Description

This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.

Key Features

@introbul:Key Features @bul:* The enzymatic mechanisms of protein lipidation * Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase

Readership

Biochemists, molecular biologists, biotechnologists, researchers in biomedical and in pharmaceutical research, physiologists.

Table of Contents

Preface. Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey. Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese. Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi. Farnesyltransferase Inhibitors, J.B. Gibbs. Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb. Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra. Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke. Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder. Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon. Chapter References. Author Index. Subject Index.

Details

No. of pages:
322
Language:
English
Copyright:
© 2001
Published:
Imprint:
Academic Press
Print ISBN:
9780121227227
Electronic ISBN:
9780080542430