Protides of the Biological Fluids

Protides of the Biological Fluids

Proceedings of the Twenty-Eighth Colloquium, 1980

1st Edition - January 1, 1980

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  • Editor: H. Peeters
  • eBook ISBN: 9781483189840

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Protides of the Biological Fluids covers the proceedings of the 28th Meeting on Protides of the Biological Fluids held in 1980. This book mainly focuses on the evolution of proteins; the molecular biology of blood coagulation and fibrinolysis; and the hybridomas. In studying the evolution of proteins, this text looks into the evolutionary studies of immunoglobulin protein and nucleic acid sequences, fibrinogen, proteases, and other proteins. This book then explains molecular biology of blood coagulation and fibrinolysis by explaining the Hageman factor, kallikrein–kinin system, human high molecular weight, and other biological processes involved. The hybridomas and monoclonal antibodies are also tackled by specifically discussing the production of monoclonal antibodies; monoclonal antibody conformation; and monoclonal antibodies against molecules. This publication will be invaluable to students, practitioners, and researchers in the field of biology and physiology who are interested in studying protides.

Table of Contents

  • Preface


    The Ninth Arne Tiselius Memorial Lecture

    Plasma Cell Tumors of Man and Mouse

    Section A. Evolution of Proteins

    A.l. Immunoglobulins

    Evolutionary Studies of Immunoglobulin Protein and Nucleic Acid Sequences

    Structure, Function, and Evolution of Human Immunoglobulins

    Early Evolution of the Antibody Domain

    Rabbit Antibody VL-Region Amino Acid Sequences Identification of J-Segments, an a Gene Interaction Model

    Characterization of a Reptilian Macro-globulin Antibody

    A.2. Fibrinogen

    The Evolution of Vertebrate Fibrinogen

    Fibrinogen Evolution: Intra- and Inter-species Comparisons

    Human Fibrinogen: Sequence, Sulfur Bridges, Glycosylation and Some Structural Variants

    A.3. Heme Proteins

    Mode, Tempo, and Role of Natural Selection in the Evolution of Heme Proteins

    On the Evolution of Bacterial Cytochromes C

    Cytochromes C of Two Different Sequence Classes in Agrobacterium Tumefaciens

    Partial Amino Acid Sequence of Pig heart Left Ventricular Myosin Light Chain L27

    Caiman Crocodylus Hemoglobin—Structure and Activity

    A.4. Metal Binding Protein

    Internal Duplication in the Structure of Human Ceruloplasmin

    The Relationship of the Small Blue Proteins with the Copper-Containing Oxidases

    Comparative Studies of Ferritins

    Calcium-binding Proteins: From Diversification of Structure to Diversification of Function

    A.5. Proteases

    Evolution of Haptoglobin and the Serine Proteases

    Partial Sequence Comparison Between Human, Bovine and Porcine Plasminogen

    Low Molecular Weight Protease

    Comparison of the Amino Acid Composition of Tryptic Peptides Between Calamary and Rabbit Muscle Aldolase

    Crayfish Trypsin: Missing Link Between Procaryote and Mammalian Serine proteases

    Mouse NGF y-Subunit and Crab Collagenase: Two Serine Proteases of Unusual Function

    A.6. Protease Inhibitors

    Evolution of the Family of Serine Proteinase Inhibitors Homologous to Pancreatic Secretory Trypsin Inhibitor (Kazal)

    Homology of α-Antitrypsin and Antithrombin-III Identification of Active Sites

    A.7. Ribonuclease

    The Molecular Evolution of Mammalian Pancreatic Ribonuclease

    Ribonuclease Variation Within the Species

    A.8. Various Proteins

    Complete Primary Structure of the Hemagglutinin from Two Different Strains of Influenza A Type Virus

    α-Lactalbumin: Studies of the Binding Site for Galactosyltransferase

    Evolutionary Diversity in the Structure and Activity of Carbonic Anhydrase

    Mutations Affecting the Structure of the Alcohol Dehydrogenase from Drosophila Melanogaster

    Trends in the Molecular Evolution of α-Crystalline

    Insulin-related Growth Factors

    Pseudo-oligomer Theory to Explain Evolution of Soluble Proteins and their Binding to Receptors

    On the Origin and Relation of Human Seminal Plasma Proteins to Plasma Proteins

    Identification of Reptilian Complement Component C3

    Comparative Molecular Aspects of the Chicken Major Histocompatibility Complex Coded Alloantigens

    Section B. Molecular Biology of Blood Coagulation and Fibrinolysis

    B.l. Contact Activation

    The Role of Factor XII (Hageman Factor) in Blood Coagulation and a Partial Amino Acid Sequence of Human Factor XII and Its Fragments

