Quantitative Functional Brain Imaging with Positron Emission Tomography

1st Edition

Editors: Richard Carson Peter Herscovitch Margaret Daube-Witherspoon
Hardcover ISBN: 9780121613402
eBook ISBN: 9780080540115
Imprint: Academic Press
Published Date: 28th August 1998
Page Count: 503
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This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain.

Key Features

@introbul:Key Features @bul:* Authored by international authorities in PET

  • Provides the latest up-to-date techniques and applications
  • Covers all fundamental disciplines of PET in one volume
  • A comprehensive resource for students, clinicians, and new PET researchers


Researchers, academic clinicians, and students in neuroscience, neurology, neuropsychology, and biophysics.

Table of Contents

Data Acquisition and Quantification:

S.R. Cherry, A. Chatziioannou, Y. Shao, R.W> Silverman, K. Meadors, and M.E. Phelps, Brain Imaging in Small Animals with MicroPET.

W.W. Moses, P.R.G. Virador, S.E. Derenzo, R.H. Huesman, and T.F. Budinger, Design of a High-Resolution, High-Sensitivity PET Camera for Human Brains and Small Animals.

Y. Shao, R. Slates, K. Farahani, A. Bowery, M. Dahlbom, K. Meadors, R.W. Silverman, M. Sugita, and S.R. Cherry, The Road to Simultaneous PET/MR Images of the Brain.

D.L. Bailey, M.P. Miller, T.J. Spinks, P.M. Bloomfield, L. Livieratos, R.B. Banati, R. Myers, and T.J. Jones, Brain PET Studies with a High Sensitivity Fully 3D Tomograph.

V. Sossi, K.S. Morrison, T.R. Oakes, and T.J. Ruth, Emission-Transmission Realignment Using a Simultaneous Emission-Transmission Postinjection Scan.

P. Johannsen, S.B. Hansen, L. Stergaard, and A. Gjedde, Optimization of H215O Dose and Data Acquisition in 3D Activation Studies Using an ECAT EXACT HR-47 PET Camera and Voxel-by-Voxel t-statistic.

S.R. Meikle, J.C. Matthews, V.J. Cunningham, D.L. Bailey, T. Jones, and P. Price, Parametric Image Reconstruction Using Spectral Analysis of Rebinned 3D Projection Data.

R.H> Huesman, G.J. Klein, B.W. Reutter, and X. Teng, Multi-Slice PET Quantitation Using 3D Volumes-of-Interest.

C. Labbe, M. Koepp, J. Ashburner, T. Spinks, M. Richardson, J. Duncan, and V. Cunningham, Absolute PET Quantification with Correction for Partial Volume Effects within Cerebral Structures.

O.G. Rousset, Y. Ma, D.F. Wong, and A.C. Evans, Pixel- versus ROI-based Partial Volume Correction in PET.

F. Yokoi, O.G. Rousset, A.S. Dogan, S. Marenco, A.C. Evans, A.H. Gjedde, and D.F. Wong, The Impact of Partial Volume Correction on Ki


No. of pages:
© Academic Press 1998
Academic Press
eBook ISBN:
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About the Editor

Richard Carson

Affiliations and Expertise

National Institutes of Health, Bethesda, Maryland, U.S.A.

Peter Herscovitch

Affiliations and Expertise

National Institutes of Health, Bethesda, Maryland, U.S.A.

Margaret Daube-Witherspoon

Affiliations and Expertise

National Institutes of Health, Bethesda, Maryland, U.S.A.


"This work is a collection of articles from the top researchers throughout the world, unified by the editors from the PET Department of the National Institutes of Health... Research areas including radiochemistry, instrumentation, quantification, modeling, and image analysis are integrated to provide a much-needed reference to the multi-faceted field of functional PET brain imaging... This text serves as an excellent reference for the active brain PET scientist and initiates the budding PET researcher into the complexities of the field. The integration of multidisciplinary research articles from worldwide authorities provides a necessary forum for fostering advances in brain PET research. The inclusions of the BRAINPET97 discussions further invite the reader to join the crusade. Anyone interested in brain PET research needs to be familiar with this book's content." @source:--DOODY'S PUBLISHING REVIEWS