Reproductive Immunology

Reproductive Immunology

Basic Concepts

First published on February 12, 2021

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  • Editor: Gil Mor
  • Paperback ISBN: 9780128185087
  • eBook ISBN: 9780128189306

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Reproductive Immunology: Basic Concepts gives a holistic insight into the understanding of the complex interactions between the maternal immune system and the fetal/placental unit necessary for the success of pregnancy. This interaction is critical for the support of the human fetal semiallograft and the protection against infections. The book covers various topics such as B cells, macrophages, T cells, discussion on fetal signals and their impact on maternal reproductive cells such as endometrial cells, mast cells, and the role of fetal Hofbauer cells, the immune regulatory role of glucorticoids, and many other novel topics within the field of reproductive immunology. Edited and written by experts in the field, this book introduces the up-to-date knowledge of the role of the immune system during pregnancy and provides the necessary background to understand pregnancy complications associated with alterations in the functioning of the immune system. The book provides a complete discussion on the immunological aspects of pregnancy and serves as a great tool for research scientists, students, reproductive immunologists and OBGYNs.

Key Features

  • Shows the detailed evaluation of the knowledge related to each immune cell type in the pregnant and not pregnant uterus
  • Evaluates each immune cell type and its function during specific reproductive events
  • Provides the biological background for understanding the clinical aspects that will be discussed in subsequent volumes in the series


Research scientists, students, PhD’s in Immunology and MD’s in reproductive immunology but also in gynecology and obstetrics

Table of Contents

  • 1. The role of the immune system during pregnancy: General concepts
    2. Presentation and recognition of placental, fetal, and pathogen-derived antigens in human pregnancy
    3. Uterine macrophages: Essential roles for a successful human pregnancy
    4. Natural killer cells in reproduction: Before, during and after pregnancy
    5. To B (e) born: New concepts concerning B cells throughout pregnancy
    6. Neutrophils: Diverse functions in the endometrium of cycling women and during pregnancy
    7. Regulatory T cells: Master regulators for the success of pregnancy
    8. Immunology of the decidua
    9. Mechanism of glucocorticoid action in immunology—Basic concepts
    10. Endocrine control of mucosal immunity in the human female reproductive tract: Bridging implantation with pathogen protection
    11. The nature of the immune response in microbial-associated and sterile intraamniotic inflammation
    12. Autoimmunity, regulatory T cells, and pregnancy: Maintaining the balance
    13. Mucosal immunology of the female reproductive tract and its regulation by female sex hormones
    14. Toll-like receptors and NOD-like receptors at the implantation site
    15. Hofbauer cells and placental viral infection
    16. Gamma/delta T cells in pregnancy
    17. Placental regulation of immune functions
    18. TAM receptors in pregnancy
    19. The epigenetic regulation of the immune system during pregnancy
    20. Interactions between the epithelial barrier and the microbiota in the reproductive tract

Product details

  • No. of pages: 460
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: February 12, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128185087
  • eBook ISBN: 9780128189306

About the Editor

Gil Mor

Gil Mor, M.D., Ph.D. is the John M. Malone Jr. MD, Endowed Chair Professor and Scientific Director of The C.S. Mott Center for Human Growth and Development at Wayne State University. Before moving to Wayne State University, he was a Tenured Professor of Obstetrics and Gynecology and Reproductive Science at Yale University School of Medicine. His research topics were related to the immunology of pregnancy and the role of inflammation in cancer formation and progression. He was the Division Director of the Reproductive Science Division at the Department of Obstetrics and Gynecology Yale and directed the Reproductive Immunology Unit and the Translational Research Program “Discovery to Cure.” He was the Editor in Chief of the American Journal of Reproductive Immunology from 2009 to 2019 and is the President of the American Society for Reproductive Immunology. He has been funded by grants from the National Institute of Child Health Development (NICHD), National Cancer Institute (NCI), and National Institute of Allergies and Infectious Diseases (NIAID) as well as by several pharmaceutical companies and is widely published in the area of immunology and reproduction with more than 280 publications and is the editor of three books on “Immunology of pregnancy” and “Apoptosis and Cancer.” He is also the Senior Editor of a book series on Reproductive Immunology with Elsevier. He is the recipient of several national and international prizes, including the Pearl River Professor from Jinan University Guangzhou China, the J. Christian Herr Award, and the AJRI Award from the Society for Reproductive Immunology. He is a member of the American Association for Cancer Research, the Society for Gynecologic Investigation, American Association of Immunologists and the American Society of Reproductive Immunology. He is also a Member of the International Advisory Committee for the Sino-American Center of Translational Medicine. Southern Medical University, China, Guest Professor at Tongji Medical College in Wuhan China and Honorary member and Professor of several scientific societies in Asia, South America, and Europe.

Affiliations and Expertise

John M. Malone Jr., M.D., Endowed Chair, Scientific Director, C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit MI, USA

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