Regulation of matrix Accumulation

Regulation of matrix Accumulation

1st Edition - May 5, 1986

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  • Editor: Robert Mecham
  • eBook ISBN: 9780323149006

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Regulation of Matrix Accumulation discusses the development of research and studies on connective tissue. This book emphasizes biochemical characterization of individual connective tissue components and interactions between cells and extracellular macromolecules. Other topics include the intracellular turnover of collagen; biological regulation of collagenase activity; feedback regulation of collagen synthesis; steroid hormone regulation of extracellular matrix proteins; and control of elastin synthesis, including its molecular and cellular aspects. The catalytic and biological properties of elastases; characterization and regulation of lysyl oxidase; and matrix accumulation and the development of form, considering proteoglycans and branching morphogenesis, are explained as well. Included in this text is an autobiography and personal retrospective by Miles Partridge, one of the contributors that greatly influenced the progress in understanding extracellular matrix biology. This publication is a good reference for students and researchers conducting work on biology, specifically on connective tissue.

Table of Contents

  • Contributors


    Reflections on a Career in Connective Tissue Research



    Intracellular Turnover of Collagen


    II. Biosynthesis

    III. Proteolytic Processing of Secretory Proteins

    IV. Role of Intracellular Proteinases in Maintaining Collagen Synthesis

    V. Degradation of Secretory Proteins: Collagen

    VI. Regulation of Collagen Production by Changes in Intracellular Degradation


    The Biological Regulation of Collagenase Activity

    I Introduction

    II. Regulatory Aspects of Molecules Intrinsic to the Collagenolytic System

    III. Extrinsic Regulation of Collagenase Activity: A Selective Survey of Collagenolytic Systems and Their Regulation

    IV. Summary and Future Perspective


    Feedback Regulation of Collagen Synthesis

    I. Introduction

    II. The Aminopropeptides

    III. Experiments on Feedback Inhibition of Aminopropeptides on Collagen Biosynthesis

    IV. Clinical Importance of Collagen Feedback Regulation


    Steroid Hormone Regulation of Extracellular Matrix Proteins


    II. Glucocorticoid Regulation of Collagen Metabolism in Tissues

    III. Glucocorticoid Regulation of Collagen Metabolism in Cells

    IV. Sex Hormone Regulation of Collagen Metabolism in Tissues

    V. Sex Hormone Regulation of Collagen Metabolism in Cells

    VI. Glucocorticoid Regulation of Elastin Metabolism in Tissues

    VII. Glucocorticoid Regulation of Elastin Metabolism in Cells

    VIII. Sex Hormone Regulation of Elastin Metabolism in Vascular Tissue

    IX. Steroid Hormone Regulation of Fibronectin Metabolism in Liver and Cells

    X. Future Prospectives of Steroid Hormone Regulation of the Synthesis of the Proteinaceous Components of the Extracellular Matrix


    Control of Elastin Synthesis: Molecular and Cellular Aspects

    I. Introduction

    II. Molecular Biology

    III. Biosynthesis and Secretion

    IV. Assembly of Elastic Fibers

    V. Regulation of Production

    VI. Evolution of Elastin

    VII. Summary and Perspectives


    Elastases: Catalytic and Biological Properties

    I. Introduction

    II. Definition and Occurrence

    III. Pancreatic Elastases: Occurrence and Molecular Properties

    IV. Leukocyte Elastases: Occurrence and Molecular Properties

    V. Catalytic Properties of Pancreatic and Leukocyte Elastases

    VI. Pancreatic and Leukocyte Elastase Inhibitors

    VII. Other Mammalian Elastases

    VIII. Nonmammalian Elastases

    IX. Assay of Elastases: A Critical Minireview

    X. Pathological Role of Elastases

    XI. Elastase Inhibitors as Potential Drugs

    XII. Concluding Remarks


    Characterization and Regulation of Lysyl Oxidase

    I. Introduction

    II. Posttranslational Modifications of Connective Tissue Proteins

    III. Assay and Purification of Lysyl Oxidase

    IV. Physical Properties

    V. Catalytic Properties

    VI. Pathology

    VII. Physiological Control of Lysyl Oxidase

    VIII. Summary and Prospects


    Matrix Accumulation and the Development of Form: Proteoglycans and Branching Morphogenesis


    II. Branching Morphogenesis

    III. Proteoglycans and Hyaluronic Acid

    IV. Proteoglycans and Hyaluronate in Branching Organs

    V. Effects of ß-D-Xyloside

    VI. Basal Lamina in Branching Morphogenesis

    VII. Possible Functions of Proteoglycans in Branching Morphogenesis



Product details

  • No. of pages: 476
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: May 5, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323149006

About the Series Editor

Robert Mecham

Affiliations and Expertise

Washington University, St. Louis, Missouri, U.S.A.

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