Regulation of Macromolecular Synthesis By Low Molecular Weight Mediators - 1st Edition - ISBN: 9780124175808, 9780323152556

Regulation of Macromolecular Synthesis By Low Molecular Weight Mediators

1st Edition

Editors: Gebhard Koch
eBook ISBN: 9780323152556
Imprint: Academic Press
Published Date: 1st January 1979
Page Count: 390
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Description

Regulation of Macromolecular Synthesis by Low Molecular Weight Mediators contains the proceedings of the Workshop on Regulation of Macromolecular Synthesis by Low Molecular Weight Mediators held at Hamburg on May 29-31, 1979. The book discusses the functions and metabolism of guanosine 3',5'-bis(diphosphate); the purine nucleotides and sporulation; and the highly phosphorylated nucleotide in eukaryotes. The text also describes the alteration of translational mechanisms, as well as 2,5-oligoadenylic acid and interferon.

Table of Contents


Contributors


Foreword


Preface


Opening Remarks:


Oligonucleotides and Growth Regulation


I. Functions and Metabolism of Guanosine 3',5'-Bis(Diphosphate) [ppGpp]


1. Stringent Control In Bacterial Systems


Stringent Control of Translational Accuracy


Guanosine 3,5'-Bispyrophosphate is a Dispensable Metabolite


Studies on the Coordination of tRNA-Charging and Polypeptide Synthesis Activity in Escherichia Coli


Deletion of relA and relX in Escherichia Coli has no Effect on Basal or Carbon-Downshift ppGpp Synthesis


2. Effect of ppGpp on RNA Polymerase and Transcription in E. Coli


Molecular Interactions in the Initiation of rRNA Synthesis in Prokaryotes


The Regulation of RNA Polymerase by Guanosine 5'-Disphosphate 3'-Diphosphate


3. Metabolism of ppGpp In Cell-Free Bacterial Systems


Synthesis and Degradation of the Pleiotropic Effector Guanosine 3',-5'Bis(Disphosphate) in Bacteria


Biosynthesis of Guanosine Tetraphosphate in Bacillus Brevis


4. Failure to Detect ppGpp In Eukaryotes


A Radioimmunoassay for ppGpp


Guanosine 3',5'-Bis (Diphosphate) Search in Eukaryotes


II. Purine Nucleotides and Sporulation


Initiation of Bacterial and Yeast Sporulation by Partial Deprivation of Guanine Nucleotides


Regulation of Sporulation by Highly Phosphorylated Nucleotides in Bacillus Subtilis


III. Highly Phosphorylated Nucleotides in Eukaryotes


1. Isolation and Characterization of Novel Dinucleotides


Studies on the Biosynthesis and Function of Dinucleoside Polyphosphates in Artemia Embryos


Historical Background on Adenosine 5,5'-P1,P4-Tetraphosphate (Ap4A) and Current Developments


The Accumulati

Details

No. of pages:
390
Language:
English
Copyright:
© Academic Press 1979
Published:
Imprint:
Academic Press
eBook ISBN:
9780323152556

About the Editor

Gebhard Koch

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