Pyridines: from lab to production

1st Edition

Print ISBN: 9780123852359
eBook ISBN: 9780123852366
Imprint: Academic Press
Published Date: 22nd January 2013
Page Count: 582
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Provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more.

Key Features

  • Reviews tried and tested practical methods to help the reader select the best method for their research
  • Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative
  • Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on


A reference book for organic and pharmaceutical chemists and for those interested in the synthesis and manufacture of pyridine and its derivatives including those working in the polymer and material sciences. It is also appropriate as a reference book for the practical classes on synthetic organic chemistry.

Table of Contents

Best Synthetic Methods

Other volumes in the Series



Chapter 1. Introduction

1 Introduction

2 Value Chains

3 Strategic Considerations – Ring Synthesis Vs Substituent Manipulation

4 Challenges and Needs


Chapter 2. Ring Synthesis

1 Introduction

2 By the Formation of One Bond

3 By the Formation of Two Bonds

4 By the Formation of Three Bonds

5 Formation of Four Bonds

6 Transformations from Other Rings

7 Formal Exchange of Ring Members

8 Aromatisation

9 From Larger Molecules


Chapter 3. Attachment at Ring Positions

1 Introduction

2 Halogen

3 Sulphur and Selenium

4 Silicon

5 Tin

6 Phosphorus

7 Oxygen

8 Boron

9 Nitrogen

10 Carbon

11 Lithium

12 Magnesium

13 Zinc

14 Conclusion


Chapter 4. Substituent Modifications

1 Introduction

2 Carbon-Linked Substituents (Pyr-C)

4.3 Nitrogen-Linked Substituents (Pyr-N)

4.4 Oxygen-Linked Substituents (Pyr-O)

4.5 Sulphur-Linked Substituents (Pyr-S)

4.6 Halogen Linked to Ring (Pyr-halogen)

4.7 Substituents on the Ring Nitrogen (PyrN+-X)


Chapter 5. Formation of Completely or Partially Reduced Pyridines and Quinolines

1 Introduction

2 Preparation of Piperidine and Substituted Piperidines

3 Preparation of Saturated Quinolines

4 Biologically Active Piperidine and Tetrahydroquinoline compounds


Chapter 6. Applications to Alkaloid Synthesis

1 Introduction

2 Alkaloid Synthesis

3 Summary


Chapter 7. Fluorinated Pyridines

1 Fluoropyridines

2 Trifluoromethylpyridines

3 Conclusions


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© Academic Press 2013
Academic Press
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"Editor Scriven…presents this comprehensive reference for academics and industrialists working in the synthesis of pyridine derivatives. Strategic considerations for economizing reagents are discussed in the introduction; in particular, the question of whether to install substituents before or after cyclization is highlighted."--Reference & Research Book News, October 2013