Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

5th Edition

Print ISBN: 9780124105294
eBook ISBN: 9780124105492
Imprint: Academic Press
Published Date: 13th November 2014
Page Count: 1464
195.00 + applicable tax
155.00 + applicable tax
250.00 + applicable tax
Compatible Not compatible
VitalSource PC, Mac, iPhone & iPad Amazon Kindle eReader
ePub & PDF Apple & PC desktop. Mobile devices (Apple & Android) Amazon Kindle eReader
Mobi Amazon Kindle eReader Anything else

Institutional Access


Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format.

Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases.

Key Features

  • Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease
  • Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain
  • Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations


Clinical neurologists, psychiatrists, psychologists, neuroscience researchers, clinical neurology researchers, general medical practitioners, and genetic and molecular biologists with an interest in neurogenetics

Table of Contents

Introduction to the 5th Edition
  Roger N. Rosenberg and Juan M. Pascual

1. Mendelian, nonmendelian, multigenic inheritance and epigenetics
  Tamar Harel, Davut Pehlivan, C. Thomas Caskey and James Lupski
2. Genotype-phenotype correlations
  Thomas D. Bird and Marie Davis
3. Immunogenetics of neurological disease
  Ramyiadarsini I. Elangovan, Sreeram V. Ramagopalan and David A. Dyment
4. Pharmacogenomic Approaches to the Treatment of  Sporadic Alzheimer's Disease using Cholinomimetic Agents
  Judes Poirier, Justin Miron and Cynthia Picard
5. Application of Mouse Genetics to Human Disease: Generation and Analysis of Mouse Models
  Teresa M. Gunn and Brenda Canine
6. DNA sequencing and other methods of exonic and genomic analysis
  Jin Mitsui, Hiroyuki Ishiura and Shoji Tsuji
7. Association, cause and  causal association: means, methods and measures
  Walter Anthony Kukull
8. Gene Therapy for Neurological Disease
  Theodore Friedmann
9. Direct induction of neural stem cells from somatic cells
  Hideyuki Okano
10. Neuroimaging in Dementias
  Prashanthi Vemuri, Melissa E. Murray and Clifford R. Jack
11. Cognitive Enhancers and Mental Impairment:  Emerging Ethical Issues
  Fabrice Jotterand, Jennifer McCurdy and Bernice Elger
12. Genetic counseling
  Wendy R. Uhlmann

13. Cerebral Malformations
  William David Graf and Shihui Yu
14. Global Developmental Delay and Intellectual Disability
  Michael Shevell and Myriam Srour
15. Down syndrome
  Allison M. Caban-Holt, Elizabeth Head and Frederick Schmitt
16. An Overview of Rett Syndrome
  Kristen L. Szabla and Lisa M. Monteggia
17. Fragile X-associated Disorders
  Reymundo Lozano, Em


No. of pages:
© Academic Press 2015
Academic Press
eBook ISBN:
Hardcover ISBN:


"...a thoroughly updated, essential book on the genetics of neurological and psychiatric disorders. Every clinician and researcher in neurology and psychiatry ought to be aware of the important information contained in this outstanding book. Score: 91 - 4 Stars" --Doody's

"Genetics and genomics have changed the practice of neurology and will continue to have huge impact on every discipline of medicine. In this fifth edition of the "bible" of Neurogenetics, Dr. Rosenberg and Dr. Pascual have done a remarkable job in leading the assembly of a volume that is truly representative of this rapidly advancing field –more than ½ of the chapters are new since the last edition. Here, in one place, one can access not only the genetics of common disorders, but virtually every metabolic disorder seen by neurologists, and new chapters on some of the major psychiatric disorders where genetics has played a crucial role in beginning to clarify disease pathophysiology. All of the major disorders, from those afflicting cortex to peripheral muscle are covered by the leading experts in their fields in a clear and authoritative manner. The organization is well conceived and progressive, beginning by providing a conceptual basis for the field, covering basic topics such as genetic counseling, genotype-phenotype relationships, the determination of causality in genetics, and new technologies such as genome sequencing in an exceptionally clear and comprehensive manner. Whether an expert or novice, if you are looking for one book that covers the field from A to Z, this is it." --Daniel Geschwind, Gordon and Virginia MacDonald Distinguished Professor Neurology, Psychiatry and Human Genetics and Director, Center for Autism Research and Treatment, Semel Institute, University of California, Los Angeles, CA