Self-assembling Biomaterials

Self-assembling Biomaterials

Molecular Design, Characterization and Application in Biology and Medicine

1st Edition - April 17, 2018

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  • Editors: Helena S. Azevedo, Riccardo M. P. da Silva
  • eBook ISBN: 9780081020128
  • Hardcover ISBN: 9780081020159

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Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community.

Key Features

  • Explores both theoretical and practical aspects of self-assembly in biomaterials
  • Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials
  • Examines the use of dynamic self-assembling biomaterials


Materials scientists, biomedical engineers, chemists working in the field of soft-matter, biomaterials and stem cells for tissue engineering

Table of Contents

  • 1. Self-assembling biomaterials: beginnings and progress over the past decade

    Part 1 Molecular building blocks for self-assembly
    2. Designing peptides for self-assembling biomaterials with controlled mechanical and biological performance
    3. Engineering silk fibroin for hydrogel self-assembly
    4. Elastin-like proteins – modular design for self-assembly
    5. Sweet building blocks for self-assembling biomaterials with molecular recognition
    6. Peptoid self-assembly and opportunities for biomaterials and biointerfaces
    7. Lipid bolaamphiphiles for fabricating membrane-mimetic biomaterials
    8. Self-assembling protein-DNA hybrid molecules as building blocks for complex biomaterials
    9. Biomaterials based on ureido-pyrimidinone (UPy) and benzene-1,3,5-tricarboxamide (BTAs) supramolecular polymers
    10. Self-assembling of biomaterials using host-guest chemistry

    Part 2 Unique properties of self-assembling biomaterials: blurring the frontiers between biomaterials and biology
    11. Adaptive supramolecular biomaterials through non-equilibrium self-assembly

    Part 3 Nanoscale characterization of self-assembling biomaterials
    12. Unveiling complex structure and dynamics in supramolecular biomaterials using super-resolution microscopy
    13. Probing local molecular dynamics in self-assembling systems with electron paramagnetic resonance (EPR) spectroscopy
    14. Small angle X-ray scattering (SAXS) to study spatial arrangement in self-assembled biomaterials
    15. Studying nanoscale interactions in self-assembling systems through molecular simulations

    Part 4 Mechanisms of self-assembly: controlling driving forces and boundaries for self-assembly across scales
    16. Magnetic fields to align peptide assemblies and provide directionality in biomaterials
    17. Using confined environments to control the shape and size of assemblies
    18. Engineering dynamic self-assembling biomaterials at the interface
    19. Enzymatic mediated self-assembly

    Part 5 Applications of self-assembling biomaterials
    20. Recreating stem cell niches using self-assembling biomaterials
    21. Bioactive self-assembling scaffolds for regenerative medicine
    22. Functionalization of self-assembling peptides for neural tissue engineering
    23. Self-assembling biomaterials as nanocarriers for the targeted delivery of drugs for cancer
    24. Self-assembling biomaterials for theranostic applications
    25. Self-assembling artificial enzymes: biomaterial therapies for metabolic diseases

Product details

  • No. of pages: 612
  • Language: English
  • Copyright: © Woodhead Publishing 2018
  • Published: April 17, 2018
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780081020128
  • Hardcover ISBN: 9780081020159

About the Editors

Helena S. Azevedo

Dr Helena S. Azevedo is a senior Lecturer in Biomedical Engineering and Biomaterials at Queen Mary University of London, UK. She has more than 15 years of research experience in biomaterials engineering and has developed significant work on the development of self-assembling biomaterials for biomedical applications.

Affiliations and Expertise

Senior Lecturer in Biomedical Engineering and Biomaterials and Director of Operations, Institute of Bioengineering, Queen Mary University of London, UK

Riccardo M. P. da Silva

Dr. Ricardo da Silva has 13 years of research experience in the field of Biomaterials for Regenerative Medicine applications. His research work covers thermo-responsive polymers for drug delivery and cell sheet engineering, peptide self-assembly and supramolecular chemistry. He is a Research fellow at King’s College London, at the Centre for Craniofacial and Regenerative Biology, where he develops his research activities in self-assembling biomaterials and bone tissue engineering.

Affiliations and Expertise

Centre for Craniofacial and Regenerative Biology, Dental Institute, King’s College London, UK

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