COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Protein Lipidation - 3rd Edition - ISBN: 9780121227227, 9780080542430

Protein Lipidation, Volume 21

3rd Edition

0.0 star rating Write a review
Serial Volume Editors: Fuyuhiko Tamanoi David Sigman
Hardcover ISBN: 9780121227227
eBook ISBN: 9780080542430
Imprint: Academic Press
Published Date: 17th October 2000
Page Count: 322
Sales tax will be calculated at check-out Price includes VAT/GST
124.00
165.00
115.50
100.00
150.00
Unavailable
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Preface. Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey. Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese. Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi. Farnesyltransferase Inhibitors, J.B. Gibbs. Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb. Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra. Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke. Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder. Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon. Chapter References. Author Index. Subject Index.


Description

This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.

Key Features

  • The enzymatic mechanisms of protein lipidation
  • Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase

Readership

Biochemists, molecular biologists, biotechnologists, researchers in biomedical and in pharmaceutical research, physiologists


Details

No. of pages:
322
Language:
English
Copyright:
© Academic Press 2001
Published:
17th October 2000
Imprint:
Academic Press
Hardcover ISBN:
9780121227227
eBook ISBN:
9780080542430

Ratings and Reviews


About the Serial Volume Editors

Fuyuhiko Tamanoi

Affiliations and Expertise

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

David Sigman

Affiliations and Expertise

University of California School of Medicine, Los Angeles, California, U.S.A.