This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Peptides, and Scaffolds

Key Features

  • Chapters provide an invaluable resource for academics, researchers and students alike
  • Iinternational board of authors
  • This volume is split into sections that cover subjects such as peptides, and scaffolds
  • Readership

    Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

    Table of Contents

    Part III: Peptides

    1. Stapled Peptides for Intracellular Drug Targets
    2. Gregory L. Verdine and Gerard J. Hilinski

    3. Mapping of vascular zip codes by phage display
    4. Tambet Teesalu, Kazuki N. Sugahara & Erkki Ruoslahti

    5. Engineering cyclic peptide toxins
    6. Richard J. Clark and David J. Craik

    7. Peptide Discovery using Bacterial Display and Flow Cytometry
    8. Jennifer A. Getz, Tobias D. Schoep, Patrick S. Daugherty

      Part V: Scaffolds

    9. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
    10. Rastislav Tamaskovic, Manuel Simon, Nikolas Stefan, Martin Schwill and Andreas Plückthun

    11. Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)
    12. Shohei Koide, Akiko Koide, and Daša Lipovšek

    13. Anticalins: small engineered binding proteins based on the lipocalin scaffold
    14. Michaela Gebauer and Arne Skerra

    15. T Cell Receptor Engineering
    16. Jennifer D. Stone, Adam S. Chervin, David H. Aggen, David M. Kranz

    17. Engineering Knottins as Novel Binding Agents
    18. Sarah J. Moore and Jennifer R. Cochran

      Part VI: Pharmacokinetics

    19. Practical Theoretic Guidance for the Design of Tumor Targeting Agents
    20. K. Dane Wittrup, Greg M. Thurber, Michael M. Schmidt, John J. Rhoden

    21. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier
    22. William M. Pardridge and Ruben J. Boado

    23. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells

    David B. Thompson, James J. Cronican, and David R. Liu


    No. of pages:
    © 2012
    Academic Press
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