Reflections on Biochemistry

Reflections on Biochemistry

In Honour of Severo Ochoa

1st Edition - January 1, 1976

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  • Editors: A. Kornberg, B. L. Horecker, L. Cornudella
  • eBook ISBN: 9781483136028

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Reflections on Biochemistry: In Honour of Severo Ochoa offers reflections on a wide range of topics relating to biochemistry, including energy metabolism, lipids and saccharides, regulation, nucleic acids and the genetic code, protein biosynthesis, and cell biology. The essays celebrate Severo Ochoa's outstanding contributions to biochemistry spanning nearly half a century. This book is comprised of 47 chapters and begins with a biography of Ochoa and his scientific work in the field of biochemistry, particularly his research on intermediary metabolism, RNA synthesis, and the genetic code. The discussion then turns to energy metabolism, photosynthesis, and fermentation, touching on topics such as the role of lactic acid in the development of biochemistry and the biosynthesis of cell components from acetate. The next section is devoted to lipids, saccharides, and cell walls and includes chapters that deal with biotin, sulfur biochemistry, and dipicolinic acid. Subsequent chapters explore hormonal regulation of adipose tissue lipolysis; the structural relationship between genes and enzymes; bacteriophages, colicins, and ribosomes; and cell biology and neurobiology. This monograph will be of interest to biochemists and students of biochemistry.

Table of Contents

  • Biographical Introduction: Severo Ochoa and the Development of Biochemistry

    I. Energy Metabolism, Photosynthesis, Fermentation

    The Role of Lactic Acid in the Development of Biochemistry

    Origins of the Concept of Oxidative Phosphorylation: Retrospectives and Perspectives

    Reflections on the Evolutionary Transition from Prokaryotes to Eukaryotes

    A Pathway from Psychiatry to Cancer

    Bioenergetics: Past, Present and Future

    Enzymes Revisited

    Unraveling the Pentose Phosphate Pathway

    Reducing Power and the Regulation of Photosynthesis

    Studies on High-Energy Phosphate Bonds: From Biosynthetic to Mechanochemical Reactions

    Glutamate Fermentation and the Discovery of B12 Coenzymes

    Trailing the Propionic Acid Bacteria

    Biosynthesis of Cell Components from Acetate

    Lessons in Learning

    The Impact of the ATP-Generating Systems

    II. Lipids, Saccharides, Cell Walls

    On the Evolution of a Biosynthetic Pathway

    My Expeditions into Sulfur Biochemistry

    The Clostridium kluyveri-Acetyl-CoA Epoch

    Biotin Unmasked

    The Seven Veils of Dipicolinic Acid

    Enzymic Mechanisms Involved in the Synthesis of Yeast Cell Wall

    III. Regulation

    The Pasteur Effect in the Allosteric Era

    Comparative Aspects of Hormonal Regulation of Adipose Tissue Lipolysis

    Reflections on the Relevance of Biochemistry for the Understanding of Living Systems

    Formation and Cleavage of C—N Bonds in Arginine Biosynthesis and Urea Formation

    Molecular Ecology

    IV. Nucleic Acids and the Genetic Code

    For the Love of Enzymes

    From Enzyme Chemistry to Genetic Manipulation

    The Search for the Structural Relationship between Gene and Enzyme

    Synthesis in the Study of Nucleic Acids

    A Phage in New York

    Bacteriophage ø29

    V. Protein Biosynthesis

    Protein Synthesis: Early Waves and Recent Ripples

    Ten Years in Protein Synthesis

    Bacteriophages, Colicins and Ribosomes: Some Reflections on my Research Career

    Ribosomes: Structure, Function and Evolution

    Thoughts on Polypeptide Chain Elongation

    Twenty-Five Years of Research on Inhibitors of Protein Synthesis: Prospects for Future Developments in the Subject

    VI. Cell Biology and Neurobiology

    A Biochemist Looks at the Nervous System

    Brain Damage and Perinatal Biochemistry

    My Interrupted Association with Potassium

    A Personal Account of My Research on Collagen and Fibrosis

    VII. Science in the Time of Ochoa

    Reminiscences of Severo Ochoa from Our Oxford Days

    Highlights of a Friendship

    Discovery Made Easy

    Comments on the Productivity of Scientists

    Prebiological Chemistry and the Origin of Life: A Personal Account

    My Homage to Severo Ochoa

    Name Index

    Subject Index

Product details

  • No. of pages: 476
  • Language: English
  • Copyright: © Pergamon 1976
  • Published: January 1, 1976
  • Imprint: Pergamon
  • eBook ISBN: 9781483136028

About the Editors

A. Kornberg

B. L. Horecker

L. Cornudella

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