Science and Principles of Biodegradable and Bioresorbable Medical Polymers - 1st Edition - ISBN: 9780081003725, 9780081003930

Science and Principles of Biodegradable and Bioresorbable Medical Polymers

1st Edition

Materials and Properties

Editors: Xiang Zhang
eBook ISBN: 9780081003930
Hardcover ISBN: 9780081003725
Imprint: Woodhead Publishing
Published Date: 4th October 2016
Page Count: 476
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Description

Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties provides a practical guide to the use of biodegradable and bioresorbable polymers for study, research, and applications within medicine. Fundamentals of the basic principles and science behind the use of biodegradable polymers in advanced research and in medical and pharmaceutical applications are presented, as are important new concepts and principles covering materials, properties, and computer modeling, providing the reader with useful tools that will aid their own research, product design, and development.

Supported by practical application examples, the scope and contents of the book provide researchers with an important reference and knowledge-based educational and training aid on the basics and fundamentals of these important medical polymers.

Key Features

  • Provides a practical guide to the fundamentals, synthesis, and processing of bioresorbable polymers in medicine
  • Contains comprehensive coverage of material properties, including unique insights into modeling degradation
  • Written by an eclectic mix of international authors with experience in academia and industry

Readership

Materials scientists, chemists, biologists, engineers, and R&D managers as well as undergraduates, postgraduates and other academics

