Prostanoids - 1st Edition - ISBN: 9780080263915, 9781483147918


1st Edition

Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979

Editors: Valéria Kecskeméti
eBook ISBN: 9781483147918
Imprint: Pergamon
Published Date: 1st January 1980
Page Count: 184
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Prostanoids, Volume VI, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. Prostaglandin research is an exciting and rapidly developing field in chemical and biological sciences. It is the recently discovered prostacyclin that has brought about a breakthrough in prostaglandin research giving new impetus to clinical investigation. This volume contains 22 papers read at the ""Prostanoids Symposium"" by participants from eight different countries. Numerous new data concerning the synthesis of prostacyclin and different stable prostacyclin analogues are presented. Besides the problems of synthetic chemistry, data are given about the pharmacological properties of these prostacyclin analogues, analyzing their effects on heat and smooth muscles. Several papers dealing with the involvement of different pharmacologically active agents and hormones in the biosynthesis of prostaglandins emphasize the important role of prostanoids in various pathophysiological processes and diseases. The clinical use of prostacyclin, having already earned an outstanding position in medicine, is stressed.

Table of Contents


Synthesis and Pharmacology of New Prostacyclin Analogues

Recent Advances in Carboprostacyclin Synthesis

Pharmacological Activities of Carboprostacyclin

Modulation of Prostaglandin Biosynthesis by D-Penicillamine and Gold Derivatives

3-(1-Pyrazolyl)-Pyridazine Derivatives with Prostaglandin A Isomerase Inhibiting Effect

Malondialdehyde Formation as an Indicator of Prostaglandin Production by Platelets

Investigation of the Prostaglandin Synthesis

The Effect of Oestrone and Progesterone on Prostaglandin Metabolism in Brain

Interaction of Sodium Salicylate and Indomethacin in Rats as Shown by Prostacyclin Release from Gastric Mucosa

Prostaglandin-like Activity and Radiation-Induced Gastrointestinal Syndrome

Effect of Primary Prostaglandins and Prostacyclin on Cardiac Transmembrane Potentials

Comparative Effect of Prostacyclin and Primary Prostaglandins on Cardiac Transmembrane Currents

Sex Differences in Cardiovascular Activity of PGI2 and 6-PG1

Role of Prostaglandins in Coronary Regulation and Mode of Action of Antianginal Drugs

Influence of Linoleic Acid Deficient Diet on PG Metabolism and Blood Pressure of Salt Loaded Rats after Chemical Sympathectomy

Changes in Prostaglandin Biosynthesis in Spontaneously Hypertensive Rats after Administration of Antihypertensive Drugs

Dipyridamole in Advanced Atherosclerosis: PGI2 Induced cAMP Accumulation, Platelet Aggregation and Atherosclerotic Plaque Formation

Prostaglandins and Neurotransmitters

Actions of Prostacyclin PGI2 on Isolated Guinea-Pig Vas Deferens and Rabbit Pulmonary, Mesenteric and Ear Arteries

Prostacyclin - Clinical Implications of Biological Actions

Prostaglandins and Uterine Function

New Possibilities in the Treatment of Dysmenorrhea

Subject Index


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© Pergamon 1980
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About the Editor

Valéria Kecskeméti

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