Protides of the Biological Fluids
Proceedings of the Twenty-Ninth Colloquium, 1981
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Protides of the Biological Fluids: An International Review Series Devoted to Proteins and Related Studies, Volume 29: Membrane Proteins, Receptor Ligand Interactions, Monoclonal Antibodies, New Methods focuses on membrane proteins, receptor-ligand interactions, and monoclonal proteins as a reagent. The selection first offers information on H-Y and sex determination and aspects of the difficulties to purify membrane proteins. Topics include solubilization by acylation, influence of supporting media on the aggregation of proteins, solubilization with detergents and organic solvents, and membrane proteins - giant detergent molecules. The text then examines the application of group-specific reagents for hydrophobic labeling and crosslinking of membrane proteins and comparison of secreted and membrane-bound human immunoglobulins M and D. The publication tackles sialoglycoproteins (glycophorins) in the plasma membranes of different cells and their receptor functions and the structures and antigenic properties of human erythrocyte membrane sialoglycoproteins. Discussions focus on the primary structure of human erythrocyte glycophorins, molecular structure of the MN bloodgroup substance, and genetic variants of glycophorin A. The book also takes a look at the glycoproteins of the human syncytiotrophoblastic plasma membrane and structure and function of a membrane glycoprotein encoded in the adenovirus genome. The selection is a valuable reference for readers interested in membrane proteins, receptor ligand interactions, and monoclonal antibodies.
Table of Contents
Preface
Acknowledgments
The Tenth Arne Tiselius Memorial Lecture
H-Y Antigen and Sex Determination
Section A. Membrane Proteins
A.1. Pure Membrane Proteins
A.1.1. Purification Procedures
Some General Aspects of the Difficulties to Purify Membrane Proteins
New Application of Group-Specific Reagents for Hydrophobic Labeling and Crosslinking of Membrane Proteins
The Use of a Zwitterionic Detergent and a Monoclonal Antibody in Purification of Rat Liver 5'-Nucleotidase
A.1.2. Immunoglobulins
Human IgD, The Gene and the Protein
Structural Studies of Human IgD
Comparison of Secreted and Membrane-Bound Human Immunoglobulins M and D
A.1.3. Glycoproteins
The Sialoglycoproteins (Glycophorins) in the Plasma Membranes of Different Cells and Their Receptor Functions
Structures and Antigenic Properties of Human Erythrocyte Membrane Sialoglycoproteins
Cytoskeleton-Associated Surface Glycoproteins of Murine Lymphocytes
The Relationship Between Differentiation of Friend Erythroleukemia Cells and Synthesis of Plasma Membrane-Bound Glycoproteins
Variations in the Structure of Surface Glycoproteins Present in Different Lymphocyte Subpopulations
Enhanced Neuraminidase-Resistant Sialic Acid Content in the Surface Glycopeptides of Human Leukaemic Hairy Cells
Reconstitution of Liposomes Bearing Platelet Membrane Glycoproteins. A Functional Study with Von Willebrand Factor
Human Platelet Membrane Glycoproteins IIb and IIIa May Form Ca2+-Dependent Complexes
Glycoproteins of the Human Syncytiotrophoblastic Plasma Membrane
Characterization of α-Tissue Antigen (αTA), A Membrane Glycoprotein of Cancer Cells
The Structure and Function of a Membrane Glycoprotein Encoded in the Adenovirus Genome
Protein Micelles and Virosomes from the Surface Glycoproteins of Parainfluenza 3 Virus
A.1.4. Erythrocyte Membrane Proteins
Human Red Cell Membrane Acetylcholinesterase, A Model Enzyme for the Study of Protein-Amphiphile Interactions
Spectrin Free Vesicles Obtained from Human Erythrocytes Without ATP-Depletion
