Secure CheckoutPersonal information is secured with SSL technology.
Free ShippingFree global shipping
No minimum order.
Self-organizing Neural Maps: From Retina to Tectum describes the underlying processes that determine how retinal fibers self-organize into an orderly visual map. The formation of neural maps is a fundamental organizing concept in neurodevelopment that can shed light on developmental mechanisms and the functions of genes elsewhere. The book presents a summary of research in the retinotectal field with an ultimate goal of synthesizing how underlying mechanisms in neural development harmoniously come together to create life. A broad spectrum of neuroscientists and biomedical scientists with differing backgrounds and varied expertise will find this book useful.
- Describes the mechanisms relating to the developmental wiring of the retinotectal system
- Brings together the state-of-the-art research in axon guidance and neuronal activity mechanisms in map formation
- Focuses on topographical maps and inclusion of multiple animal models, from fish to mammals
- Explores the molecular guidance and activity dependent cue components involved in neurodevelopment
Graduate students, neuroscientists, neurobiologists, and anyone new to the field of neuroscience; physicians, neurologists, psychologists, computational neuroscientists, bioengineers
Chapter 1: Overview and Basics of the Retinotectal Projection
A. Overview of development of neural circuits.
B. The mature Retinotectal Projection
C. Advantages of studying the Retinotectal System: accessible, easy to manipulate
D. Sperry's early Chemoaffinity theory of map formation
E. Organizational overview of the material
Chapter 2: Early Work Supports, but Also Contradicts, Rigid Chemoaffinity
A. Grafted eyes regenerate optic nerves to restore vision
B. Optic Nerve Regeneration restores original connections even when maladaptive
C. Behavioral evidence of the retinotectal map and its faithful regeneration
D. Regeneration with single axis reversals
E. Embryonic Eye Rotations and the onset of polarization in development
F. Electrophysiological mapping demonstrates regeneration of the map
G. Anatomical mapping of the retinotectal projection
H. "Compound” eyes demonstrate the inadequacy of rigid chemoaffinity
I. Qualitative Models of Map Formation
Chapter 3: The search for chemoaffinity molecules—verification of molecular gradients
A. Using monoclonal antibodies to search for chemoaffinity molecules
B. Culture assays of retinal fiber preferences in tectum
C. The genetic approach defines Eph receptors and ephrin ligand families
D. Eph and ephrin family members and revised nomenclature
E. Simple model of how gradients can determine the RT map
Chapter 4: Plasticity after surgical ablations shows the limits of chemoaffinity
A. Size disparity: Compression of the whole projection onto a half tectum
B. Size disparity: half retinal projections expand across tectum
C. Size disparity: induced binocular projections to one tectal lobe
D. “Compound” eyes projections revisited
E. Embryonic retinal ablations: further complications.
F. Proposed quantitative computer models and what they can explain
G. Summary of plasticity of retinotectal projections
Chapter 5: Natural Plasticity--Analysis of the effects of divergent retinal and tectal growth on the projection.
A. Early morphogenesis of retina and tectum differ in their geometries
B. Histogenesis of retina—cells added in an annulus around the edge
C. Visual consequences of continued retinal growth
D. Histogenesis of tectum and its control—cells added in crescent open on one end.
E. The shifting connections hypothesis
Chapter 6: Specification and developmental genetics of Eph/ephrin gradients
A. The developmental origins of retinal specification and expression of Eph/ephrin gradients
B. The developmental origins of tectal specification
Chapter 7: Growth of retinal axons along the visual pathway
A. Morphogenesis of Optic Cup and Optic Stalk during development
B. Axonal outgrowth: pathfinding within retina
C. Growth and order of axons in the optic nerve and tract
D. The Ipsilateral RT projection from the ventrotemporal (VT) retinal axons in mammals
E. How the initial projection to the tectum forms
F. Implications for Theoretical Models
Chapter 8: Genetic Analysis of the molecular gradients defining map formation
A. AP axis: The gradients of EphA receptors in retina and of ephrinA ligands in tectum
B. DV axis: gradients of EphB & ephrinB in retina & tectum; plus other mechanisms
Chapter 9: Activity mechanisms shape central retinal projections
A. Early studies on nicotinic receptors, α-Bungarotoxin, modulation and synapse stabilization
B. Activity-dependent map sharpening via NMDA receptors
C. The role of activity in sensory map alignments—several cases with the same theme
D. Role of activity in eye specific segregation
Chapter 10 Activity: Molecular signaling to growth mechanisms
A. Dynamic analysis of arbor growth-- NMDAR-mediated effects on structure
B. Plasticity mechanisms linked to Long Term Potentiation and LT Depression (LTP & LTD)
C. Cam Kinase II and growth control in Xenopus tectum
D. LTP and LTD are coupled to BDNF and NO retrograde signaling in Xenopus
E. LTP and LTD in mammalian tectum
F. LTD is associated with NO signal and branch retraction in rodent tectum.
G. LTP and BDNF effects in rodent and frog tectum
H. F-actin based mechanisms control growth of new branches
I. Summary of growth control mechanisms
Summary Chapter: Synopsis of Mechanisms Generating the Retinotectal Map
B. Little or no contributions from 3 mechanisms
C. Three main mechanisms contribute to map formation
D. Basic differences arise between anamniotes (fish/frog) and amniotes (chick/mammals)
E. Rules apply to other visual, nonvisual structures
F. These rules apply to the development of other visual and nonvisual projections
G. Successful models incorporate both fiber-target and fiber-fiber gradients as well as activity
- No. of pages:
- © Academic Press 2020
- 15th October 2019
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Dr. Schmidt is Professor Emeritus at the University of Albany (SUNY) in the Department of Biological Sciences. He has worked in the retinotectal area since the early 1970s and published more than 60 articles and chapters. For the last four decades, he was Professor of Biological Sciences at SUNY-Albany, serving for 25 years as the Director of the Center for Neuroscience Research. In the 1990s, he together with Professor Jonathan Wolpaw organized an international conference on the wider subject and edited a volume of the proceedings for the Annals of the New York Academy of Sciences, entitled Activity-Driven CNS Changes in Learning and Development (Volume 627). This volume was the NY Academy’s bestselling issue of all time.
Professor Emeritus, Department of Biological Sciences, University of Albany
Elsevier.com visitor survey
We are always looking for ways to improve customer experience on Elsevier.com.
We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit.
If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website.
Thanks in advance for your time.