Scientific and Engineering Principles - 1st Edition - ISBN: 9780080253831, 9781483148458

Scientific and Engineering Principles

1st Edition

Proceedings of the Sixth International Fermentation Symposium Held in London, Canada, July 20-25, 1980

Editors: Murray Moo-Young Campbell W. Robinson Claude Vezina
eBook ISBN: 9781483148458
Imprint: Pergamon
Published Date: 1st January 1981
Page Count: 808
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Advances in Biotechnology, Volume I: Scientific and Engineering Principles is the first of a series of three volumes and is based on the proceedings of the Sixth International Fermentation Symposium (IFS-6) held in London, Ontario, Canada, 20-25 July 1980. This volume is organized into 13 sections and contains 111 papers which represent about 80% of the total submitted. Section I contains papers on microbial cultures. Section II presents studies on recombinant DNA and microbial genetics. The papers in Section III deal with plant and animal cell and tissue culture. Section IV examines the microbial oxidation of hydrocarbons. Sections V and VI focus on continuous cultures and free-cell fermentation, respectively. Section VII examines process dynamics and control. Section VIII takes up computer applications in biotechnology, while Section IX covers process instrumentation and analytical methods. Section X contains papers on transport phenomena, mixing and scale-up. Section XI examines the design and operation of unconventional bioreactors. Sections XII covers fixed-, fluidized- and semi-fluidized bed bioreactors, while Section XIII presents studies on immobilization bioreactors. The volume also includes invited keynote addresses of Nobel Laureate, Professor Joshua Lederberg, and Professor Elmer L. Gaden, Jr. Abstracts of the round-table discussion on Technology Transfer and Economics, and on Biotechnology Training Programs are presented as appendices.

Table of Contents


Guest Editorial I. Biochemical Engineering: Where Has it Been and Where is it Going?

Guest Editorial II. Genetics and Industrial Microbiology: Still Further Horizons

Section I. Microbial Cultures: Screening, Improvement, Patents

1. Strain Improvement Programs in Antibiotic-Producing Microorganisms - Present and Future Strategies

2. New Organisms of Economic Importance: the Case of Frankia

3. Mixed Cultures in Industrial Processes

4. Cultures and Patents

5. Production of Pharmacologically Active Agents from Microbial Origin

6. Screening of Basidiomycetes for the Production of New Antibiotics

7. Screening of Bacterial Isolates for Antigonococcal Activities

8. Isolation of Carboxyl Proteinases of Microbial Origin on Pepstatinsepharose Resin

9. Rapid Strain Selection for Citric Acid Production

10. Use of Cerulenin in Selecting Improved Mutants of Daunorubicin-Producing Streptomycete

11. Improvement of the Daunorubicin Fermentation Realized at 10,000 Liter Fermentor Scale

12. Studies on the Avermectin Fermentation

13. The Influence of Oxygen Concentration on Microbial Insecticide Production

Section II. Recombinant DNA and Microbial Genetics

14. Enzymatic Hydrolysis of some Penicillins and Cephalosporins by Cloned Escherichia coli Acylase

15. Expansion of the Host Range of Pl and Mu Phages and Gene Transfer between Intergeneric Bacteria

16. Stability of trp Operon Recombinant Plasmid in E. coli

17. Genetic Control of Dikaryotic Fruiting in the Basidiomycete

Section III. Cell and Tissue Culture - Plant and Animal

18. Advances in Plant Cell Culture towards Improved Yields of Secondary Products (Alkaloids)

19. Aspects on Scale-up and Mass Cultivation of Plant Tissue Culture

20. Present and Future Trends in Plant Tissue Culture

21. Effects of Media Constituents on the Formation of Secondary Products in Cell Suspension Cultures of Catharanthus roseus

22. Hormonal Regulation of Scopoletin and Scopolin Productions in Tobacco Tissue Culture

23. Engineering Characterization of Animal Cell and Virus Production Using Controlled Charge Microcarriers

Section IV. Microbial Oxidation of Hydrocarbons

24. Uptake and Oxidation of Hydrocarbons by a Mutant Derived from Itaconate-Producing Yeast

25. Study of Hydroxylase and its Components in Candida tropioalis Grown on Alkane

26. Plasmid Involvement in Bacterial Degradation of Phenanthrene

27. Induction of Enzymes for n-Alkane Degradation in Two Strains of Pseudomonas aeruginosa

28. Structural Changes of the TOL Plasmid pWWO

29. Utilization of n-Alkanes by Microorganisms: Biological Aspects of Transport

Section V. Continuous Cultures

30. The Utility of Chemostat Cultures in Studies of Microbial Physiology

31. Continuous Culture: Some Contemporary Problems from Another Viewpoint

32. Nutrient Control of Growth at the Cellular Level: Some Studies Conducted with Candida utilis in Continuous Phased Culture

