Regulation of Organelle and Cell Compartment Signaling

1st Edition

Cell Signaling Collection


  • Edward A. Dennis
  • Ralph Bradshaw
  • Regulation of Organelle and Cell Compartment Signaling

    Print book


     In Stock

    Add to Cart


    This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles.

    Key Features

    • Articles written and edited by experts in the field
    • Thematic volume covering regulation of endoplasmic reticulum function, regulation of cell cycle progression, and quality control and assurance in mitochondrion events
    • Up-to-date research on events in membrane proteins and proteins of intracellular matrix


    Professionals, researchers and graduate students in molecular biology, biochemistry, cell biology, biomedicine, structural biology, systems biology, and genetics.

    Table of Contents

    244 Nuclear Receptor Coactivators

    245 Corepressors in Mediating Repression by Nuclear Receptors

    246 Steroid Hormone Receptor Signaling

    247 Role of COUP-TFII in Congenital Diaphragmatic Hernia

    248 Nuclear Receptors in Drosophila melanogaster

    249 JAK-STAT Signaling

    250 FOXO Transcription Factors: Key Targets of the PI3K-Akt Pathway

    251 The Multi-gene Family of Transcription Factor AP-1

    252 NF-KB: a Key Integrator of Cell Signaling

    253 Transcriptional Regulation via the cAMP Responsive Activator CREB

    254 The NFAT Family: Structure, Regulation and Biological Functions

    255 Ubiquitination/Proteasome

    256 The SMADs

    257 Complexity of Stress Signaling

    258 Signal Transduction in the Escherichia coli SOS Response

    259 Oxidative Stress and Free Radical Signal Transduction

    260 Screening Approaches to Identify Genes Required for DNA Double-Strand Break

    261 Radiation Responses in Drosophila

    262 Double-strand Break Recognition and its Repair by Non-homologous End Joining

    263 ATM-Mediated Signaling Defends the Integrity of the Genome

    264 Signaling to the p53 Tumor Suppressor through Pathways

    265 The p53 Master Regulator and Rules of Engagement with Target Sequences

    266 Nuclear and Cytoplasmic Functions of Abl Tyrosine Kinase

    267 Radiation-induced Cytoplasmic Signaling

    268 The Heat-Shock Response and the Stress of Misfolded Proteins

    269 Hypoxia-Mediated Signaling Pathways

    270 Regulation of mRNA Turnover by Cellular Stress

    271 Oncogenic Stress Responses

    272 Ubiquitin and FANC Stress Responses

    273 Stress and g -H2AX

    274 Translational Control by Amino Acids and Energy

    275 Translation Control and Insulin Signaling

    276 ER and oxidative stress: Implications in disease

    277 Regulation of mRNA Turnover

    278 Signaling


    No. of pages:
    © 2011
    Academic Press
    Print ISBN:
    Electronic ISBN:

    About the authors

    Edward A. Dennis

    Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

    Ralph Bradshaw

    Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University School of Medicine in St. Louis, MO and was Professor and Chair of the Department of Biological Chemistry at the University of California, Irvine. From 2006 to 2015, he was a member of the Mass Spectrometry Facility and Professor of Pharmaceutical Chemistry at the University of California, San Francisco. He holds degrees from Colby College and Duke University and was a post-doctoral fellow at Indiana University and the University of Washington. He has served as president for FASEB, was the founding president of the Protein Society and was the treasurer of the American Society for Biochemistry and Molecular Biology. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signalling. He has also studied in the role of proteolytic processing and N-terminal modification in protein stability and turnover.


    "In order to keep researchers and students up to date on developments in the field, 55 articles were selected and reprinted from the 2008 second edition of the ‘Handbook of Cell Signaling’ on the transcriptional regulation and the function of nuclei and other subcellular organelles in signaling activities. After an overview, they cover nuclear signaling in transcription, chromatic remodeling, and stress response; signaling to and from intracellular compartments; and cell cycle and cell death signaling. This is one of four volumes of such reprints, called the Cell Signaling Collection."--Reference and Research Book News