Regulatory Mechanisms in Lymphocyte Activation

Regulatory Mechanisms in Lymphocyte Activation

1st Edition - January 1, 1977

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  • Editor: David Lucas
  • eBook ISBN: 9780323142175

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Regulatory Mechanisms in Lymphocyte Activation covers the proceedings of the 11th Leukocyte Culture Conference, held at the Arizona Medical Center, University of Arizona on September 19-23, 1976. The contributors cover the various aspects of the conference theme ""Regulatory Mechanisms in Lymphocyte Activation."" This book is organized into 15 parts encompassing 160 chapters. The three symposium parts discuss the parameters of lymphocyte activation, positive regulation, and suppression. Considerable sections explore the membrane determinants and receptors; major histocompatibility complex; lymphocyte response; and kinetics of DNA synthesis and cell proliferation in lymphocyte activation. Other general topics covered include subpopulations of immune reactive cells, leukocyte separation techniques, cell interactions, and ontogeny of lymphocytes. The remaining parts consider the leukocyte regulatory mechanisms and issues in lymphocytotoxicity. Immunologists and cell biologists will find this book invaluable.

Table of Contents

  • List of Contributors



    Symposium I. Parameters of Activation and Regulation

    An Integrative Approach to Activation and Sequential Metabolic Regulation of the Immune Response

    Catecholamine Hormone Receptors and Cell Division

    The Role of Cation Flux in Triggering and Maintaining the Stimulated State in Lymphocytes

    Parameters of Lymphocyte Activation

    Ribosome Utilization and Regulation of Protein Synthesis during Lymphocyte Activation

    Symposium II. Positive Regulation and Facilitation of Lymphocyte Response

    Role of Adherent Cell Products in the Immune Response

    Genetic Regulation of Macrophage-T Lymphocyte Interaction

    Regulation of B Lymphocytes by T Cell Membrane Gangliosides

    Specific and Non-Specific Activities in Dialyzable Transfer Factor

    Symposium III. Suppression of Lymphocyte Responses

    Maintenance of the Resting State and Potential Regulators of the Proliferative Phase

    Serum Factors Which Suppress the Immune Response

    Suppression of Immune Responses by Products of Activated T Cells

    Dysfunction of Suppressor Mechanisms Associated with Immunodeficiency and Autoimmunity

    Immunosubversive Activity of Tumor Cells as an Escape Mechanism

    Short Papers. Membrane Determinants and Receptors

    T Cell Activation Induced by Cross-Linking of Anti-T Cell Directed Antibodies with Anti-Immunoglobulin

    Concanavalin A Induced Triggering of Allosensitized Memory Lymphocytes into Secondary Cytotoxic Lymphocytes

    Identification and Characterization of the Chemical Moiety of LSP Responsible for C3H/HeJ Spleen Cell Mitogenicity

    Isolation of a Mitogenetic Protein from Wheat Germ with the Same Specificity for the Lymphocyte Membrane as Wheat Germ Agglutinin

    A Receptor for Normal Human Serum Low Density Lipoproteins on Peripheral Blood Lymphocytes

    Characterization of the Mouse Lymphocyte Receptor for Human ß2-Microglobulin

    Mechanism of Anti-µ Induced Suppression of LPS Induced Immunoglobulin Synthesis

    The Mechanism of FC Receptor-Mediated Inhibition of B Lymphocyte Activation by Antigen

    Decreased Responsiveness of Lymphocytes Tagged with Dinitrofluorobenzene (DNFB) to Phytomitogens

    Inhibition of Macrophage-Induced Thymic Lymphocyte Maturation by Cytochalasin B

    The Insulin Receptor on the T Cell: A Marker of Activation after Stimulation

    A Rosette Marker for Mitogen Activated Human Lymphocytes

    Labeling of Human Leukocyte Surface Receptors with Microspheres, in Giemsa Stained Preparations

    Studies on the Human T Lymphocyte—Sheep Erythrocyte Receptor

    Re-Evaluation of Receptors for IgG on Human Lymphocytes

    Rabbit T and B Lymphocytes: Surface Markers and Functional Characteristics

    Reactions of Human Peripheral Blood Lymphocytes with C5b-9 Complement Complex-Specific Antibodies

    Identification of Human Lymphocyte Subpopulations by Rapid Microrosette Technique

    Separation Methods, Surface Markers, and Cytotoxic Capabilities of Human Eosinophils

    Effect of Ficoll-Hypaque Separation on Activation and DNA Synthesis of Human Blood Lymphocytes

