Protides of the Biological Fluids

Protides of the Biological Fluids

Proceedings of the Twenty-Third Colloquium, Brugge, 1975

1st Edition - January 1, 1976

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  • Editor: H. Peeters
  • eBook ISBN: 9781483159034

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Description

Protides of the Biological Fluids contains the proceedings of the 23rd Colloquium on "Protides of the Biological Fluids" held in Brugge, Belgium in 1975. The discussions were organized around three themes: proteinase inhibitors, clinical evaluation of plasma protein patterns, and affinity chromatography. Comprised of 117 chapters, this volume begins with an overview of carcinofetal proteins, followed by an analysis of proteinase inhibition. The reader is then introduced to the mechanism and structure of human alpha-1-proteinase inhibitor; some properties of a complex between ?2-macroglobulin and brinase; and the interaction of proteinase inhibitors with blastocyst proteinases involved in implantation. Subsequent chapters deal with the thermodynamics and kinetics of the interaction of trypsin with trypsin inhibitors; purification and characterization of acid-stable proteinase inhibitors from human seminal plasma; and the possible role of protease inhibitors in cartilage metabolism. The book also explores the structure and function of animal proteinase inhibitors as well as techniques and methods used in clinical evaluation of plasma protein patterns. This monograph will be of interest to biologists and research workers in biology.

Table of Contents


  • Preface

    Acknowledgements

    The Fourth Arne Tiselius Memorial Lecture

    Carcinofetal Proteins

    Section A. Proteinase Inhibitors

    A1. Proteinase Inhibitor Interaction

    A1.1. Molecular Aspects and Quantitation

    Chemical Studies on Proteinase Inhibition

    Mechanism and Structure of Human Alpha-1-Proteinase Inhibitor

    Inhibition of Urokinase by Purified Human α1-Antitrypsin

    Interaction Between Alpha1-Antitrypsin and Alpha2-Macroglobulin in the Elimination of Proteolytic Enzymes

    Some Properties of a Complex Between α2-Macroglobulin and Brinase

    Kunitz Bovine Trypsin Inhibitor: Interaction with α-Chymotrypsin

    Kinetics of the Interaction of Virgin and Modified Bovine Trypsin Kallikrein Inhibitor (Kunitz) with β-Trypsin

    Interaction of Proteinase Inhibitors with Blastocyst Proteinases involved in Implantation

    Blocking of C1 Esterase Inhibitor by Cold Promoted Activation of Factor VII

    Direct Identification of Specific Protease Inhibitors in Mixtures by Modified Quantitative Immunoelectrophoresis

    Studies on the Inhibition of Renin by Radioimmunoassay

    A1.2. Kinetics and Thermodynamics

    Thermodynamics and Kinetics of the Interaction of Trypsin with Trypsin Inhibitors

    The Inhibition of Human and Bovine Trypsins and Chymotrypsins by the Inter-α-Inhibitor from Human Plasma

    Kinetic and Thermodynamic Studies of Human Alpha-1-Proteinase Inhibitor

    A2. Structure and Function of Human Proteinase Inhibitors

    A2.1. In Plasma

    Structure of α1-Antitrypsins

    α-1-Proteinase Inhibitor Deficiency Disease: A Probable Inborn Error of Carbohydrate Side Chain Synthesis

    New Data Concerning Inter-Alpha-Trypsin-Inhibitor

    The Role of Sialic Acid in Hepatic Uptake of Alpha1-Antitrypsin

    Preparative Separation of Various Bands of Alpha-1-Antitrypsin by Electrofocusing in Thin-layer Polyacrylamide Gel

    Circular Dichroism Studies on α-1-Proteinase Inhibitor

    Subunit Structure of Human Alpha-2-Macroglobulin. Its Relationships with its Biological Activity

    Comparative Study of Rat c^-Macroglobulin and Rat α2-Macroglobulin: Interaction with Trypsin and Chymotrypsin

    Primary Structure of Hirudin, A Thrombin-Specific Inhibitor

    The Partial Purification and Characterization of Inter-α-Antiplasmin from Human Serum

    A Low Molecular Weight Elastase Inhibitor from Human Serum

    A2.2. In the Reproductory System

    Acid-stable Proteinase Inhibitors from Human Seminal Plasma: Purification and Characterization

    Proteinase Inhibitors in Testicular and Epididymal Fluid

    An Acid-stable Proteinase Inhibitor in Human Cervical Mucus

    A2.3. In Pancreatic Tissue

    Human Pancreatic Secretory Trypsin Inhibitor, Amino Acid Sequence

    1H NMR Studies of the Dynamics of the Solution Conformation of the Basic Pancreatic Trypsin Inhibitor (BPTI)

    The Effect of Trypsin-Inhibitors on the Rat Exocrine Pancreas

    Comparative 1H NMR Studies of the Solution Conformation of the Cow Colostrum Trypsin Inhibitor (CTI), The Trypsin Inhibitor of Helix Pomatia (HPI) and the Basic Pancreatic Trypsin Inhibitor (BPTI)