33. Continuous Culture: Its Influence on Engineering Practice

34. The Enzyme Activity as Growth Rate Limiting Step in a Chemostat

35. Selection of Escherichia coli with Increased Endoenzyme Synthesis in Continuous Culture

36. Continuous Process for Production of Citric Acid

37. Kinetics of Virus Replication and Glucoamylase Biosynthesis in Aspergillus niger Repeated Fed-Batch Culture

38. Auto-Selection of Very Rapidly Growing Microorganisms

39. Gel-Forming Exopolysaccharide Production by Alcaligenes faecalis Grown in Nitrogen-Limited Continuous Culture

40. New Developments in the Elucidation of the Mechanisms of the Pasteur and Crabtree Effects in Bacteria

41. The Crabtree Effect in Saccharomyces cerevisiae: Primary Control Mechanism or Transient?

42. Regulatory Aspects in Yeast Metabolism

43. Growth of Hansenula polymorpha on Mixed Substrates and Regulation of Alcohol Oxidase Synthesis

44. A Quantitative Description of the Growth of Saccharomyces cerevisiae CBS 426 in Continuous Cultures on a Mixture of Two Carbon Sources

45. Cellular Yields and Maintenance Requirements of Alcaligenes eutrophus during Hydrogen Oxidation

46. Light Supply and Quantum Efficiencies in a Model Reactor for Continuous Phototrophic Growth

47. Properties of the Green Alga Chlorgonium elongatum during Light-Limited Continuous Culture in the Phauxostat

Section VI. Free-Cell Fermentation: Modeling, Simulation and Process Development

48. Optimal Conditions for Production of Cephalosporin C in Fed-Batch Culture

49. Kinetics of Substrate Utilization in Repeated Fed-Batch Culture and Fitting Computer Simulation Data to Experimental Data of Antibiotic Biosynthesis

50. A Model for the Growth and Product Kinetics of Facultative Anaerobes Based on ATP Synthesis and Consumption

51. An Unstructured Model of Algal Growth in Continuous Culture

52. The Development of a Semi-Solid Fermentation System for the Production of Lysine-Enriched Yeast and Ethanol

53. Effect of Oxygen on Amino Acids Fermentation

54. The Influence of Low Dissolved Oxygen Levels in Fermentors on Ethanol Production by Candida tropicalis

55. Effect of Water Activity on Microbial Growth

56. Death Rates of Bacterial Spores at High Temperature in a Continuous Stirred Tank Reactor

Section VII. Process Dynamics and Control

57. Analysis of Basic Principles of Fermentation Process Control

58. Production of Cellulase in Fed-Batch Culture

59. Dynamics and Control of a Biological Phenol Wastewater Treatment Reactor

60. The Redox Potential, a Hitherto Seldom Used Parameter in Fermentation Systems

61. Determination of Kinetic Process Parameters by Dynamic Methods Taking into Account the Inertia of Measuring Instrument

62. Application of Experimental Methods to Identify Process Dynamics of Fermentation Processes

Section VIII. Computer Applications in Biotechnology

63. Direct Monitoring of a Fermentation in a Computer-Mass Spectrometer-Fermemtor Systems

64. State Estimation for Computer Control of Biochemical Reactors

65. An Approach to On-Line Optimization of Biomass Production in Continuous Processes

66. Automatic Control of Dissolved Oxygen Concentration with Microcomputer

67. Ethanol- and Ro-Based Computer Control in Fed Batch Culture of Baker's Yeast

68. Progress with Computer-Coupled Mammalian Cell Culture Investigations

Section IX. Process Instrumentation and Analytical Methods

69. A New Sensor, the "Filtration Probe", to Monitor and Control Antibiotic Fermentations

70. A Porous Membrane-Carrier Gas Measurement System for Dissolved Gases and volatiles in Fermentation Systems

71. Fermentor Monitoring and Control by Enzyme Thermistors

72. Measurement of the Solubility of Oxygen during Fermentations

73. Determination of Adenosine Nucleotides with Luciferin/Luciferase from Crude Firefly Lantern Extract on a Bioluminescence Analyzer