    Augmentation of in Vitro Generated Cell Mediated Cytotoxicity by Neuraminidase

    Isolation of Tumor Associated Antigen(s) from a Moloney Virus Induced Leukemia (MBL-2)

    Short Papers. Major Histocompatibility Complex

    Expression of H-2 Specificities and of MuLV Envelope Antigens on Murine Tumors

    Antigen Mapping for T Cell Recogniton: Immune Response Gene Control of Determinant Selection

    Specificity of Anamnestic Responsiveness in Vitro to Antigens under Histocompatibility-linked IR Gene Control in Rats

    The TYN-PLOP Phenomenon in HLA-D Typing

    MLR Inhibition, HLA-D Typing Using Homozygous Typing Cells and in Vitro Primed Lymphocytes versus a B Cell Specific Antigenic System

    Primed LD Typing: Analysis of the HLA-D Complex

    In Vitro Stimulation of Ur primed Lymphocytes by Allogeneic

    Semi-Soluble Lymphocyte Membrane Fragments

    The Primed Canine MLC: Allograft Immunity in Vitro

    Primary in Vitro Sensitization of Isogeneic and Allogeneic

    Murine Lymphocytes to Normal and SV40-Transformed BALB/c 3T3 Cells

    Extraction of la-Like Antigen from Cultured Human B

    Lymphoblasts and Its Expression on Leukemic Cells

    Workshop Report. H-2 Restriction of T Cell Function

    Short Papers. Lymphocyte Response

    Processing of LPS by Cells Competent to Respond: Conversion to a Low Molecular Weight Form Strongly Mitogenic for C3H/HeJ Low Responders

    Mitogenicity of Derivatives of the Iipoprotein from the Outer Membrane of Escherichia Coli

    Lymphocyte Surface Glycosyltransferases

    Functional Mosaicism of the Lymphocyte Plasma Membrane

    The Specificity of Con A-Induced Decrease in Lymphocyte Potassium

    Transmembrane K+ Turnover by Phytohemagluttinin (PHA)-Stimulated Human Lymphocytes

    Differential Alteration of Membrane Transport in Non-Adherent Spleen Cells from Con-A Stimulated Mice

    Effect of the Ionophore A23187 upon Lymphocyte Calcium Metabolism

    Changes in the Iipid Components of Stimulated Human Lymphocytes

    Fc Receptor Mediated Increases in Intracellular cAMP

    A Single Second Signal for Mitogenesis?

    Synthesis of Albumin by Rabbit Lymphoid Cells

    In Vitro Modulation of Phytohemagglutinin-P Induced Blastogenesis by Parathyroid Hormone

    Evidence for an Early Sulfhydryl Reagent Sensitive Step during Lymphocyte Activation

    Factors Influencing Stimulation and Proliferation in Mitogen Stimulated Thymocytes

    Factors Affecting the Measurement and Interpretation of in Vitro Lymphocyte Reactivity

    Pitfalls in the Lymphocyte Proliferation Assay: Variations in Proliferation Kinetics and Cold Thymidine Pools

    Is There Gene Amplification or Other Nonduplicative DNA Synthesis in Human Lymphocyte Activation?

    Cellular Cooperation in the Release of DNA by Human Lymphocytes

    Intermediates of DNA Synthesis of Mouse Thymocytes

    Workshop Report. Kinetics of Dna Synthesis and Cell Proliferation in Lymphocyte Activation

    Short Papers. Subpopulations of Immune Reactive Cells

    Analysis of Surface Properties, Fine Structure and Organ

    Distribution of Two Distinct T-Cell Subpopulations: Tµ and Ty

    Proliferative Responsiveness of Two Distinct Human T-Cell Subpopulations to Con A, PHA and Alloantigens

    Separation of Tumor Enhancing Murine Thymocytes by Agglutination with a Peanut Lectin (PNA)

    Spontaneous Cytotoxicity by Human Peripheral Blood Lymphocytes

    Studies of Monocyte Fc Receptor Avidity and Monocyte Mediated Antibody Dependent Cellular Cytotoxicity (MMADCC) in Man

    Binding of Immunoglobulin-Bearing Lymphoid Cells to Allogeneic and Synegeneic Target Cells

    Antibody Dependent Cell Mediated Cytotoxicity (ADCC) in Severe Combined Immunodeficiency (SCID)

    Characterization of the Effector Cell in an Antibody Dependent Cell Mediated Cytotoxicity System

    Regeneration and Proliferation in Vitro of Cytolytic T Lymphocytes Specific for MSV-Associated Tumor Antigens

    Cytotoxicity of Human Lymphocytes in Cell-Mediated Lympholysis (CML) and Antibody-Dependent Lymphocytotoxicity (ADL)

    Different Mechanisms for Natural Killer (NK) and Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) by Fc-Receptor Bearing Lymphocytes

    In Vitro Induction of Natural Killer (NK) and Killer (K) Cells

    Is There a Relationship between Effector-Target Cell Binding and Cell-Mediated Cytotoxicity?

