Protein Modules and Protein-Protein Interactions, Volume 61

Protein Modules and Protein-Protein Interaction: Toward a Global View Structural Basis for Affinity and Specificity in Macromolecular Recognition Sequence Analysis of Multidomain Proteins: Past Perspectives and Future Directions Identification of Transiently Interacting Proteins and of Stable Protein Complexes Molecular Recognition in Antibody-Antigen Complexes Molecular Recognition by SH2 Domains How SH3 Domains Recognize Proline Structural Biology of eIF4F: mRNA Recognition and Preparation in Eukaryotic Translation Initiation

Protein modules engage in a multitude of interactions with one another and with other cellular components, notably with DNA. These interactions are a central aspect of protein function of great relevance in the post-genomic era. This volume describes a panel of approaches for analyzing protein modules and their interactions, ranging from bioinformatics to physical chemistry, to biochemistry, with an emphasis on the structure-function relationship in protein-protein complexes involved in cellular processes including signal transduction.

• Comprehensive overview of different facets of macromolecule interactions
• Computational and bioinformatics aspects of analyzing protein modules and their interactions
• Emphasis on structure-function relationship in protein-protein complexes involved in cellular processes

Biochemists, biophysicists, molecular biologists, immunologists