Section X. Transport Phenomena, Mixing and Scale-up

74. Physical Transport Phenomena in Bubble Column Bioreactors - I: Gas-liquid Mass Transfer

75. Physical Transport Phenomena in Bubble Column Bioreactors - II: Liquid-solid Mass Transfer, Mixing and Heat Transfer

76. The Two-Zone Model: A Quantitative Description of the Oxygen Mass Transfer in Bubble Columns and Three-Phase Fluidized Beds

77. Turbine Agitated Gas Dispersion: Power, Flooding and Hold-up

78. Bubble Coalescence and Break-up in Fermentations

79. Gas Liquid Contacting in Highly Viscous Liquids

80. Power and Hold-up in the Mixing of Aerated Highly Viscous Non-Newtonian Fluids

81. Gas Absorption with Simultaneous Biochemical Reaction

82. Some Scale-up Considerations for Fermentation Mixers

83. Circulation times of Various Fluids in Stirred Fermentors

84. Modeling and Scale-up of Anaerobic Conversion of Dissolved Fatty Acids

Section XI. Unconventional Bioreactors: Design and Operating Characteristics

85. High Productivity Anaerobic Fermentation with Dense Cell Culture

86. Mass Transfer and Liquid Mixing in External-Circulation-Loop Contactors

87. Gas-Liquid Dispersion Characteristics in Airlift Fermentors

88. Liquid Velocity as an Important Design Parameter for Airlift Loop-Fermentors

89. Single and Multi-Stage Countercurrent Bubble Column Loop Reactor Performance

90. Penicillin Production in a Bubble Column Airlift Loop Reactor

91. Oxygen Transfer and Biological Effects in a Deep-Tank Aeration System

92. Effectiveness of Energy Introduced into Fermentors

93. Novel Reactor Configuration for Small-Scale Microbiological Leaching

94. On-Line Extraction Fermentation Processes

95. Modification of Non-Newtonian Mycelial Fermentation Broth through Confinement of Growth Using Microscopic Beads

Section XII. Fixed-, Fluidized- and Semi-Fluidized Bed Bioreactors

96. Optimum Operation Policy for a Fixed and Moving Bed Reactor with Deactivating Enzyme Catalyst: Optimum Temperature and Optimal Temperature Profile

97. Ethanol Fermentation in a Yeast Immobilized Column Fermentor

98. Fluidization Principles and Applications to Biotechnology

99. Oxygen Transfer in Three Phase Fluidized Beds

100. Tapered Fluidized Bed Bioreactors for Environmental Control and Fuel Production

101. Fluidized Bed Reactor for the Production of Methane from Sugar Cane Bagasse

102. Semifluidized Bed Bioreactor

Section XIII. Immobilization Bioreactors

103. Optimal Operation and Replacement Policies for Decaying Immobilized Enzyme

104. Dextran Production by Free and Immobilized Dextransucrase

105. Immobilized ß-Glucanase in Brewing

106. The Effects of Solvents on the Hydrolysis of Lipids by Free and Immobilized Microbial Lipase

107. Immobilization of a Penicillium duponti Proteolytic Enzyme and its Application in Solubilization of Soybean Protein in a Spiral-Wound Recycle Reactor

108. Glucoamylase Hollow Fiber Reactors

109. Immobilized Live Cells

110. Magnetic Immobilized Microorganisms

111. Macromolecular NAD+-derivative of High Coenzyme Activity and its Application for a Model Reaction


Appendix IA. Overview of Technology Transfer and Economics I

Appendix IB. Overview of Technology Transfer and Economics II

Appendix II. Overview of Training Programs in Biotechnology and Biochemical Engineering

Contents of Other Volumes

Volume II. Fuels, Chemicals, Foods and Waste Treatment

Volume III. Fermentation Products

Contents of "Current Developments in Yeast Research" (ISY-5)

Author Index

Subject Index


No. of pages:
© Pergamon 1981
eBook ISBN:

About the Editor

Murray Moo-Young

Affiliations and Expertise

University of Waterloo, Canada

Campbell W. Robinson

Claude Vezina

Ratings and Reviews