Acylation of Integral Erythrocyte Membrane Proteins Resulting in a Soluble Form of Band 3 Protein
Self-Association of Band 3 Protein from Erythrocyte Membranes in Solutions of a Nonionic Detergent, Ammonyx-LO
Interactions of the Isolated Spectrin Polypeptides (Bands 1 and 2) with Phospholipid Monolayers
Red Cell Membrane Changes in a Heinz Body Anaemia (Kale Anaemia)
Ozone-Induced Cross-Linking of Erythrocyte Membrane Proteins
A.1.5. Various Cell Membrane Proteins
Membrane Proteins of Murine T Cell Clones
Isolation and Characterization of Basal-Lateral and Luminal Plasma-Membranes (PM) from the Proximal Tubule of Human Kidney
Further Immunochemical Studies of Tissue Polypeptide Antigen (TPA)
Purification of Membrane 5'Nucleotidase Preparation and Properties of Anti-5'Nucleotidase Serum
Characterization of Four Chick Brain Synaptic Membrane Proteins
Isolation of a Membrane Antigen from Electric Organ of Torpedo Californica
Characterization of Some Antigens Associated with the Membrane of Hampster Tumor Cells
Non-Specific Binding of (-)3H-Dihydroalprenolol to Intact Human Lymphocytes and Lymphocyte Membranes
Characterization of (-) (3H) Dihydroalprenolol Binding Sites on Intact Human Peripheral Blood Lymphocytes
A.1.6. Bacterial Membrane Proteins
Structure and Function of a Pore-Forming Transmembrane Protein: High Resolution Studies of a Bacterial Porin
Evidence for Protein-Lipid Interactions in Membranes of Acholeplasma Laidlawii
Isolation of Surface Antigens from Schistosoma Mansoni Schistosomula
Crossed Immunoelectrophoretic Analysis of the Purple Membrane of Halobacterium Halobium
A.2. Cell Surface Antigens
A.2.1. Beta 2 Microglobulin
Beta-2-Microglobulin and its Association with Histocompatibility Antigens of the Mouse and Rabbit
Evolutionary Conservation of the Interaction Between ß2-Microglobulin and ß2-Microglobulin-Binding Molecules
Seminal Plasma Levels of Beta2-Microglobulin and CEA-Like Protein in Infertility
Stimulation of Human Monocyte Chemotaxis by Anti-ß2-Microglobulin
Exchange of ß2-Microglobulin in Histocompatibility Antigens by its Human Analogue
Rat Serum Components with Affinity for Human ß2 Microglobulin
A.2.2. Blood Group Antigens
Human Blood Group M-, N-, T (Thomsen-Friedenreich)-, and Tn-Specific Lipidic Substances in Line-10 Hepatocarcinoma of Strain-2 Guinea Pigs
Further Evidence that Terminal ß-Galactopyranosyl Groups are Immunodeterminant in Blood Group N Specificity
A.2.3. Histocompatibility Antigens
Biosynthesis of HLA-A and -B Antigens
Biochemical Characterisation of Leukaemia-Associated Cell Surface Antigens
Influence of Selective Absence of H-2KK on Gross Virus Leukaemias In Vitro and the Implications for In Vivo Surveillance of Leukaemia
Primary Structural Analyses of Murine Major Histocompatibility Antigens
Characterization of DLA SD Antigens Using Immunochemical Techniques
Neuron-Specific Markers: A Critical Appraisal
Variations in the Antigenic Architecture of the Acholeplasma Laidlawii Cell Membrane
Interspecies Crossreactivities of Antisera Directed Against (Na,K)-ATPase Subunits from Bufo Marinus
A.3. Membrane Function
A.3.1. Transport Function
Transport of Proteins into Mitochondria
The Stereospecific D-Glucose Transport Activity of Cholate Extracts from Human Erythrocyte Membranes. Effects of Cholate, EDTA and Dithioerythritol
Side-Specific Transfer of Membrane-Bound Phospholipase A2 to Other Membranes by Fusion
Bile Acid Transport in Distal Ileum
The Kinetics of Intramolecular Crosslinking of the Band 3 Protein by 4,4′-Diisothiocyanato Dihydrostilbene-2,2′,-Disulfonic Acid (H2DIDS)
The Effect of Arginine Specific Reagents on Anion Transport Across Red Blood Cells
Does Ternary Complex Formation Control the State of the Cation Barrier in the Resealed Human Red Blood Cell Ghost?
