Receptors in the Human Nervous System is a synthesis of the results of receptor mapping by leaders in the field. In addition to a comprehensive discussion of the distribution and possible interactions of the receptors of different neuroactive substances, this book also contains an abundance of pictorial representations of receptor distributions. High-quality photographs of one receptor are often juxtaposed with photographs of the distribution of a different receptor or receptor subtype for the consideration of possible interactions between different systems. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides. The distribution of multiple types of serotonin receptors is given in detail, and the codistribution of receptors in the cortex is discussed. The book is directed toward researchers in the field of chemical neuroanatomy, as well as pharmacologists, neurophysiologists, and neuroscientists.
Contributors Preface Chapter 1 Perspectives on Receptor Autoradiography and Human Brain Text References Chapter 2 Benzodiazepine, GABA and Glutamate Receptors in Cerebral Cortex, Hippocampus, Basal Ganglia, and Cerebellum Introduction Methods Results Discussion Abbreviations References Chapter 3 Acetylcholine, Serotonin and ß Adrenoceptors Introduction Methodology Cholinergic Muscarinic Receptors Serotonin Receptors ß-Adrenergic Receptors Discussion Abbreviations References Chapter 4 Multiple Serotonin Receptors in the Human Brain Labeling of 5-HT Receptors in the Brain for Autoradiography Distribution of 5-HT Receptors in Human Brain Conclusion and Future Trends Abbreviations References Chapter 5 Distribution of Multiple Opioid Receptors in the Human Brain Introduction Technical Comments Mu Opioid Receptors Delta Opioid Receptors Kappa Opioid Receptors Conclusion Abbreviations References Chapter 6 Angiotensin II Receptors in the Human Central Nervous System Brain Renin-Angiotensin System Experimental Methods Distribution of Ang II Receptor Binding in the Human Brain Discussion Conclusion Abbreviations References Chapter 7 Angiotensin-Converting Enzyme in the Human Brain Angiotensin-Converting Enzyme in the Central Nervous System Methods Results Discussion Conclusion Abbreviations References Chapter 8 Codistribution of Receptors in the Human Cerebral Cortex Introduction Material and Method Receptor Codistribution in the Human Hippocampus Receptor Codistribution in the Human Primary Visual Cortex Receptor Codistribution in the Human Frontal Agranular Cortex Receptor Codistribution in the Human Medial Temporal Gyrus General Aspects of Receptor Codistributions in t
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- © Academic Press 1991
- 28th July 1991
- Academic Press
- eBook ISBN:
Professor George Paxinos, AO (BA, MA, PhD, DSc) completed his BA at The University of California at Berkeley, his PhD at McGill University, and spent a postdoctoral year at Yale University. He is the author of almost 50 books on the structure of the brain of humans and experimental animals, including The Rat Brain in Stereotaxic Coordinates, now in its 7th Edition, which is ranked by Thomson ISI as one of the 50 most cited items in the Web of Science. Dr. Paxinos paved the way for future neuroscience research by being the first to produce a three-dimensional (stereotaxic) framework for placement of electrodes and injections in the brain of experimental animals, which is now used as an international standard. He was a member of the first International Consortium for Brain Mapping, a UCLA based consortium that received the top ranking and was funded by the NIMH led Human Brain Project. Dr. Paxinos has been honored with more than nine distinguished awards throughout his years of research, including: The Warner Brown Memorial Prize (University of California at Berkeley, 1968), The Walter Burfitt Prize (1992), The Award for Excellence in Publishing in Medical Science (Assoc Amer Publishers, 1999), The Ramaciotti Medal for Excellence in Biomedical Research (2001), The Alexander von Humbolt Foundation Prize (Germany 2004), and more.
Neuroscience Research Australia and The University of New South Wales, Sydney, Australia