    Mechanisms of Target Cell Killing by Activated Lymphocytes in Vitro

    Identification of Lymphotoxin (LT) As the Mediator of Direct Cytolysis of L-929 Cells by Mitogen Activated Human Lymphocytes in Vitro

    Fractionation of Human Lymphocytes on Linear Density Gradients

    Primary in vitro Antibody Response from Human Peripheral Blood Lymphocytes

    Plaque Forming Cell Assay for the Measurement of Polyclonal Activation of Human Peripheral Blood Lymphocytes. Cellular Requirements and Interactions

    Effect of Antigen on Localization of Immunologically Specific B Cells

    Identification of Five Human Lymphocyte Subpopulations by Differential Labeling with Bacteria

    The Toxicity of Cyclophosphamide for T and B Cells

    In Vitro Growth of Canine and Murine Granulocyte-Monocyte, Fibroblast and Lymphocyte Colonies: Preliminary Results

    Workshop Report. Leukocyte Separation Techniques

    A Critique of Techniques of Macrophage-Monocyte Depletion in Studies of Human Peripheral Blood Mononuclear Leukocyte (MNL) Function

    Technical Considerations for the Separation of Human Peripheral Blood Lymphocyte Subpoputations by Rosetting with Sheep Erythrocyte

    Modifications of Anti-Fab Immunoabsorbent Separation of Human Peripheral Blood Mononuclear Cells

    Separation of Human Lymphocytes by Their FC Receptor

    Workshop Conclusions

    Short Papers. Cell Interactions

    Generation of Cytotoxic T Cells Requires Antigen-Specific Helper T Cells

    In Vitro Induction and Assay of Helper T-Cells Using Unprimed Purified Mouse Cell Populations

    Periodate-Induced Blast Transformation in Mixtures of Rat Lymphoid Cells

    Enhancement of Weak MLC Type Reactions by Hydiophilic Polymers

    Role of Rat Lymphocyte Subpopulations in the Mixed Lymphocyte Culture (MLC)

    Inhibition of the Human Mixed Lymphocyte Culture (MLC) Interaction by Cytotoxic Agents Conjugated to Anti-Lymphocyte Globulin

    Virus-Macrophage-Lymphocyte Interactions

    Workshop Report. Macrophage-Lymphocyte Interaction

    Short Papers. Ontogeny of Lymphocytes

    Thymosin-Induced Enhancement of MIF Production by Peripheral Blood Lymphocytes of Thymectomized Guinea Pigs

    T Cell Function in Congenitally Asplenic (Dh/+) Mice

    Interactions of Human Neonatal T and B Lymphocytes and Evidence for Functional Immaturity

    Cell-Mediated Lympholysis by Human Neonatal Lymphocytes

    To the Question of Null Cells in the Avian Bursa of Fabricius

    Short Papers. Regulatory Mechanisms

    Spontaneous Cytotoxicity by Human Peripheral Blood Lymphocytes Due to a Time Dependent Loss of Suppressor Cells

    Regeneration of Effector Function in Vitro

    Role of H-2 CD Antigens in Secondary Responses

    Analysis of Secondary MLR by Titration of in Vitro Primed Human Lymphocytes

    Enhancement of Pinocytosis in the Macrophage by Macrophage Activating Factor

    Migration of Normal Human Lymphocytes Cultured in the Presence of Candida Albicans Extract

    Mechanism of Leukocyte Adherence Inhibition

    Modulation of Human EA Rosette Formation and Antibody-Dependent Cell-Mediated Cytotoxicity by Promethazine and Agents Which Alter Cyclic Nucleotide Levels

    Cellular Cytotoxicity Induced by Calcium Ionophore A23187

    The Role of Opsonins in Phagocytosis and Intracellular Killing of Gram-Negative Bacteria by Human Polymorphonuclear Leukocytes (PMN)

    Spontaneous Lymphocyte Proliferation in Hodgkin's Disease

    Activation of Isolated T Cells in Chronic Lymphocytic Leukemia (CLL) by Mitogens

    Purine Metabolism in Severe Combined Immunodeficiency

    Production in MLC Reaction as a Measure of Immunocompetence in Immunodeficiency Diseases

