Reproduction: Molecular, Subcellular, and Cellular

Contributors and Presiding Chairmen

Reproduction: Molecular, Subcellular, and Cellular

Introduction

Regulation of Reproductive Mechanisms

Reproduction at the Molecular Level

Transcription and Translation of Genes

ur-Genes and the Gene Action System

References

Structural Basis of the Specificity of Antibodies

Introduction

Dissociation of Rabbit γG-Globulin into Half-Molecules

Spontaneous Reassociation of Half-Molecule Subunits at Neutral pH

Evidence for Univalence of Half-Molecules of Rabbit γG-Globulin

Reversible Dissociation of Fragment Fc

In Vitro Complementation of Polypeptide Subunits of γG-Globulins

Evidence for Antibody Activity in Isolated Heavy Chains

Antibody Activity of Recombined Heavy and Light Chains

Evidence for Direct Participation of Light Chains in the Active Site of an Antibody

Evidence That Differences in Specificity Are Associated with Differences in Amino Acid Sequence

Studies with Myeloma and Bence Jones Proteins

References

Interactions between Plant Viruses and Host Cells

Introduction

Structure and Infectivity of Plant Viruses

Virus Mutation

The Genetic Code

The Size of Cistrons and the Concept of Minimal Infectious Genetic Information

Plant Virus Replication and Some of Its Cellular Events

References

Interaction of Viruses with the Genetic Material of the Host Cells

Introduction

Consequences of Virus Infection for the Genetic Material of Bacterial Cells

Consequences of Virus Infection for the Genetic Material of Animal Cells

References

Reproduction of Subcellular Systems

Chromosome Reproduction in Mitosis and Meiosis

Introduction

Replication As a Process

Chromosome Reproduction

Consequences of Chromosome Reproduction

References

The Continuity of the Chloroplast in Euglena

Introduction—The Two Aspects of Organelle Continuity

The Developmental Aspect of Chloroplast Continuity

The Replicative Aspect of Chloroplast Continuity

Possible Control Mechanisms for Chloroplast Development and Replication

Speculations Concerning the Evolution of the Chloroplast

Conclusion

References

Extrachromosomal Heredity in Fungi

Introduction

Evidence for Extrachromosomal Heredity

The Origins of Extrachromosomal Variability

Phenotypic Effects

Interactions

Discussion

References

Final Remarks: "Why So Much DNA?"

Text

The Reproduction of Cells

Haploidy versus Diploidy in the Reproduction of Cell Type

Introduction

Characteristics of Haploids

Induction of Haploidy

Radiation Effects

Quantitation and Biochemistry

Growth and Differentiation

Haploid Tissue Cultures of Higher Plants

Conclusion

References

Cell and Tissue Interactions in the Reproduction of Cell Type

Introduction

Regulation of Stem Cell Differentiation

The Cellular Environment and Stem Cell Differentiation

Experimental Approaches to Embryonic Induction

Cytodifferentiation in Cell Culture

Population Density and Cytodifferentiation

Conditioned Medium and the Development of Muscle Clones

The Conditioning Process

Biological Parameters of Conditioning

The Critical Period

Conditioning the Petri Plate Surface

Collagen Synthesis during Conditioning

A Hypothetical Role of Conditioned Medium

Macromolecules and Cell Culture

Collagen and Differentiation in Vivo

Summary

References

Aging As a Consequence of Growth Cessation

Introduction

Scope of Aging

Growth and Aging

Animal Aging

Aging of Cells within Animals

Summary

References

Author Index

Subject Index