Table of Contents

  • Related titles
  • List of contributors
  • Woodhead Publishing Series in Biomaterials
  • 1. Biodegradable medical polymers: Fundamental sciences
    • 1.1. Introduction
    • 1.2. Biodegradable polymer chain structures
    • 1.3. Physical properties of biodegradable polymers
    • 1.4. Biodegradable polymers in solid state
    • 1.5. Biodegradable polymers in solutions
    • 1.6. Biodegradable polymer hybrids
    • 1.7. Materials selection and design control for medical applications
    • 1.8. Summary – key points learnt in the chapter
  • Part One. Biodegradable and bioresorbable syntheticmedical polymers
    • 2. Synthetic biodegradable medical polyesters
      • 2.1. Introduction
      • 2.2. Synthesis methods and structure-properties
      • 2.3. Physico-chemical properties
      • 2.4. Degradation of poly(lactic acid) and poly(glycolic acid) polymers
      • 2.5. Case studies for biomedical and pharmaceutical applications
      • 2.6. Future trends
    • 3. Synthetic biodegradable medical polyesters: Poly-ε-caprolactone
      • 3.1. Introduction
      • 3.2. Chemical structure and methods for producing poly-ε-caprolactone
      • 3.3. Processing techniques of poly-ε-caprolactone
      • 3.4. Mechanical properties and degradation of poly-ε-caprolactone-based biomaterials
      • 3.5. Surface functionalisation of poly-ε-caprolactone and poly-ε-caprolactone biological properties
      • 3.6. Case studies of medical applications
      • 3.7. Commercialisation and future trends of poly-ε-caprolactone-based biomaterials
      • 3.8. Summary – key points learnt in the chapter
    • 4. Synthetic biodegradable medical polyesters: Poly(trimethylene carbonate)
      • 4.1. Introduction
      • 4.2. Synthesis and structure–properties
      • 4.3. Degradation of poly(trimethylene carbonate) and copolymers
      • 4.4. Biomedical and pharmaceutical applications
      • 4.5. Conclusion and perspectives
    • 5. Synthetic biodegradable medical polymer: Polyanhydrides
      • 5.1. Introduction
      • 5.2. Historical perspective
      • 5.3. Classification of polyanhydrides and chemical structures
      • 5.4. Methods of synthesis
      • 5.5. Processing techniques
      • 5.6. Degradation mechanism
      • 5.7. Biocompatibility
      • 5.8. Medical applications of polyanhydrides
      • 5.9. Future trends
      • 5.10. Summary
      • List of abbreviations
    • 6. Synthetic biodegradable medical polyurethanes
      • 6.1. Introduction
      • 6.2. Synthesis methods of polyurethanes
      • 6.3. Degradable and biocompatibile polyurethanes: selection of block constituents
      • 6.4. Main general applications of degradable polyurethanes in regenerative medicine and drug release
      • 6.5. Future trends
      • 6.6. Summary – key points learnt in the chapter
    • 7. Synthetic biodegradable medical polymers: Polymer blends
      • 7.1. Introduction
      • 7.2. Thermodynamics and nanophase diagram of biodegradable polymer blends
      • 7.3. Biodegradable polymer blends
      • 7.4. Case studies of medical applications
      • 7.5. Future trends
      • 7.6. Summary – key points learnt in the chapter
  • Part Two. Biodegradable and bioresorbable naturalmedical polymers
    • 8. Natural bacterial biodegradable medical polymers: Polyhydroxyalkanoates
      • 8.1. Introduction
      • 8.2. Types of polyhydroxyalkanoates and their properties
      • 8.3. Degradation of polyhydroxyalkanoates
      • 8.4. Applications of polyhydroxyalkanoates
      • 8.5. Future trends
      • 8.6. Summary – key points learnt in the chapter
    • 9. Natural biodegradable medical polymers: Cellulose
      • 9.1. Introduction
      • 9.2. Types and chemical structure of cellulose
      • 9.3. Degradation mechanisms
      • 9.4. Processing techniques
      • 9.5. Case studies: cellulose application in medical applications
      • 9.6. Future trends
      • 9.7. Summary – key points learnt in the chapter
    • 10. Natural bacterial biodegradable medical polymers: Bacterial cellulose
      • 10.1. Introduction
      • 10.2. Types and chemical structure of bacterial cellulose
      • 10.3. Processing techniques
      • 10.4. Case studies of medical applications
      • 10.5. Future trends
      • 10.6. Summary – key points learnt in the chapter
    • 11. Natural biodegradable medical polymers: Therapeutic peptides and proteins
      • 11.1. Introduction
      • 11.2. Structure and bioactive properties of food proteins/peptides
      • 11.3. Instability of proteins/peptides
      • 11.4. Oral delivery of proteins/peptides
      • 11.5. Medical applications of nisin, a food preservation additive
      • 11.6. Future trends
      • 11.7. Summary – key points learnt in the chapter
    • 12. Natural biodegradable medical polymers: Silk
      • 12.1. Introduction
      • 12.2. Types and chemical structure of silk
      • 12.3. Processing techniques of silk
      • 12.4. Mechanical properties
      • 12.5. Degradation mechanisms
      • 12.6. Medical applications
      • 12.7. Future trends
      • 12.8. Summary – key points learnt in the chapter
  • Part Three. Properties of biodegradable medical polymers
    • 13. Biocompatibility of biodegradable medical polymers
      • 13.1. Introduction: definitions of biocompatibility
      • 13.2. Chemical compatibility
      • 13.3. Mechanical compatibility
      • 13.4. Interactions between degradable polymers and biological systems
      • 13.5. Design principles to ensure biocompatibility for medical applications
      • 13.6. Summary – key points learnt in the chapter
    • 14. Degradation characterisation of biodegradable polymers
      • 14.1. Introduction
      • 14.2. In vitro characterisation of degradation studies
      • 14.3. Effect of isotope on degradation rate
      • 14.4. New imaging technology for degradation studies
      • 14.5. Mechanical characterisation
      • 14.6. Summary – key points learnt in the chapter
    • 15. Modelling degradation of biodegradable polymers
      • 15.1. Introduction
      • 15.2. Diffusion kinetics – Fick's law and water diffusion modelling
      • 15.3. Computer modelling of polymer degradation
      • 15.4. Computer modelling of the mechanical property change during biodegradation
      • 15.5. Summary – key points learnt in this chapter
  • Index

Details

No. of pages:
476
Language:
English
Copyright:
© Woodhead Publishing 2017
Published:
Imprint:
Woodhead Publishing
eBook ISBN:
9780081003930
Hardcover ISBN:
9780081003725

About the Editor

Xiang Zhang

Dr. Zhang has the benefit of academic and industrial experience in the medical industry, having worked in academia for 17 years before moving to applied research for industry in 1999. For the last 15 years, he has been involved in fundamental, applied research (mainly for industry) in polymers and his fundamental understanding of polymer science has helped him to develop successful medical products. Dr. Zhang’s work has covered most aspects of medical materials and medical devices from R&D stages to manufacturing. In addition to working as Principal Consultant for Lucideon, Dr. Zhang is currently organizing and supervising research in degradable polymers and their hybrid composites for medical applications at the University of Cambridge.

Affiliations and Expertise

Royal Society Industry Fellow, University of Cambridge, UK; Principal Consultant, Lucideon, UK