    Further Characterization of Neoplastic Helper T Cells from

    Patients with the Sdzary Syndrome

    Adjuvant Properties in Human Dialysable Leukocyte Extracts (DLE) Containing Transfer Factor

    Interaction of Dextran-Triggered Murine Splenic Cell Supernatants and Allogeneic Effect Factor

    T-Cell Mediator Induction of Non-T Cell Cytotoxicity

    Anti-IgD (ä) and F(ab')2 Anti-IgD Activated B Cells Enhance PHA Responsiveness

    Kinetics of the Potentiation of DNA Synthesis by "Lymphocyte Activating Factor"

    Stimulation of Human Lymphocytes: Activation by a Sodium Periodate Induced Growth Factor

    The Effect of Various Thymic Extracts on the in Vitro Immune Response against SRBC and on Mitogen Responses and IntracellularcAMP Levels of T Cells

    Suppression of the Immune Response to UV Induced Tumors by UV Light

    Effect of Cyclosporin A on Murine Lymphoid Cells

    Failure of Levamisole to Stimulate Humoral or Cellular Immunity to Sheep Erythrocytes in Normal or T Cell Deprived Mice

    Human Monocyte-Lymphocyte Interaction Mediated by Concanavalin A: The Effect of Levamisole

    Nonspecific Suppression of the Initiation of the Primary Immune Response in Vitro

    Regulation of Autoimmunity by the Mode of Presentation of Autoantigen to Lymphocytes

    Serum Factors Affecting the Incorporation of [3H] Thymidine by Lymphocytes Stimulated by Aptigen: Increased Divergence between Antigen Dose-Response Curves in Heated and Control Serum with Cells from Rabbits Immunized to Increase the Proportion of High Specificity Cells

    Suppression of the in Vivo Humoral Immune Response by a Species of Normal Human Serum Low Density lipoprotein

    The Bioregulatory Properties of Serum Low Density lipoprotein Inhibitor (LDL-IN) on the Generation of Killer T Cells

    Inhibition of Antigen-Induced Human Lymphocyte Proliferation by Daudi Cell Line Supernatant

    Naturally Tolerant Pigs—Reactivity of Peripheral Blood Lymphocytes (PBL) in Mixed Lymphocyte Culture (MLC) and Cell Mediated Cytolysis (CMC)

    Two Distinct Human T-Cell Subpopulations: Suppressor Activity on PWM-Induced B-Cell Differentiation Is Restricted to T Cells Bearing Fc-IgG Receptors

    Heterogeneity among Suppressor T Cells

    The Persistence of in Vivo and in Vitro Immune Responses in Thymectomized Rabbits

    Evidence for T Suppressor Cell Function in a Thymus Independent Mitogenic Response to Lipopolysaccharide

    Regulation of the Immune Response of Rabbit Lymphocytes by Antigen Activated Suppressor Cells

    In Vitro Generation of Specific and Non-Specific Suppression of Cell Mediated Cytotoxicity (CMC)

    Radiation Sensitivity of the Mechanism Inducing Non-Specific Desensitization (Anergy) in Guinea Pigs

    Inhibition by Measles Virus of Lymphocyte Stimulation in Vitro

    Suppression of the HGG Response in Normal Mice with a Spleen Cell Lysate from Tolerant Mice

    Evidence for Aberrant Immunoregulation of NZB Autoantibody-Secreting Precursor B Lymphocytes

    Failure of Concanavalin A-Stimulated Lymphocytes to Suppress Responsiveness to PHA and Allogeneic Cells as a Marker of Disordered Immunoregulation

    Immunoglobulin Class Specific Suppressor T Cells

    Enhancement of PGEi Sensitivity in Macrophages

    A Comparison of Alveolar and Peritoneal Macrophages as Accessory Cells in PHA Induced Proliferation of Guinea Pig Lymphocytes

    Adherent Cell Populations and the Responses to PHA, Con A, and PPD

    The Effect of Macrophages on TdR Incorporation into Mitogen Stimulated Rat Lymphocytes

    Macrophage-Monocyte Regulation of the Mitogenic Activation of X-Rayed, Purified Human T Lymphocytes

    Macrophage Mediated Inhibition of Mitogen-Induced Lymphocyte Blastogenesis in Mice

    Adherent Suppressor Cells in Normal Rat Spleens

    Characterization of the Adherent Splenic Suppressor Cells

    Presence of Splenic Suppressor Cells in Allograft Enhanced Rats

    Workshop Report. Recent Advances and Questions in Lymphocytotoxicity

    Workshop Report. Suppression


Product details

  • No. of pages: 862
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 1, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323142175

About the Editor

David Lucas

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