A.3.2. Cell Adhesion
Microfilaments and Fibronectin Fibers Involved in the Formation of Fibroblast's Focal Contacts
Cell Surface Glycoproteins and Fibronectin Mediated Cell Adhesion
The Actin Network in Human Granulocytes at Different Stages of Phagocytosis in Granulopathies
Expression of Fibronectin and Plasminogen Activator in Human Cell Hybrids
Role of Fibronectin Degradation Products on Cellular Transformation
A.3.3 Cell Growth
Possible Role of the Plasma Membrane in Regulating Cell Growth Behaviour
Infiltration of Lymphosarcoma Cells into hepatocyte Cultures: Inhibition by Univalent Antibodies Against Liver Plasma Membranes and Lymphosarcoma Cells
The Role of Components of the Outer Membrane of Gram-Negative Bacteria in the Serum-Bactericidal Effect
Receptor-Ligand Interaction Leading to Entry of Myxoviruses into Host Cells
A.3.4. Cell Ageing
Molecular Aging: A Termination Antigen Appears on Senescent Cells
K+ Fluxes During T Lymphocyte Activation in Human Aging
Age-Related Defect of Cytokine-Ca2+ -cGMP Mediated Transmembrane Signal in T Lymphocyte Activation
Supramolecular Assembly of Membrane Constituents During 'In Vitro' Aging of Human Erythrocytes
Masking of RCA I Binding Sites by Hyaluronic Acid in Foetal Liver Cells
Parallel Increase of 3-0-Methylglucose Uptake and Cytochalasin B Binding in Chick Fibroblasts During Embryo Development
Section B. Receptor Ligand Interactions
B.1. Structure Activity Relations
The Acetylcholine Receptor: An Allosteric Membrane Protein
Structure and Function of the Human Platelet Von Willebrand Factor Receptor
Studies on the Receptor Sites of the Monoclonal Anti-Pr and -Sa Cold Agglutinins
Relations Between Serum α1-Foetoprotein (AFP) and Uterine Cytosol Receptors in the Immature Rat: Importance of Fatty Acids Ligands
Specific Binding of the Apo and Holoforms of the Serum DBP to the 'Soluble' Part of Actin from Human Lymphocytes and Platelets
ACTH Effects on Steroidogenesis and Adrenal Protein Synthesis: Relation Structure-Function
Similarities of the Gaunine Nucleotide Binding Sites Responsible for Adenylate Cyclase Activation and Carbamylcholine Binding Inhibition, In Rat Heart Membranes
Studies on the Hydrophobic Anchor of the Pig Intestinal Intrinsic Factor Receptor
Receptor-Mediated Endocytosis of Glycosylated Derivatives of Bovine Serum Albumin: Targeting Based on Sugar Recognition
Structure-Activity-Relationships in the Steroidal 17ß - Carboxamide Series
Binding of Cathepsin B by Haptoglobin
B.2. Immunoglobulin Receptors
Regulation of the Immune Response by the Fc Portion of Immunoglobulin
Human T-Lymphocytes' Fc-Receptors with High Affinity for Monomeric IgG
Isolation of Fcγ Receptors Released by Human Lymphocytes
Cyanogen Bromide Fragments of Mouse IgG2a and IgG2b which Bind to their Fc Receptors on Mouse Macrophages
Anti-Receptor Antibodies: A Comparison in the Rat of the Plasma to Bile Transfer of Purified IgG, F(ab′)2 and Fab′ Antibodies Against Rat Secretory Component (SC)
Receptor-Mediated Endocytosis of Polymeric IgA by Cultured Rat Hepatocytes
A Neo-Antigen Present on Complex α2M, Related to the Receptor Recognition Site
Events Initiated by Soluble Immune Complex Interaction with Immunoglobulin Receptors on Macrophages
B.3. Complement Receptors
Molecular Weight Analysis of Human Complement (C3) Receptors Isolated by Immunoprecipitation
The Receptor Functions of Endogeneous C1q, A Subcomponent of the First Component of Complement, on Peritoneal Macrophages
Receptors for C3b, C3bi, C3d and ß1H on Lymphocytes and Phagocytic Cells
B.4. Transferrin and Heme Receptors
