Regenerative Nephrology - 1st Edition - ISBN: 9780123809285, 9780123809292

Regenerative Nephrology

1st Edition

eBook ISBN: 9780123809292
Hardcover ISBN: 9780123809285
Paperback ISBN: 9780128101964
Imprint: Academic Press
Published Date: 20th October 2010
Page Count: 442
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.

Key Features

  • Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers
  • Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney


Medical and pharmaceutical researchers in nephrology and related renal diseases; fellows and academic clinicians in nephrology; biomedical researchers who work with stem cells

Table of Contents


  1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach
  2. Yuko Wakamatsu and Hisashi Hashimoto

  3. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia
  4. Marc R. Hammerman

  5. Use of Genetic Mouse Models to study Kidney Regeneration
  6. Akio Kobayashi and Jeremy S. Duffield


  7. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease
  8. Charles N. Serhan and Catherine Godson

  9. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides Danilo Fliser
  10. Mast cells in kidney regeneration
  11. Eric Daugas, Walid Beghdadi and Ulrich Blank

  12. Role of macrophages in renal injury, repair and regeneration
  13. Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris

  14. T-cells contribution to regenerative processes
  15. Hamid Rabb


  16. MSC and reparative processes
  17. Benjamin D. Humphreys and John V. Bonventre

  18. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney
  19. Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink

  20. The potential of the side population in regenerative nephrology
  21. Melissa H. Little and G. A. Challen

  22. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis
  23. Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak

  24. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells
  25. Kenji Osafune and Shinya Yamanaka

  26. Methods of Isolation and Culture of Adult Stem cells
  27. Lindolfo da Silva Meirelles and Nance Beyer Nardi


  28. Stem cell niche in the kidney
  29. Laura Lasagni, Elena Lazzeri and Paola Romagnani

  30. Creation of artificial niches
  31. Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky

  32. Imaging of transplanted and native stem cells
  33. Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman


  34. Stem cell injury and premature senescence
  35. Michael S. Goligorsky

  36. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway
  37. Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering

  39. Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi


  40. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data
  41. Florian E. Tögel and Christof Westenfelder

  42. Clinical trials in Renal Regenerative Medicine
  43. Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar

  44. Potential risks of stem cell therapies
  45. Uta Kunter and Jürgen Floege

  46. Tissue engineering in urology
  47. Anthony Atala

  48. Ethical issues in SC therapy
  49. Donald W. Landry

  50. Stem Cell Banking

Vicente Mirabet and Pilar Solves


No. of pages:
© Academic Press 2011
Academic Press
eBook ISBN:
Hardcover ISBN:
Paperback ISBN:


"The authors of Regenerative Nephrology have empowered a group of the leading investigators to provide a comprehensive overview of regenerative processes in the kidney. It spans the subject from cellular physiology to models and the first clinical trials of stem cell therapy. This book fills a gap in this rapidly expanding field. It will be an invaluable reference to the specialist investigator and a useful overview for those in nephrology or regenerative medicine who wish to become fully up to date with this important subject." --Christopher S. Wilcox, MD, PhD, George E. Schreiner Chair of Nephrology,Director, Center for Hypertension, Kidney and Vascular Health, Chief, Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC, USA

"Dr. Goligorsky has assembled an outstanding group of authors for his "Regenerative Nephrology" book. The publication of this authoritative work is timely. State-of-the-art knowledge about the phylogeny, ontogeny, and mediators of tissue regeneration is discussed and is critical in pursuing the potential role of stem cells in regenerative processes. The kidney is the organ responsible for total body homeostasis, therefore focusing on regeneration in acute and chronic kidney disease is very appropriate. Moreover, Goligorsky is an internationally prominent researcher in understanding the pathophysiology of kidney disease. Regenerative Nephrology has important sections dealing with the clinical aspects of stem cell therapy including potential risks and ethical issues. I highly recommend this important book, not just for scientists studying the kidney, but for all biomedical scientists, as the dawn of stem cell therapy in humans is emerging for many organs." --Robert W. Schrier, MD, Professor of Medicine, University of Colorado, School of Medicine, Denver, CO, USA

"With this book, Dr Goligorsky, along with his impressive collection of highly prominent authors, has certainly succeeded in achieving the goal of bringing an up-to-date review of the basic research of regenerative nephrology and its promising clinical applications to the attention of the interested reader. This is a truly international book; although the majority of the outstanding faculty is North American, excellent contributions have been written by Japanese, Australian and European authors…. This book is not only of interest to the basic expert investigator. Also, the interested teacher or clinician who wants to catch a glimpse of what will become possible in the near future in the treatment of a whole range of acute and chronic kidney diseases with these fascinating new tools will find this book a must…. Dr Goligorsky and his contributors have done a great service to most of us ‘non-experts’ by summarizing, in a brilliant manner, the recent advances in this field." --NDT Plus

Ratings and Reviews