Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions

Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions

1st Edition - April 30, 2021

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  • Editor: Gisa Gerold
  • eBook ISBN: 9780128230404
  • Hardcover ISBN: 9780128230428

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Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions, Volume 109 in the Advances in Virus Research series, highlights state-of-the art mass spectrometry techniques to elucidate the tight interplay of vertebrate viruses and their host cells. The volume includes chapters on Spatio-temporal resolution of host protein complexes during virus entry, Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis, Applications of Mass Spectrometry Imaging in Virus Research, Mapping surfaceome dynamics during viral infection, Characterization of proteolytic events in virus-host interactions, Dynamic protein network modulation upon viral infection, and much more.

Key Features

  • Discusses the latest methodological breakthroughs in mass spectrometry-based proteomics
  • Reviews how technology has advanced our knowledge on virus-host interactions
  • Provides future perspectives on proteomics research in virology


Researchers, students and academics in the field of virus research, or those in the field of protein biochemistry with an interest in viral infections

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Virus systems biology: Proteomics profiling of dynamic protein networks during infection
  • Abstract
  • 1: Host cell proteome modulation during viral infection
  • 2: Viral systems biology
  • 3: Proteomics methodologies to measure dynamic protein networks
  • 4: Conclusions
  • Acknowledgments
  • Chapter Two: Applications of mass spectrometry imaging in virus research
  • Abstract
  • 1: Introduction
  • 2: MALDI imaging
  • 3: DNA viruses
  • 4: RNA viruses
  • 5: Reverse transcribing viruses
  • 6: Conclusions
  • Acknowledgments
  • Chapter Three: Proximity labeling approaches to study protein complexes during virus infection
  • Abstract
  • 1: Introduction
  • 2: Methodology
  • 3: Cell biological applications of proximity labeling
  • 4: Proximity labeling to study host-pathogen interactions
  • 5: Future perspectives and limitations of the technology
  • Acknowledgments
  • Chapter Four: Elucidation of host-virus surfaceome interactions using spatial proteotyping
  • Abstract
  • 1: The surfaceome is the host's cellular interface enabling viral entry, immune evasion, and viral spread
  • 2: Mapping the surfaceome and its interaction network
  • 3: Deciphering virus binding and entry strategies to guide rational design of antiviral strategies
  • 4: Elucidation of virus-induced surfaceome dynamics
  • 5: The surfaceome and its role in viral spreading
  • 6: Perspective
  • Acknowledgments
  • Conflict of interest statement
  • CRediT authorship contribution statement
  • Chapter Five: Proteomics approaches for the identification of protease substrates during virus infection
  • Abstract
  • 1: Introduction
  • 2: Gel-based proteomics methods
  • 3: Gel-free proteomics methods
  • 4: Virus-host protein-protein interactions
  • 5: Conclusion and future perspectives
  • Acknowledgments
  • Chapter Six: Post-translational modification control of viral DNA sensors and innate immune signaling
  • Abstract
  • 1: Introduction
  • 2: Mass spectrometry-based proteomic characterization of PTMs
  • 3: DNA sensors are regulated by a combination of PTMs
  • 4: Virus-induced PTMs for dampening or evading the host innate immune response
  • 5: PTMs on DNA sensors affect disease progression and treatment
  • 6: Future perspectives
  • Acknowledgments
  • Chapter Seven: Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis
  • Abstract
  • 1: Introduction
  • 2: Proteomics approaches discussed in this chapter
  • 3: Contributions of proteomics toward the discovery of KSHV and EBV virion composition
  • 4: Contributions of proteomics toward elucidating virus-host PPIs
  • 5: Contributions of proteomics toward elucidating virus-virus PPIs
  • 6: Determination of the protein content of exosomes secreted from gammaherpesvirus-infected cells
  • 7: Clinical implementation of proteomics for the diagnosis and treatment of KSHV- and EBV-associated cancers
  • 8: Conclusions and future perspectives
  • Acknowledgments
  • Conflict of interest

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: April 30, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128230404
  • Hardcover ISBN: 9780128230428

About the Serial Volume Editor

Gisa Gerold

Gisa Gerold
Dr. Gisa Gerold accomplished her graduate research at the Max Planck Institute for Infection Biology, Berlin, Germany, under the supervision of Arturo Zychlinsky. She pursued her postdoctoral work in the laboratory of Virology and Infectious Diseases of Charles M. Rice at The Rockefeller University, New York, NY. Currently, she is a professor for Molecular and Clinical Infection Research at the Institute for Biochemistry at the University of Veterinary Medicine Hannover, Germany. She further holds a Guest Associate Professor position at the Department of Clinical Microbiology and the Wallenberg Center for Molecular Medicine at Umea University, Sweden. Her joint German and Swedish research team focuses on elucidating pathogenic RNA virus infection from a proteomics perspective. With a particular focus on emerging zoonotic viruses and their interplay with the host cell at the protein level, her goal is to unravel mechanisms of pathogenesis, host and tissue tropism determinants and key points of therapeutic intervention. By integrating proteomics techniques with cell biology, virology and big data science she strives to bridge the gap between virus and host genetics and a mechanistic understanding of virus infection in order to develop rapid response measures against newly emerging pathogens. Dr. Gerold received the Otto Hahn Medal of the Max Planck Society and the Robert Koch Society postdoctoral award in Virology. She is a member of the advisory board of the German Society for Virology (GfV).

Affiliations and Expertise

University of Veterinary Medicine Hannover, Germany Umeå University, Sweden University of Veterinary Medicine Hannover, Department of Biochemistry & Research Center for Emerging Infections and Zoonoses (RIZ), Hannover, Germany Umeå University, Department of Clinical Microbiology, Virology & Wallenberg Center for Molecular Medicine (WCMM), Sweden

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