    Mechanism of Activation of Human Coagulation Factor XI and Plasma Prekallikrein

    The Hageman Factor-Kallikrein System in Inflammatory Injury

    Functions of the Kallikrein-Kinin System Outside the Clotting Cascade

    The Ellagic Acid-Dependent Activation of Factor XI by Factor XII

    Structural and Functional Aspects of Human High-molecular Weight (HMW) Kininogen

    Recent Studies of Human High Molecular Weight Kininogen

    Intrinsic Kallikrein- and Plasmin-Dependent Pathways of Activation of the Renin-angiotensin System in Plasma

    Dextran Sulfate Induced Activation of Prekallikrein in Normal Human Plasma

    Efficacy of Combined Treatment of Factor IX-Complex (PPSB) with ß-Propiolactone (ß-PL) and Ultraviolet (UV) Irradiation

    The Intrinsic and Extrinsic Activation of Factor IX

    B.2. Extrinsic System

    The Tissue Factor Pathway of Coagulation: A Preliminary Kinetic Model

    Tissue Thromboplastin—Molecular and Cellular Biology

    Factor VII Activation in Plasma in the Presence of Activated Platelets

    B.3. Prothrombin

    The Carboxylation of Prothrombin Precursors in a Bovine Liver Cell-free System

    Properties of the Vitamin K-Dependent Carboxylase

    X-Ray Studies of Fragment 1 of Bovine Prothrombin

    High Resolution Nuclear Magnetic Resonance Spectroscopy of Bovine Prothrombin Fragments

    On the Role of Phospholipids in the Reaction Mechanism of Blood Coagulation

    The Platelet Release Reaction and the Activation of Prothrombin

    Dynamic Interaction of Prothrombin and Fragment I with Phospholipid Mono-layers

    Effect of Anticoagulant Phospholipase A2 on Prothrombin Activation

    Prothrombin and Stored Oxalated Plasma

    B.4. Factor VIII

    The Properties of Human Factor VIII Procoagulant Protein

    Anomalous Behavior of Factor VHI-Von Willebrand Factor Complex as a Substrate for Serine Proteases

    Chemical Composition of Factor VIII

    Binding to Gold Granules Enhances Ristocetin Cofactor Activity of Low Molecular Weight Factor VIII

    B.5. Fibrinogen and Fibrin

    Paracrystalline Structure of Native Human Fibrinogen

    Synthetic Peptide Probes and the Location of Fibrin Polymerization Sites

    Structure of Fibrin Oriented in Strong Magnetic Fields

    Calcium and the Structure of Fibrin(ogen) Fragments D

    A Light Scattering Study of the Kinetics of Fibrin Polymerization

    Fibrin/Fibrinogen Degradation Products (FDP) Analysis Using Laser Nephelometry

    Fibrinogen—Coaguable or Inhibitor—by Treatment with ß-Propiolactone

    B.6. Inhibitor of the Clotting System

    A Human Inhibitor of Hageman Factor Acting as a Fibrinolytic Inhibitor

    Anticoagulant Action of Human Protein C

    Discrepancies Between Antigen Concentrations and Functional Activities of Plasma Protease Inhibitors

    Characterization of Antithrombin III Deficiency in a Japanese Family

    Antithrombin III Microheterogeneity Demonstrated by Agarose Isoelectric Focusing

    Proteinase Inhibitors, Proteinases, Pro-Arylamidase in Fertilized and Unfertilized Eggs of Salmonids

    B.7. Fibrinolytic System

    Regulation and Control of Fibrinolysis

    Fibrin-binding of Native Fragments of Known Primary Structure from Human plasminogen

    Investigations on the Identification and Localization of Lysine Binding Sites of Human Plasminogen

    Plasminogen Proactivators and Activators in Human Plasma: Factor XII-Dependent Fibrinolysis

    On the Reaction Between Plasmin and α2-Antiplasmin

    A Novel Method for the Preparation of Plasmin enabling the Study of Glu-Plasmin and its Role in Fibrinolysis

    Human Tissue Plasminogen Activator and its Occurrence in Blood

    The Effect of Fibrin on the Activity of Purified Human Vascular Plasminogen Activator

    Inhibition of Plasmin or Plasmin-Streptokinase Complex by Aprotinin or a2-Antiplasmin

    Maintenance of the Aprotinin-Binding Domain in Plasmin-Derived Light Chain as Shown by Affinity Chromatography

    Comparison of Fibrinolytic and Amidolytic Measurements of Urokinase Activity in Urine

    Relationship Between Activity Losses and the Conversion of High to Low Molecular Weight Urokinase

    Effect of Dextran Sulphate on the S-2251 Splitting Activity of Human Plasma

    Clotting and Other Plasma Factors in Septicemia: Inhibition of Degradation by an Exogenous Protease Inhibitor from Soybeans (Type: Bowman-Birk)

    Unusual Kinetic Behavior of Plasmin (Fibrinolysin) Digestion of Fibrin and N-Carbobenzoxy-Tyrosine-Nitrophenyl-Ester

