Protides of the Biological Fluids

Preface

Acknowledgments

The Ninth Arne Tiselius Memorial Lecture

Plasma Cell Tumors of Man and Mouse

Section A. Evolution of Proteins

A.l. Immunoglobulins

Evolutionary Studies of Immunoglobulin Protein and Nucleic Acid Sequences

Structure, Function, and Evolution of Human Immunoglobulins

Early Evolution of the Antibody Domain

Rabbit Antibody VL-Region Amino Acid Sequences Identification of J-Segments, an a Gene Interaction Model

Characterization of a Reptilian Macro-globulin Antibody

A.2. Fibrinogen

The Evolution of Vertebrate Fibrinogen

Fibrinogen Evolution: Intra- and Inter-species Comparisons

Human Fibrinogen: Sequence, Sulfur Bridges, Glycosylation and Some Structural Variants

A.3. Heme Proteins

Mode, Tempo, and Role of Natural Selection in the Evolution of Heme Proteins

On the Evolution of Bacterial Cytochromes C

Cytochromes C of Two Different Sequence Classes in Agrobacterium Tumefaciens

Partial Amino Acid Sequence of Pig heart Left Ventricular Myosin Light Chain L27

Caiman Crocodylus Hemoglobin—Structure and Activity

A.4. Metal Binding Protein

Internal Duplication in the Structure of Human Ceruloplasmin

The Relationship of the Small Blue Proteins with the Copper-Containing Oxidases

Comparative Studies of Ferritins

Calcium-binding Proteins: From Diversification of Structure to Diversification of Function

A.5. Proteases

Evolution of Haptoglobin and the Serine Proteases

Partial Sequence Comparison Between Human, Bovine and Porcine Plasminogen

Low Molecular Weight Protease

Comparison of the Amino Acid Composition of Tryptic Peptides Between Calamary and Rabbit Muscle Aldolase

Crayfish Trypsin: Missing Link Between Procaryote and Mammalian Serine proteases

Mouse NGF y-Subunit and Crab Collagenase: Two Serine Proteases of Unusual Function

A.6. Protease Inhibitors

Evolution of the Family of Serine Proteinase Inhibitors Homologous to Pancreatic Secretory Trypsin Inhibitor (Kazal)

Homology of α-Antitrypsin and Antithrombin-III Identification of Active Sites

A.7. Ribonuclease

The Molecular Evolution of Mammalian Pancreatic Ribonuclease

Ribonuclease Variation Within the Species

A.8. Various Proteins

Complete Primary Structure of the Hemagglutinin from Two Different Strains of Influenza A Type Virus

α-Lactalbumin: Studies of the Binding Site for Galactosyltransferase

Evolutionary Diversity in the Structure and Activity of Carbonic Anhydrase

Mutations Affecting the Structure of the Alcohol Dehydrogenase from Drosophila Melanogaster

Trends in the Molecular Evolution of α-Crystalline

Insulin-related Growth Factors

Pseudo-oligomer Theory to Explain Evolution of Soluble Proteins and their Binding to Receptors

On the Origin and Relation of Human Seminal Plasma Proteins to Plasma Proteins

Identification of Reptilian Complement Component C3

Comparative Molecular Aspects of the Chicken Major Histocompatibility Complex Coded Alloantigens

Section B. Molecular Biology of Blood Coagulation and Fibrinolysis

B.l. Contact Activation

The Role of Factor XII (Hageman Factor) in Blood Coagulation and a Partial Amino Acid Sequence of Human Factor XII and Its Fragments

Mechanism of Activation of Human Coagulation Factor XI and Plasma Prekallikrein

The Hageman Factor-Kallikrein System in Inflammatory Injury

Functions of the Kallikrein-Kinin System Outside the Clotting Cascade

The Ellagic Acid-Dependent Activation of Factor XI by Factor XII

Structural and Functional Aspects of Human High-molecular Weight (HMW) Kininogen

Recent Studies of Human High Molecular Weight Kininogen

Intrinsic Kallikrein- and Plasmin-Dependent Pathways of Activation of the Renin-angiotensin System in Plasma

Dextran Sulfate Induced Activation of Prekallikrein in Normal Human Plasma

Efficacy of Combined Treatment of Factor IX-Complex (PPSB) with ß-Propiolactone (ß-PL) and Ultraviolet (UV) Irradiation

