Description

Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, and RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation.

Key Features

* Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway * Expert researchers introduce the most advanced technologies and techniques * Offers step-by-step lab instructions, including necessary equipment and reagents

Readership

Biochemists and researchers in related life science disciplines.

Details

No. of pages:
464
Language:
English
Copyright:
© 2008
Published:
Imprint:
Academic Press
Print ISBN:
9780123745842
Electronic ISBN:
9780080923321

About the editors

Lynne E. Maquat

Affiliations and Expertise

University of Rochester, NY, USA

Megerditch Kiledjian

Affiliations and Expertise

Rutgers University, New Brunswick, NJ, USA