    Fibrinolysis in Human Plasma

    Section C. Hybridomas and Monoclonal Antibodies

    C.l. Production of Monoclonal Antibodies

    Secretion of Human Immunoglobulins in Man-Mouse Hybridomas: Correlation with ß2-Microglobulin and Chromosome 15

    Immunoglobulin M Mutants

    Enhancement of the Growth of Hybridomas by Human Endothelial Culture Supernatant (HECS)

    Murine Cytolytic T-Lymphocyte Hybrids

    T Cell Hybrids Producing Antigen Specific Factors

    Production of Anti-Streptococcal Group A Antibodies by Hybridization Following In Vitro Immunization

    HLA Antigens Temperature Dependent Elution from Specific Monoclonal Antibody Columns

    Binding Kinetics of Monoclonal Antibodies to Cell Surface Antigens

    Competition and Affinity Assay of Monoclonal Antibodies Against Human Growth Hormone

    Detection of Monoclonal Antibodies Against Cell Surface Antigens Using Immunoperoxidase Procedures

    Attachment of Lymphoid Cells to Glutaraldehyde Activated Plastic Cups: A Convenient Means for Quantitative Estimation of Cytoplasmic and Membrane Ig

    Purification of IgE Heavy Chain mRNA from a Monoclonal Mouse Hybridoma

    C.2. Monoclonal Antibody Conformation

    Modification of Protein Conformation Induced by Monoclonal Antibodies: The ß Galactosidase Model

    Structural Analysis of Hybridoma Derived Anti-p-Azobenzene-Arsonate (ABA) Antibodies

    C.3. Monoclonal Antibodies and Cancer

    Conjugates Between a Toxin Subunit and Monoclonal Antibodies (Immunotoxins) with High Specific Cytotoxicity

    Monoclonal Antibodies to Three Tumor Markers: Human Chorionic Gonadotropin (hCG), Prostatic Acid Phosphatase (PAP) and Carcinoembryonic Antigen (CEA)

    Demonstration of Human Melanoma Associated Antigen(s) by Monoclonal Antibodies

    Use of Monoclonal Anti-CEA Antibodies in Immunoadsorbent Columns and Solid Phase Radioimmunoassay

    Monoclonal Antibodies Against Carcinoembryonic Antigen (CEA)

    Standardization of Monoclonal Antibodies for Clinical Studies in Leukemia/Lymphoma

    C.4. Monoclonal Antibodies Against Cells and Lymphocytes

    Antigen-Specific Suppressor Factor from a T-Hybrid Line and its ß Cell Acceptor

    Mouse Monoclonal Antibodies Raised Against Human T Lymphocytes and Melanoma Cells

    Monoclonal Antibody Specific for Normal and Neoplastic Human T Cells

    Normal Values of Human Lymphocyte Subsets Defined by Monoclonal Antibodies

    T Cell Hybridomas Mediating Specific Helper Cell and Cytotoxic Cell Activities

    Inhibition of Mixed Lymphocyte Reaction by a Monoclonal Antibody Specific for a Rat T Cell Subset

    Monoclonal Antibodies to Cell Surface Antigens on Cells of the Mouse Lymphoid System. Histophysiological Applications

    C.5. Monoclonal Antibodies Against Molecules

    The Repertoire of Anti-Influenza Antibodies

    The Silent Repertoire: Antibodies Produced in Mice Suppressed for a Dominant Idiotype

    Monoclonal Anti-Idiotypes as a Probe for the Analysis of the Diversity of Anti-Phosphorylcholine Antibodies

    Characterization of a Syngenic Monoclonal Anti-Idiotypic Antibody to a Monoclonal Anti-Beef APO-Cytochrome c Antibody Obtained by Somatic Cell Fusion

    Antigenic Variation of H-2 Molecules

    Fine Antigenic Specificity of RNA-Binding Monoclonal Antibody from Autoimmune NZB/NZW Mouse

    Production of Monoclonal Antibodies Against HLA-DR Antigens and the Human Plasma Plasminogen-Activator

    Subsets of Human la-like Molecules Defined by Monoclonal Antibodies

    Serological and Functional Characterization of Monoclonal Antibodies to Guinea Pig la-Antigens

    Monoclonal Antibodies as Tools for the Study of Idiotype-Antiidiotype Interactions Along the Anti-Levan Immunization Chain

    Monoclonal Antibodies to Human IgG; Finding of a Hybridoma Producing two Classes of Immunoglobulin (IgM and IgG) with Specificity for the same Antigen

    Subject Index

Product details

  • No. of pages: 638
  • Language: English
  • Copyright: © Pergamon 1980
  • Published: January 1, 1980
  • Imprint: Pergamon
  • eBook ISBN: 9781483189840

About the Editor

H. Peeters

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