Reflections on Biochemistry: In Honour of Severo Ochoa offers reflections on a wide range of topics relating to biochemistry, including energy metabolism, lipids and saccharides, regulation, nucleic acids and the genetic code, protein biosynthesis, and cell biology. The essays celebrate Severo Ochoa's outstanding contributions to biochemistry spanning nearly half a century. This book is comprised of 47 chapters and begins with a biography of Ochoa and his scientific work in the field of biochemistry, particularly his research on intermediary metabolism, RNA synthesis, and the genetic code. The discussion then turns to energy metabolism, photosynthesis, and fermentation, touching on topics such as the role of lactic acid in the development of biochemistry and the biosynthesis of cell components from acetate. The next section is devoted to lipids, saccharides, and cell walls and includes chapters that deal with biotin, sulfur biochemistry, and dipicolinic acid. Subsequent chapters explore hormonal regulation of adipose tissue lipolysis; the structural relationship between genes and enzymes; bacteriophages, colicins, and ribosomes; and cell biology and neurobiology. This monograph will be of interest to biochemists and students of biochemistry.
Biographical Introduction: Severo Ochoa and the Development of Biochemistry I. Energy Metabolism, Photosynthesis, Fermentation The Role of Lactic Acid in the Development of Biochemistry Origins of the Concept of Oxidative Phosphorylation: Retrospectives and Perspectives Reflections on the Evolutionary Transition from Prokaryotes to Eukaryotes A Pathway from Psychiatry to Cancer Bioenergetics: Past, Present and Future Enzymes Revisited Unraveling the Pentose Phosphate Pathway Reducing Power and the Regulation of Photosynthesis Studies on High-Energy Phosphate Bonds: From Biosynthetic to Mechanochemical Reactions Glutamate Fermentation and the Discovery of B12 Coenzymes Trailing the Propionic Acid Bacteria Biosynthesis of Cell Components from Acetate Lessons in Learning The Impact of the ATP-Generating Systems II. Lipids, Saccharides, Cell Walls On the Evolution of a Biosynthetic Pathway My Expeditions into Sulfur Biochemistry The Clostridium kluyveri-Acetyl-CoA Epoch Biotin Unmasked The Seven Veils of Dipicolinic Acid Enzymic Mechanisms Involved in the Synthesis of Yeast Cell Wall III. Regulation The Pasteur Effect in the Allosteric Era Comparative Aspects of Hormonal Regulation of Adipose Tissue Lipolysis Reflections on the Relevance of Biochemistry for the Understanding of Living Systems Formation and Cleavage of C—N Bonds in Arginine Biosynthesis and Urea Formation Molecular Ecology IV. Nucleic Acids and the Genetic Code For the Love of Enzymes From Enzyme Chemistry to Genetic Manipulation The Search for the Structural Relationship between Gene and Enzyme Synthesis in the Study of Nucleic Acids A Phage in New York Bacteriophage ø29 V. Protein Biosynthesis Protein Synthesis: Early Waves and Recent Ripples Ten Years in Protein Synthesis Bacteriophages, Colicins
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- © Pergamon 1976
- 1st January 1976
- eBook ISBN: