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Pulmonary Deposition and Retention of Inhaled Aerosols - 1st Edition - ISBN: 9781483256719, 9781483258522

Pulmonary Deposition and Retention of Inhaled Aerosols

1st Edition

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Authors: Theodore F. Hatch Paul Gross
Editor: George D. Clayton
eBook ISBN: 9781483258522
Imprint: Academic Press
Published Date: 1st January 1964
Page Count: 208
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Pulmonary Deposition and Retention of Inhaled Aerosols is concerned with the respiratory deposition and retention of inhaled aerosols, starting with initial intake and concluding with events that precede pathological tissue response, drawing equally upon both the physical and biological aspects of the subject. The book opens with an introductory chapter on the relationship between the dose of an inhaled aerosol and the kind and degree of response, and classification of particulate substances. This is followed by separate chapters on pulmonary deposition and retention of inhaled aerosols; the factors that influence disease risks associated with atmospheric exposure to aerosols; and measurement of aerosol composition and concentration. It is hoped that the book will help the specialists from both sides as well as technical and administrative personnel to acquire a common understanding of the important intermediate factors that operate between the outside dusty atmosphere and the internal tissue damage and disease—factors that may operate to make one exposure dangerous to life and another altogether innocuous.

Table of Contents




Chapter 1 Introduction

1. Dose-Response Relationship

2. Classification of Particulate Substances

Chapter 2 Anatomical and Physiological Factors in Respiratory Deposition of Aerosols

1. Anatomical Arrangement

2. Aerodynamics of Respiration

Chapter 3 Physical Factors in Respiratory Deposition of Aerosols

1. Formalized Arrangement of the Respiratory System and of Air Flow

2. Physics of Particle Deposition

3. Nasal Deposition

4. Limitations in Analyses

Chapter 4 Experimental Studies on Deposition of Inhaled Aerosols

1. Measurement of Total Respiratory Deposition

2. Measurement of Regional Deposition within the Respiratory System

3. Respiratory Deposition in Animals versus That in Man

Chapter 5 Pulmonary Clearance

1. Upper Respiratory Tract Clearance

2. Alveolar Clearance

Chapter 6 Experimental Studies on Pulmonary Clearance

1. Upper Respiratory Clearance

2. Clearance from the Pulmonary Air Spaces

3. Early Postexposure Clearance

4. Long-Term Clearance

5. Mobilization from Dust Deposits

6. Permanent Dust Deposits

7. Particle Transport to Lymph Nodes

8. Summary

Chapter 7 Disease Risk from Inhaled Aerosols

1. Pneumoconioses

2. Systemic Poisons

3. Radioactive Particulate Hazards

4. Allergic and Other Sensitivity Responses

5. Air-Borne Infection

6. Particulate Contaminants in Community Air Pollution

Chapter 8 Measurement of Respirable Aerosol Exposure

1. Measurement of Aerosol Composition and Concentration

2. Two-Stage versus Multistage Sampling

3. Method of Expressing Aerosol Concentration


Author Index

Subject Index


No. of pages:
© Academic Press 1964
1st January 1964
Academic Press
eBook ISBN:

About the Authors

Theodore F. Hatch

Paul Gross

About the Editor

George D. Clayton

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