Table of Contents




List of Contributors

List of Contributors

Volume 1

I: Epithelial and Nonepithelial Transport and Regulation

Chapter 1. Epithelial Cell Structure and Polarity


Epithelial Cell Structure: Morphology and Physiology

Biogenesis of Epithelial Polarity



Chapter 2. Mechanisms of Ion Transport across Cell Membranes


Mechanisms of ion TRANSPORT

Ion Transport PROTEINS


Chapter 3. Renal Ion-Translocating ATPases


Structure and Function of Ca2+-ATPases (SERCA and PMCA)

Structure of Na,K-ATPase and H,K-ATPase

Properties of Na,K-ATPase and H,K-ATPase

Regulation of Na,K-ATPase

New Physiological Functions of Na,k-ATPase

Na,K-ATPase in the Kidney

H,K-ATPases in Kidney

Structure and Mechanism of Action of V-ATPases


Chapter 4. Mechanisms of Water Transport Across Cell Membranes and Epithelia


Basic Principles

Water Transport Across the Cell Membrane

Water Transport in Epithelia


Chapter 5. Cell Volume Control

Cell Volume Regulatory Mechanisms

Challenges and Functions Affecting Cell Volume


Chapter 6. Solute Transport, Energy Consumption, and Production in the Kidney


Energy Consumption

Metabolic Basis in the Kidney

Coupling of Transport and Metabolism in the Kidney


Pathophysiological States in Energy Production in the Kidney



Chapter 7. Electrophysiological Analysis of Transepithelial Transport


Transepithelial Measurements


Intracellular Measurements



No. of pages:
© 2013
Academic Press
Not Applicable ISBN:
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About the authors

Robert Alpern

Dr. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in Internal Medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the medical school. He is now Dean of Yale School of Medicine and Ensign Professor.

Affiliations and Expertise

Dean and Ensign Professor of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

Michael Caplan

Dr. Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in Autosomal Dominant Polycystic Kidney Disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. Following postdoctoral work in the Department of Cellular and Molecular Physiology at Yale, Caplan joined that department as a faculty member. He is currently the C.N.H. Long Professor and Chair of Yale University School of Medicine’s Department of Cellular and Molecular Physiology.

Affiliations and Expertise

C.N.H. Long Professor and Chair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA

Orson Moe

Dr. Moe received his medical degree from the University of Toronto where he also did his internal medicine residency and clinical nephrology fellowship. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and is a member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Orson Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology.

Affiliations and Expertise

Professor of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA