Protein-Protein Interactions in Human Disease, Part B - 1st Edition - ISBN: 9780128143421, 9780128143438

Protein-Protein Interactions in Human Disease, Part B, Volume 111

1st Edition

Serial Volume Editors: Rossen Donev
eBook ISBN: 9780128143438
Hardcover ISBN: 9780128143421
Imprint: Academic Press
Published Date: 17th February 2018
Page Count: 294
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Table of Contents

Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design

Sitanshu S. Singh and Seetharama D. Jois

2. Targeting Intramembrane Protein–Protein Interactions: Novel Therapeutic Strategy of Millions Years Old

Alexander B. Sigalov

3. Targeting the Architecture of Deregulated Protein Complexes in Cancer

Eduard Stefan, Jakob Troppmair and Klaus Bister

4. Multifaceted Nucleolin Protein and Its Molecular Partners in Oncogenesis

Iva Ugrinova, Maria Petrova, Mounira Chalabi-Dchar and Philippe Bouvet

5. Subcellular Targeting of Nitric Oxide Synthases Mediated by Their N-Terminal Motifs

Carlos Costas-Insua, Javier Merino-Gracia, Clara Aicart-Ramos and Ignacio Rodríguez-Crespo

6. Development of Protein–Protein Interaction Inhibitors for the Treatment of Infectious Diseases

Andrew F. Voter and James L. Keck

7. Defining Pharmacological Targets by Analysis of Virus–Host Protein Interactions

Manuel Llano and Mario A. Peña-Hernandez

8. Investigating the Influence of Hotspot Mutations in Protein–Protein Interaction of IDH1 Homodimer Protein: A Computational Approach

D. Thirumal Kumar, P. Sneha, Jennifer Uppin, S. Usha and C. George Priya Doss

9. Human Interactomics: Comparative Analysis of Different Protein Interaction Resources and Construction of a Cancer Protein–Drug Bipartite Network

Javier De Las Rivas, Diego Alonso-López and Mónica M. Arroyo


Protein-Protein Interactions in Human Disease, Volume 111, Part B, promotes further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and locate new protein targets for drug development. Thus, this volume is of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in the field. In addition, these articles would be of great benefit to medical, biology and pharmacology students who specialize in this field.

Key Features

  • Describes advances in the application of powerful techniques in studying and analyzing protein-protein interactions
  • Ideal for a wide audience of researchers, specialists and students
  • Written by authorities in their field
  • Contains a number of high quality illustrations, figures and tables that support the presented information


Protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in this field. Articles published here would also be of great benefit to medical, biology and pharmacology students specializing in this field


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© Academic Press 2018
Academic Press
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Ratings and Reviews

About the Serial Volume Editors

Rossen Donev Serial Volume Editor

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Lecturer in Swansea University. Currently he is Director of Biomed Consult Ltd, UK. His major research interests include signalling pathways involved in neuropsychiatric disorders and tumour escape from the immune system, and development of therapeutic strategies for treatment. He has published more than 50 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks at Attention Deficit/Hyperactivity Disorder meetings. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals.

Affiliations and Expertise

Swansea University, Swansea, Wales, UK