The Intrinsic and Extrinsic Activation of Factor IX

B.2. Extrinsic System

The Tissue Factor Pathway of Coagulation: A Preliminary Kinetic Model

Tissue Thromboplastin—Molecular and Cellular Biology

Factor VII Activation in Plasma in the Presence of Activated Platelets

B.3. Prothrombin

The Carboxylation of Prothrombin Precursors in a Bovine Liver Cell-free System

Properties of the Vitamin K-Dependent Carboxylase

X-Ray Studies of Fragment 1 of Bovine Prothrombin

High Resolution Nuclear Magnetic Resonance Spectroscopy of Bovine Prothrombin Fragments

On the Role of Phospholipids in the Reaction Mechanism of Blood Coagulation

The Platelet Release Reaction and the Activation of Prothrombin

Dynamic Interaction of Prothrombin and Fragment I with Phospholipid Mono-layers

Effect of Anticoagulant Phospholipase A2 on Prothrombin Activation

Prothrombin and Stored Oxalated Plasma

B.4. Factor VIII

The Properties of Human Factor VIII Procoagulant Protein

Anomalous Behavior of Factor VHI-Von Willebrand Factor Complex as a Substrate for Serine Proteases

Chemical Composition of Factor VIII

Binding to Gold Granules Enhances Ristocetin Cofactor Activity of Low Molecular Weight Factor VIII

B.5. Fibrinogen and Fibrin

Paracrystalline Structure of Native Human Fibrinogen

Synthetic Peptide Probes and the Location of Fibrin Polymerization Sites

Structure of Fibrin Oriented in Strong Magnetic Fields

Calcium and the Structure of Fibrin(ogen) Fragments D

A Light Scattering Study of the Kinetics of Fibrin Polymerization

Fibrin/Fibrinogen Degradation Products (FDP) Analysis Using Laser Nephelometry

Fibrinogen—Coaguable or Inhibitor—by Treatment with ß-Propiolactone

B.6. Inhibitor of the Clotting System

A Human Inhibitor of Hageman Factor Acting as a Fibrinolytic Inhibitor

Anticoagulant Action of Human Protein C

Discrepancies Between Antigen Concentrations and Functional Activities of Plasma Protease Inhibitors

Characterization of Antithrombin III Deficiency in a Japanese Family

Antithrombin III Microheterogeneity Demonstrated by Agarose Isoelectric Focusing

Proteinase Inhibitors, Proteinases, Pro-Arylamidase in Fertilized and Unfertilized Eggs of Salmonids

B.7. Fibrinolytic System

Regulation and Control of Fibrinolysis

Fibrin-binding of Native Fragments of Known Primary Structure from Human plasminogen

Investigations on the Identification and Localization of Lysine Binding Sites of Human Plasminogen

Plasminogen Proactivators and Activators in Human Plasma: Factor XII-Dependent Fibrinolysis

On the Reaction Between Plasmin and α2-Antiplasmin

A Novel Method for the Preparation of Plasmin enabling the Study of Glu-Plasmin and its Role in Fibrinolysis

Human Tissue Plasminogen Activator and its Occurrence in Blood

The Effect of Fibrin on the Activity of Purified Human Vascular Plasminogen Activator

Inhibition of Plasmin or Plasmin-Streptokinase Complex by Aprotinin or a2-Antiplasmin

Maintenance of the Aprotinin-Binding Domain in Plasmin-Derived Light Chain as Shown by Affinity Chromatography

Comparison of Fibrinolytic and Amidolytic Measurements of Urokinase Activity in Urine

Relationship Between Activity Losses and the Conversion of High to Low Molecular Weight Urokinase

Effect of Dextran Sulphate on the S-2251 Splitting Activity of Human Plasma

Clotting and Other Plasma Factors in Septicemia: Inhibition of Degradation by an Exogenous Protease Inhibitor from Soybeans (Type: Bowman-Birk)

Unusual Kinetic Behavior of Plasmin (Fibrinolysin) Digestion of Fibrin and N-Carbobenzoxy-Tyrosine-Nitrophenyl-Ester

