Regulatory Mechanisms of Carbohydrate Metabolism

Regulatory Mechanisms of Carbohydrate Metabolism

11th Meeting Copenhagen 1977

1st Edition - January 1, 1978

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  • Editor: Viggo Esmann
  • eBook ISBN: 9781483153872

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Description

Regulatory Mechanisms of Carbohydrate Metabolism contains the proceedings of the 11th meeting of the Federation of European Biochemical Societies, held at Copenhagen in 1977. The symposium is attended by thousands of biochemists and their associates to present and discuss the regulatory mechanisms of carbohydrate metabolism. The compendium records the nine sessions of the symposium encompassing 30 chapters of various discussions on the regulatory mechanisms of carbohydrate metabolism. Topics on metabolism of pyruvate in animals; mechanism of insulin secretion; the role of pyruvate in the regulation of carbohydrate metabolism; and control of muscle glycogen metabolism by protein kinases and phosphates are covered. Ketogenesis and carbohydrate metabolism; factors controlling glucagon secretion; and energy homeostasis and the regulation of carbohydrate metabolism are discussed as well. Biochemists, chemists, physicians, pharmacologists, and students of medicine will find this book a good source on insight.

Table of Contents


  • General Introduction to the Proceedings

    Foreword

    Session 1. General Session

    Metabolism of Pyruvate in Animals

    Control of Hepatic Gluconeogenesis and Glucose Output by Glucagon and Insulin

    Mapping the Regulatory Pathways of Glycogen Metabolism in Mammalian Skeletal Muscle

    Mechanism of Insulin Secretion

    Session 2. The Role of Pyruvate in the Regulation of Carbohydrate Metabolism

    Regulation of Liver Pyruvate Kinase by Phosphorylation-Dephosphorylation Reactions

    Pyruvate Transport across Mitochondrial and Plasmamembranes

    Regulation of Heart Muscle Pyruvate Dehydrogenase by Phosphorylation/Dephosphorylation Reactions

    Session 3. The Regulation of Gluconeogenesis

    Hormonal Regulation of Phosphoenolpyruvate Carboxykinase (GTP) Synthesis

    Regulation of Phosphopyruvate Synthesis in Normal and Pathological States

    Session 4. Control of Muscle Glycogen Metabolism by Protein Kinases and Phosphates

    Control of Rabbit Muscle Phosphorylase Phosphatase Activity

    The Role of Calcium Dependent Protein Kinase in the Regulation of Muscle Glycogen Metabolism

    The Role of Glycogen Synthase Kinase 2 in the Regulation of Glycogen Synthase

    Specificities of Synthase Kinases and Phosphatase for the Phosphorylatable Sites in Glycogen Synthase

    Session 5. Ketogenesis and Carbohydrate Metabolism

    Interactions between Ketogenesis and Carbohydrate Metabolism in Rat Liver

    Regulation of Partition of Free Fatty Acids between Triglyceride Synthesis and β-Oxidation in Liver

    Interaction between Ketone-Body and Carbohydrate Metabolism in Peripheral Tissue

    Session 6. Structure and Function of Phosphorylase

    The Crystal Structure of Glycogen Phosphorylase b

    Pyridoxal Phosphate Analogs and Coenzyme Function in Glycogen Phosphorylase

    The Role of Pyridoxalphosphate in Glycogen Phosphorylases

    Session 7. Regulatory Mechanisms in the Secretion of Pancreatic Hormones

    Factors Controlling Glucagon Secretion

    The Use of Glucose Analogues in the Elucidation of the Mechanisms of Insulin Release and Biosynthesis

    Starvation: A Model for the Impaired Stimulus Recognition and Stimulus-Secretion-Coupling in Pancreatic ß-Cells

    Metabolic and Secretory Characteristics of Cultured Human Islets of Langerhans

    Session 8. Energy Homeostasis and the Regulation of Carbohydrate Metabolism

    Regulation of Hepatic Glycolysis and Gluconeogenesis at the Step of Phosphofructokinase/FDPase

    Substrate Cycles in the Control of Energy Metabolism in the Intact Animal

    Phosphorus Nuclear Magnetic Resonance Studies on Perfused Heart

    Session 9. Control of Glycogen Metabolism in Liver

    The Glycoprotein Nature of Liver Glycogen

    cAMP-Mediated and Non-cAMP-Mediated Hormonal Control of Liver Glycogenolysis

    Properties and Regulation of Liver Protein Phosphatases

    Release of Gluconeogenic Precursors from Skeletal Muscle

    Index

Product details

  • No. of pages: 370
  • Language: English
  • Copyright: © Pergamon 1978
  • Published: January 1, 1978
  • Imprint: Pergamon
  • eBook ISBN: 9781483153872

About the Editor

Viggo Esmann

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