Evidence for Endocytosis of Iron Loaded Transferrin by Cultured Rat Embryo Fibroblasts
Transferrin Receptors in Transformation and Differentiation
Mediation of a Receptor Mechanism in the Uptake of Iron from Transferrin by the Hepatocyte
Iron Uptake by Chinese Hamster Fibroblasts from Human Transferrin
Receptor-Mediated Endocytosis of Heme-Hemopexin by Rat Hepatocytes
Spectral and Other Studies on the Intestinal Heme Receptor of the Pig
B.5. Neurochemical Receptors
Differentiation Between Stereospecific Binding Sites on a Dopamine Receptor Complex: Effects of Proteolytic Enzymes
Biochemical and Pharmacological Studies of Substance P Receptors
Neurotensin-Receptor Interactions: Binding and Pharmacological Studies; Biological Relevance; Structure-Activity Relationships
A Novel Triazolopyridazine, 3H-CL 218, 872 which Labels the Benzodiazepine Receptor in Rat Brain
Immunological Studies of ß Adrenergic Catecholamine Receptors: A Two-Way Approach
Asymmetry of Acetylcholinesterase and Acetylcholine Receptor in Intact Secretory Vesicles from Adrenal Medulla
Loss of ß2-Adrenoceptors After Haemophilus Influenzae Vaccination
Characterization of Adrenergic Binding in Canine Lung Tissue
B.6. Vasoactive Intestinal Polypeptides (VIP)
Heterogeneity of VIP-Secretin Receptors in Three Rat Tissues
Vasoactive Intestinal Peptide (VIP) Control of Cyclic AMP Accumulation in Digestive Epithelia: Involvement of Multiple Regulatory Processes
Effects of GTP on Vasopressin, and Angiotensin Binding to Rat Liver Membranes
Cholecystokinin in Brain and Hypophysis
Vasoactive Intestinal Polypeptide (VIP): Specific Receptors on Smooth Muscle Membranes from Porcine Uterus
Impaired Secretin-VIP Sensitivity of Adenylate Cyclase in the Heart of Congenitally Hypertensive (SHR) or Obese (fa/fa) Rats
B.7. Hormone Receptors
B.7.1. Insulin Receptors
Multiple Functions of Peptides: Insulin and Vasoactive Intestinal Polypeptide Bind to Receptors in Liver and Brain
The Complex Kinetics of Insulin Binding to Receptors on Isolated Pig Hepatocytes
In Vivo Studies by Gamma-Camera of 131I-Insulin Distribution and Metabolism in Rabbits
Immunohistochemical and Autoradiographic Visualization of Porcine and Human 125I-Insulin Hepatic Binding In Vivo
B.7.2. Alpha MSH
Variation of α-MSH Receptivity Between Malignant Melanocytes from Horizontal and Vertical Growth Phases in a Human Superficial Spreading Melanoma
125I-α-MSH Binding in Human Melanoma Cell Lines
DNA Replication and Production of Retroviral Markers in Human Melanoma Cultures Depends on Degree of Differentiation and on Hormonal Stimulation
Binding of Endogenous α-MSH to Malignant Melanocytes in Human Melanomas
Hormonal Screening in Patients Suffering Malignant Melanoma. A Preliminary Approach
B.7.3. Other Hormones
Antibodies Against TSH Receptor in Graves' Disease: Evaluation by Release of cAMP
Antibodies Against TSH Receptor in Graves' Disease: Relation Between cGMP/cAMP Release
Negative Controls of Dog Thyroid Adenylate Cyclase Cyclic AMP System
Rat Liver Glucocorticoid Receptor Purified in Presence of Molybdate
Induction of Prolactin Liver Receptors in the Male Rat
An Affinity Adsorbent for an Estrogen Binding Protein Rat α-Fetoprotein
B.8. Various Receptors
Receptors for Regulatory Peptides in Epithelial Gut Cancer
Receptors that Control Acid Secretion in the Isolated Cells from Mammalian Gastric Mucosa
Microbial Receptors on Human Kidney Epithelia, A Possible Clue in the Pathogenesis of Bacterial Interstitial Nephritis
Section C. Monoclonal Antibodies
C.1. Hybridoma Technology