    Isolation and Properties of an Aortic Elastase

    Measurement of the Proteinase Inhibitors of the Bovine Pancreas by Radio-Immunoassay

    A2.4. In Other Tissues

    Tissue Inhibitors are Cell Growth Regulators

    The Possible Role of Protease Inhibitors in Cartilage Metabolism

    The Isolation, Purification and Partial Characterization of Proteinase Inhibitors from Bovine Cartilage and Aorta

    Characterization of Proteinase-Inhibitor Complexes in the Purulent Secretions of Mucous Membranes as Complexes Between Leucocytic Elastase and Proteinase Inhibitors

    A3. Structure and Function of Animal Proteinase Inhibitors

    Evolution of Proteinase Inhibitors

    Electrophoretic Variants of Serum α1-Antitrypsin in Baboons

    Antitrypsin Polymorphism in Sub-Human Primates

    Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors

    About the Aminoacid Sequence of the Proteinase Inhibitors from Dog Submandibularis Glands

    Characterization and Inhibitory Properties of Snail Secretory Proteinase Inhibitors

    Interaction of Exopeptidases with Specific Proteins from Ascaris Lumbricoides

    Broad Specificity Proteinase Inhibitors from Sea Anemones

    Section B. Clinical Evaluation Of Plasma Protein Patterns

    B1. Techniques and Methods

    An Automated Approach to the Preparation of Plasma Protein Profiles

    Determination of Proteins by Laser Nephelometry

    Immunochemical Determination of Blood Proteins

    A New Radioimmunoassay of α-Fetoprotein and Carcinoembryonic Antigen

    B2. Interpretation

    Human Plasma Proteins Discovered During the Last Few Years and their possible Value for Clinical Diagnosis

    The Management of Specific Protein Data

    Routine Serum Protein Analysis: Trends, Facts and Fallacies

    The Use of Discriminant Function Analysis in Selecting Individual Proteins for Routine Clinical Investigation

    α2-Antithrombin Levels in Relation to Age and Sex

    The Serum Level of β2-Microglobulin (β2μ) - A Low Molecular Weight Protein

    B3. Pregnancy Levels

    Plasma Protein Profiles of Serum and Amniotic Fluid in Normal Pregnancy and Pre-Eclampsia

    α1-Fetoprotein in Pregnancy

    B4. Profiles Typical of a Disorder

    B4.1. Alpha-Antitrypsin System

    Purification of α1-Antitrypsin Ultilizing Thiol-Disulphide Interchange

    Prevalence of Pi Types Among Newborns of Different Ethnic Backgrounds

    The Alpha1-Antitrypsin Null Gene Frequency

    Pi MRouen Phenotype in a Pi-Subject

    A New Deficiency Allele of Alpha1-Antitrypsin: Pi MMalton

    Proteinase Inhibitors in Bronchial Secretions from Patients with Alpha-1-Antitrypsin Deficiency

    Alpha-1-Antitrypsin Deficiency and Adult Liver Disease

    High Serum Complement Component Levels in Patients with Alpha-1-Antitrypsin Deficiency

    B4.2. Immune Disorders

    Immunoglobulin Abnormalities in Primary Immunodeficiency Diseases

    Immune System Disorders in Man and in Experimental Models accompanied by the Production of Homogeneous Immunoglobulins—Paraproteins

    A New Case of IgE Myelomatosis

    Imbalances of K/λ Immunoglobulin Light Chain Ratios in Normal Individuals and in Immunodeficient Patients

    On the Idiotypic Determinants of Human Paraproteins: A Family Study

    B4.3. Liver and Renal Diseases

    Changes of the Dye-Binding Properties of Serum Proteins in Liver Diseases

    Plasma Protein Pattern in Hepatitis A and B

    Serum and Urinary Protein Analysis by SDS—PAA Electrophoresis Combined with Immunoprecipitation: Dimer Albumin in the Nephrotic Syndrome

    Behaviour of Prealbumin, Albumin, Cholinesterase and Normotest in Blood of Patients with Chronic Hepatitis and Postnecrotic Cirrhosis

    The Level of Acid Stable Protease Inhibitors in Plasma as an Indicator of Renal Function

    B4.4. Rheumatic Diseases

    Changes in Concentration and Synthesis Rates of Plasma Proteins During Experimental Arthritis

    Serum Protein Profiles in Rheumatoid Arthritis

    B5. Factors Regulating Protein Profiles

    The Definitive Role of Known Hormones in the Regulation of Net Biosynthesis of Five Acute Phase Plasma Proteins (APPP) by the Isolated Perfused Rat Liver: Corticosterone

    How is C-Reactive Protein (CRP) Synthesis Regulated? Studies in Isolated Perfused Rabbit Liver

    α2-Macroglobulin as an in vivo Tracer

    Protein Permeability of the Blood - CSF Barrier

    The Blood—CSF Barrier for IgG: A Semiological Estimation in Multiple Sclerosis

Product details

  • No. of pages: 718
  • Language: English
  • Copyright: © Pergamon 1976
  • Published: January 1, 1976
  • Imprint: Pergamon
  • eBook ISBN: 9781483159034

About the Editor

H. Peeters

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