Regenerative Nephrology
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Regenerative Nephrology

1st Edition - October 20, 2010

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  • Editor: Michael Goligorsky
  • Paperback ISBN: 9780128101964
  • eBook ISBN: 9780123809292

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Description

Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.

Key Features

  • Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers
  • Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Readership

Medical and pharmaceutical researchers in nephrology and related renal diseases; fellows and academic clinicians in nephrology; biomedical researchers who work with stem cells

Table of Contents

  • PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION
    1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach
    Yuko Wakamatsu and Hisashi Hashimoto
    2. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia
    Marc R. Hammerman
    3. Use of Genetic Mouse Models to study Kidney Regeneration
    Akio Kobayashi and Jeremy S. Duffield

    MEDIATORS OF REGENERATION
    4. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease
    Charles N. Serhan and Catherine Godson
    5. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides
    Danilo Fliser
    6. Mast cells in kidney regeneration
    Eric Daugas, Walid Beghdadi and Ulrich Blank
    7. Role of macrophages in renal injury, repair and regeneration
    Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris
    8. T-cells contribution to regenerative processes
    Hamid Rabb

    STEM CELLS IN REGENERATIVE PROCESSES
    9. MSC and reparative processes
    Benjamin D. Humphreys and John V. Bonventre
    10. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney
    Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink
    11. The potential of the side population in regenerative nephrology
    Melissa H. Little and G. A. Challen
    12. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis
    Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak
    13. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells
    Kenji Osafune and Shinya Yamanaka
    14. Methods of Isolation and Culture of Adult Stem cells
    Lindolfo da Silva Meirelles and Nance Beyer Nardi

    STEM CELLS - FROM THE NICHE TO REPAIR
    15. Stem cell niche in the kidney
    Laura Lasagni, Elena Lazzeri and Paola Romagnani
    16. Creation of artificial niches
    Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky
    17. Imaging of transplanted and native stem cells
    Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman

    CAUSES OF REGENERATIVE FAILURE
    16. Stem cell injury and premature senescence
    Michael S. Goligorsky
    17. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway
    Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering
    18. Bone marrow-mesenchymal stem cells in organ repair and strategies to optimize their efficacy
    Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi

    EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY
    19. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data
    Florian E. Tögel and Christof Westenfelder
    20. Clinical trials in Renal Regenerative Medicine
    Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar
    21. Potential risks of stem cell therapies
    Uta Kunter and Jürgen Floege
    22. Tissue engineering in urology
    Anthony Atala
    23. Ethical issues in SC therapy
    Donald W. Landry
    24. Stem Cell Banking
    Vicente Mirabet and Pilar Solves

Product details

  • No. of pages: 442
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: October 20, 2010
  • Imprint: Academic Press
  • Paperback ISBN: 9780128101964
  • eBook ISBN: 9780123809292

About the Editor

Michael Goligorsky

Michael S. Goligorsky, MD. PhD, holds the Alvin I. Goodman Chair in Nephrology, and is Professor of Medicine, Pharmacology and Physiology and Director of Renal Research Institute at the New York Medical College, Touro University. Dr. Goligorsky serves as an Associate Editor for Am J Pathology and is a member of the Association of American Physicians (elected 2002). His research interests include: the mechanisms of endothelial dysfunction as a harbinger of diabetic, and hypertensive vascular damage; stress-induced premature senescence of endothelial cells and the role of lysosomal dysfunction in this process; mechanisms of functional incompetence of endothelial cells in chronic kidney disease; and mechanisms of alarm signaling by an ischemic kidney.

Affiliations and Expertise

Alvin I. Goodman Chair in Nephrology, Professor of Medicine, Pharmacology and Physiology, Academic Chief of Renal Division, and Director of Renal Research Institute, New York Medical College, NY, USA

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