Human-Mouse Hybridoma Cells Producing Antibodies
Production of Rat Monoclonal Antibodies with the LOU Rat Non Secreting IR983F Myeloma Cell Line
Anti-Pr, -Gd and Related Cold Agglutinins: Human Monoclonal Antibodies Against Neuraminyl Groups
Analysis of Carbohydrate Determinants on Membranes of Leukemic Leukocytes Using Naturally Occurring Monoclonal Human Antibodies (Cold Agglutinins)
A Study of Hybridoma Soft Agar Cloning
Evaluation of Alternative Screening and Selection Procedures in Hybridoma Technology
Comparison of Screening Techniques Related to the Production of Monoclonal Antibodies
A Semi-Automated Enzyme-Linked Immunosorbent Assay (ELISA) to Screen for Hybridoma Cultures Producing Antibody to Carcinoembryonic Antigen (CEA)
Selection of Myeloma Lines Suitable for Hybridoma
Individual Physical Properties of Mouse Monoclonal Antibodies
C.2. Definition of Lymphocytes Subsets
Re-Definition of Human T Cells by Monoclonal Antibodies
Biochemical Studies of Human T Cell Markers
Mouse Monoclonal Antibodies Defining Functional Human Lymphocyte Subsets
T-Cell Profile and Reactivity In Vitro During Immune Reconstitution Following Bone Marrow Transplantation
Interaction of Monoclonal Antibodies and Antigen-Specific T-Cell Factor in Regulation of an Immune Response
Microfluorometric Analysis of Five Monoclonal Antibodies Directed Against Mouse Thymocytes
Binding Characteristics of a Monoclonal Antibody Against Rabbit Thymocytes
Abnormal Helper/Suppressor T-Cell Distribution in Chronic Brucellosis in Humans
Monoclonal Antibodies Defining Rabbit Lymphocyte Subpopulations
The Use of Monoclonal Antibodies to Monitor T-Cell Sub-Populations After Human Cardiac Transplantation
Monoclonal Anti-B Cell Antibodies: Their Effect on Human Mixed Lymphocyte Reactions
Monoclonal Antibodies Against Human Thymocytes and T Lymphocytes
Monoclonal Antibodies Against Rat Thymocytes
C.3. Determination of Histocompatibility Antigens
Monoclonal Antibodies Against Human MHC Products
Biochemical Analysis of Human HLA-DR Molecules
Functional Analysis of Human Ia Subsets
Reactivity of Monoclonal Anti-HLA Antibodies with Blood Platelets
Subsets of Human D Locus Products Identified by a Series of Monoclonal Antibodies
C.4. Viral and Bacterial Detection
Monoclonal Antibodies Detecting Epstein-Barr Virus Strain and Group Specific Antigenic Determinants
Monoclonal Antibody Against EBV-Associated Transformation Antigen Detected In Vitro and In Vivo
Production of Monoclonal Antibodies Against Poliomyelitis and Rabies Viruses
A Set of Monoclonal Antibodies to Streptococcal Group Polysaccharide Antigens
Hybridoma Antibody Mediated Activation of ß-Galactosidases from Genetically Defective E. Coli
Characterization of Monoclonal Antibodies to Subunit A of Cholera Toxin
Production of Monoclonal Antibodies Against Mycoplasma Hyorhinis as a Secondary Effect of Immunisation of Mice with Cultured Cell Lines
C.5. Detection of Proteins
Monoclonal Antibodies to the Human Leukocyte Interferons and Their Use for Interferon Purification and a Quantitative Interferon Assay
Radioimmunoassay (RIA) of Post-Gamma Globulin Using a Monoclonal Antibody
Localization of Collagen Type IV in Basement Membranes by Monoclonal Antibodies
Study of α1 Microglobulin (HC Protein) with Monoclonal Antibodies
Anti-Idiotypic Monoclonal Antibodies Against Myasthenie Antibodies
Quantitation of IgGkappa and IgGlambda in Normal and Pathological Sera
Use of Monoclonal Antibodies in the Characterisation of Immunoglobulin Classes and Subclasses in Animal Species
Monoclonal Antibodies Directed Against a Torpedo Electric Organ Membrane Antigen
