Protein Lipidation

Protein Lipidation

3rd Edition - October 17, 2000

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  • Editors: Fuyuhiko Tamanoi, David Sigman
  • Hardcover ISBN: 9780121227227
  • eBook ISBN: 9780080542430

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Description

This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.

Key Features

  • The enzymatic mechanisms of protein lipidation
  • Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase

Readership

Biochemists, molecular biologists, biotechnologists, researchers in biomedical and in pharmaceutical research, physiologists

Table of Contents

  • Preface.
    Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey.
    Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese.
    Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi.
    Farnesyltransferase Inhibitors, J.B. Gibbs.
    Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb.
    Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra.
    Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke.
    Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder.
    Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon.
    Chapter References.
    Author Index.
    Subject Index.

Product details

  • No. of pages: 322
  • Language: English
  • Copyright: © Academic Press 2000
  • Published: October 17, 2000
  • Imprint: Academic Press
  • Hardcover ISBN: 9780121227227
  • eBook ISBN: 9780080542430

About the Serial Volume Editors

Fuyuhiko Tamanoi

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Affiliations and Expertise

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

David Sigman

Affiliations and Expertise

University of California School of Medicine, Los Angeles, California, U.S.A.

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