Disease Biogen International. Vice-President at Euresearch

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