C.6. Identification of Lipids
Monoclonal Antibodies Against Membrane Glycolipids of an Anti-Streptococcal Group A B-Cell Hybridoma
Monoclonal Antibody Secreting Mouse Hybridoma Clones Express Different Sets of Membrane Glycosphingolipids in Different Antigenic Systems
Glycosphingolipid Patterns of Established Human Hematopoietic Cell Lines
Monoclonal Antibodies to Tumor-Associated Glycolipids: Preparation and Application for Suppression of Tumor Growth
Monoclonal Antibodies Against Human Milkfat Globule Membranes Detecting Differentiation Antigens of the Mammary Gland
C.7. Determination of Hormones
Monoclonal Antibodies in Clinical Diagnosis — Reagents for Detecting Hormones and Immunoglobulins
Production of Monoclonal Antibodies to Steroid Hormones
Monoclonal Antibodies Against Growth Hormone: Effects on the Hormone Interaction with Specific Cell Surface Receptors
Monoclonal Antibodies Against Human Growth Hormone
Characteristics of Monoclonal Antibodies Against Human Chorionic Gonadotrophin (HCG)
Sensitive and Specific RIA for Human Chorionic Gonadotropin (hCG) Using Monoclonal Antibodies
The Use of Monoclonal Antibodies Against Prolactin (Prl) in a Solid Phase Enzyme-Immunoassay (EIA)
Mouse Monoclonal Antibodies Against Human Prolactine
Monoclonal Antibodies to Human Prolactin and Chorionic Somatomammotropin
Monoclonal Thyroglobulin-Autoantibodies as a Tool to Study Autoimmunity
C.8. Determination of Enzymes
Monoclonal Antibodies Against Two Antigens of Clinical Interest
Monoclonal Antibodies Against Human Acid α-Glucosidase
High-Affinity Monoclonal Autoantibody Used as a Reagent in a RIA for Human Creatine Kinase BB
C.9. Detection of Cancer Antigens
Five Melanoma-Associated Antigens Identified by Monoclonal Antibodies
Antigen Expression and Immune Lysis of Human Melanoma Cells: Analysis with Monoclonal Antibodies
Reactions of Monoclonal Antibodies Against Human Melanoma with Different Tissues and Cell Lines
Molecular Heterogeneity of a High Molecular Weight Human Melanoma Associated Antigen (MAA) Detected by Monoclonal Antibodies
A Monoclonal Antibody Defining a Burkitt Lymphoma Associated Antigen
Preparation and Characterization of Monoclonal Antibodies Against Antigens of Human Renal Adenocarcinoma
Monoclonal Antibodies Against Carcinoembryonic Antigen (CEA)
Characterisation of Monoclonal Antibodies to Carcinoembryonic Antigen by Antibody Overlay of Polyacrylamide Slab Gels
C.10. Drug Targeting
Phase I Trials of Murine Monoclonal Antibodies to Tumor Associated Antigens: Preliminary Observations
The Potential Use of Monoclonal Antibodies in Drug Targeting
Specific Killing of Human and Mouse Tumor Cells by Immunotoxins
Drug Targeting with Monoclonal Antibodies
Analysis of Human Haemopoietic Precursor Cell Antigens Using Astatine Labelled Monoclonal Antibodies
Section D. New Methods
The IGS (Immuno Gold Staining) Method Used with Monoclonal Antibodies
Enumeration of T Lymphocytes and their Subclasses in Peripheral Blood by Immunogold Staining
Chromatofocusing: A New High Resolution Method for Protein Fractionation
The Multiwire Proportional Counter for the Study of Ligand-Binding of Serum Proteins
Identification of Specific Antigens or Antibodies After Electrophoretic Transfer. Application to Measles Virus
Author Index
Subject Index
Product details
- No. of pages: 1010
- Language: English
- Copyright: © Pergamon 1982
- Published: January 1, 1982
- Imprint: Pergamon
- eBook ISBN: 9781483190327
About the Editor
H. Peeters
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