Pyrantel Parasiticide Therapy in Humans and Domestic Animals - 1st Edition - ISBN: 9780128014493, 9780128016923

Pyrantel Parasiticide Therapy in Humans and Domestic Animals

1st Edition

Editors: Alan Marchiondo
eBook ISBN: 9780128016923
Paperback ISBN: 9780128014493
Imprint: Academic Press
Published Date: 2nd June 2016
Page Count: 158
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Pyrantel Parasiticide Therapy in Humans and Domestic Animals presents a single source history and reference on the parasiticide activity and pharmacology of the tetrahydropyrimidines and their salts in humans and domestic animals, also collating evidence that resistance to pyrantel has developed in human and domestic animal nematodes.

Other books of this nature have been compiled historically for specific anthelmintic compounds, but none has been written to date for the pyrantel family of drugs. Pyrantel, a nicotinic receptor agonist, has been used in domestic animal and human medicine since the 1970’s to control two important nematode groups, the hookworms and the roundworms.

Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both domestic animals and the public for more than 45 years.

Key Features

  • Easy-to-use reference guide on the anthelmintic pyrantel for clinicians, parasitologists, and researchers in human and veterinary medicine
  • Addresses current issues of resistance, along with combination uses against anthelmintic resistant parasites
  • Presents useful, authoritative information (chemical, pharmaceutical, clinical, etc.) for the pyrantel family of compounds
  • Includes a discussion on pyrantel’s potential role in combination therapies
  • Provides cutting-edge material, and will be an evolving area of scientific discussion of treatment options in the future


Academic and industrial parasitologists: graduate students, faculty, teachers, and researchers.  Veterinarians: graduate students, faculty, teachers, researchers, and clinicians. Medical Doctors: graduate students, faculty, teachers, researchers, clinicians.  Pharmacologists, Medicinal Chemists, Toxicologists, Molecular Biologists, Cell Biologists, Public Health Workers, and Government Agencies.

Table of Contents

  • List of Contributors
  • Preface
  • Introduction
  • Chapter 1. Discovery and Chemistry of Pyrantel, Morantel and Oxantel
    • Abstract
    • 1.1 Introduction
    • 1.2 Discovery of Pyrantel, Morantel, and Oxantel
    • 1.3 Structure Activity Relationships
    • 1.4 Synthesis of Tetrahydropyrimidine Drugs
    • 1.5 Physicochemical Characteristics and Anthelmintic Activities
    • 1.6 Conclusion
    • References
  • Chapter 2. Pharmacology of Pyrantel
    • Abstract
    • 2.1 Introduction
    • 2.2 Pharmacology
    • 2.3 Mechanism of Action
    • 2.4 Resistance to Pyrantel and Morantel
    • References
  • Chapter 3. The Safety of Pyrantel, Oxantel, and Morantel
    • Abstract
    • 3.1 Introduction
    • 3.2 Pyrantel
    • 3.3 Oxantel
    • 3.4 Morantel
    • 3.5 Discussion
    • References
  • Chapter 4. Formulations and Clinical Uses of Pyrimidine Compounds in Domestic Animals
    • Abstract
    • 4.1 Introduction
    • 4.2 Formulations
    • 4.3 Clinical Uses of Pyrimidine Compounds in Domestic Animals
    • 4.4 Conclusion
    • References
  • Chapter 5. Pyrantel Parasiticide Therapy in Humans
    • Abstract
    • 5.1 Introduction
    • 5.2 Current Global Strategy to Control Human Soil-Transmitted Helminthiasis
    • 5.3 Therapeutic Efficacy of PYR Against Human Soil-Transmitted Helminthiasis
    • 5.4 Role of PYR as a Mass Administration Drug
    • 5.5 Anthelmintic Resistance
    • 5.6 Conclusions
    • References
  • Chapter 6. Potential Applications of Tetrahydropyrimidines to Address Unmet Needs
    • Abstract
    • 6.1 Expanded Label Claims in Equine Combinations—Tapeworm Activity
    • 6.2 Combination Applications Against Resistant Parasites—Equine
    • References
  • Index


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© Academic Press 2016
Academic Press
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About the Editor

Alan Marchiondo

Alan Marchiondo

Veterinary Parasitologist; 30 years in animal health industry experience; FrontlinePlus synergy patent declaration; Parasiticide Discovery - identified a new chemical class of anthelmintic, a flea and tick adulticide for pets, and a new arylpyrazole compound highly active against ectoparasites of food producing animals; Clinical Development – developed 10 domestic and 4 international parasiticide products; Electron Microscopy; Past-President – American Association of Veterinary Parasitologists.

Affiliations and Expertise

Retired Research Fellow, Zoetis (formerly Pfizer Animal Health), Kalamazoo, MI, USA

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