Protein Lipidation, Volume 21

3rd Edition

Serial Volume Editors: Fuyuhiko Tamanoi David Sigman
Hardcover ISBN: 9780121227227
eBook ISBN: 9780080542430
Imprint: Academic Press
Published Date: 17th October 2000
Page Count: 322
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Table of Contents

Preface. Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey. Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese. Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi. Farnesyltransferase Inhibitors, J.B. Gibbs. Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb. Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra. Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke. Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder. Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon. Chapter References. Author Index. Subject Index.

Description

This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.

Key Features

@introbul:Key Features @bul:* The enzymatic mechanisms of protein lipidation

  • Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase

Readership

Biochemists, molecular biologists, biotechnologists, researchers in biomedical and in pharmaceutical research, physiologists.


Details

No. of pages:
322
Language:
English
Copyright:
© Academic Press 2001
Published:
Imprint:
Academic Press
eBook ISBN:
9780080542430
Hardcover ISBN:
9780121227227

About the Serial Volume Editors

Fuyuhiko Tamanoi Serial Volume Editor

Professor Fuyu Tamanoi works at the Dept. of Microbiology, Immunology and Molecular Genetics at the University of California.

Affiliations and Expertise

University of California, Los Angeles, USA

David Sigman Serial Volume Editor

Affiliations and Expertise

University of California School of Medicine, Los Angeles, California, U.S.A.