Protein modules engage in a multitude of interactions with one another and with other cellular components, notably with DNA. These interactions are a central aspect of protein function of great relevance in the post-genomic era. This volume describes a panel of approaches for analyzing protein modules and their interactions, ranging from bioinformatics to physical chemistry, to biochemistry, with an emphasis on the structure-function relationship in protein-protein complexes involved in cellular processes including signal transduction.

Key Features

Key Features * Comprehensive overview of different facets of macromolecule interactions * Computational and bioinformatics aspects of analyzing protein modules and their interactions * Emphasis on structure-function relationship in protein-protein complexes involved in cellular processes


Biochemists, biophysicists, molecular biologists, immunologists

Table of Contents

Protein Modules and Protein-Protein Interaction: Toward a Global View Structural Basis for Affinity and Specificity in Macromolecular Recognition Sequence Analysis of Multidomain Proteins: Past Perspectives and Future Directions Identification of Transiently Interacting Proteins and of Stable Protein Complexes Molecular Recognition in Antibody-Antigen Complexes Molecular Recognition by SH2 Domains How SH3 Domains Recognize Proline Structural Biology of eIF4F: mRNA Recognition and Preparation in Eukaryotic Translation Initiation


No. of pages:
© 2003
Academic Press
eBook ISBN:
Print ISBN:

About the serial-volume-editor

Joël Janin

Affiliations and Expertise

Laboratoire d'Enzymologie et Biochemie Structurales, France


@from:PRAISE FOR THE SERIES @qu:"The authority, originality, and editing of the reviews are first class." @source:—NATURE @qu:"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists." @source:—JOURNAL OF THE AMERICAN CHEMICAL SOCIETY