Fibrinolysis in Human Plasma

Section C. Hybridomas and Monoclonal Antibodies

C.l. Production of Monoclonal Antibodies

Secretion of Human Immunoglobulins in Man-Mouse Hybridomas: Correlation with ß2-Microglobulin and Chromosome 15

Immunoglobulin M Mutants

Enhancement of the Growth of Hybridomas by Human Endothelial Culture Supernatant (HECS)

Murine Cytolytic T-Lymphocyte Hybrids

T Cell Hybrids Producing Antigen Specific Factors

Production of Anti-Streptococcal Group A Antibodies by Hybridization Following In Vitro Immunization

HLA Antigens Temperature Dependent Elution from Specific Monoclonal Antibody Columns

Binding Kinetics of Monoclonal Antibodies to Cell Surface Antigens

Competition and Affinity Assay of Monoclonal Antibodies Against Human Growth Hormone

Detection of Monoclonal Antibodies Against Cell Surface Antigens Using Immunoperoxidase Procedures

Attachment of Lymphoid Cells to Glutaraldehyde Activated Plastic Cups: A Convenient Means for Quantitative Estimation of Cytoplasmic and Membrane Ig

Purification of IgE Heavy Chain mRNA from a Monoclonal Mouse Hybridoma

C.2. Monoclonal Antibody Conformation

Modification of Protein Conformation Induced by Monoclonal Antibodies: The ß Galactosidase Model

Structural Analysis of Hybridoma Derived Anti-p-Azobenzene-Arsonate (ABA) Antibodies

C.3. Monoclonal Antibodies and Cancer

Conjugates Between a Toxin Subunit and Monoclonal Antibodies (Immunotoxins) with High Specific Cytotoxicity

Monoclonal Antibodies to Three Tumor Markers: Human Chorionic Gonadotropin (hCG), Prostatic Acid Phosphatase (PAP) and Carcinoembryonic Antigen (CEA)

Demonstration of Human Melanoma Associated Antigen(s) by Monoclonal Antibodies

Use of Monoclonal Anti-CEA Antibodies in Immunoadsorbent Columns and Solid Phase Radioimmunoassay

Monoclonal Antibodies Against Carcinoembryonic Antigen (CEA)

Standardization of Monoclonal Antibodies for Clinical Studies in Leukemia/Lymphoma

C.4. Monoclonal Antibodies Against Cells and Lymphocytes

Antigen-Specific Suppressor Factor from a T-Hybrid Line and its ß Cell Acceptor

Mouse Monoclonal Antibodies Raised Against Human T Lymphocytes and Melanoma Cells

Monoclonal Antibody Specific for Normal and Neoplastic Human T Cells

Normal Values of Human Lymphocyte Subsets Defined by Monoclonal Antibodies

T Cell Hybridomas Mediating Specific Helper Cell and Cytotoxic Cell Activities

Inhibition of Mixed Lymphocyte Reaction by a Monoclonal Antibody Specific for a Rat T Cell Subset

Monoclonal Antibodies to Cell Surface Antigens on Cells of the Mouse Lymphoid System. Histophysiological Applications

C.5. Monoclonal Antibodies Against Molecules

The Repertoire of Anti-Influenza Antibodies

The Silent Repertoire: Antibodies Produced in Mice Suppressed for a Dominant Idiotype

Monoclonal Anti-Idiotypes as a Probe for the Analysis of the Diversity of Anti-Phosphorylcholine Antibodies

Characterization of a Syngenic Monoclonal Anti-Idiotypic Antibody to a Monoclonal Anti-Beef APO-Cytochrome c Antibody Obtained by Somatic Cell Fusion

Antigenic Variation of H-2 Molecules

Fine Antigenic Specificity of RNA-Binding Monoclonal Antibody from Autoimmune NZB/NZW Mouse

Production of Monoclonal Antibodies Against HLA-DR Antigens and the Human Plasma Plasminogen-Activator

Subsets of Human la-like Molecules Defined by Monoclonal Antibodies

Serological and Functional Characterization of Monoclonal Antibodies to Guinea Pig la-Antigens

Monoclonal Antibodies as Tools for the Study of Idiotype-Antiidiotype Interactions Along the Anti-Levan Immunization Chain

Monoclonal Antibodies to Human IgG; Finding of a Hybridoma Producing two Classes of Immunoglobulin (IgM and IgG) with Specificity for the same Antigen

Subject Index