Prostanoids - 1st Edition - ISBN: 9780080263915, 9781483147918


1st Edition

Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979

Editors: Valéria Kecskeméti
eBook ISBN: 9781483147918
Imprint: Pergamon
Published Date: 1st January 1980
Page Count: 184
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Prostanoids, Volume VI, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. Prostaglandin research is an exciting and rapidly developing field in chemical and biological sciences. It is the recently discovered prostacyclin that has brought about a breakthrough in prostaglandin research giving new impetus to clinical investigation. This volume contains 22 papers read at the ""Prostanoids Symposium"" by participants from eight different countries. Numerous new data concerning the synthesis of prostacyclin and different stable prostacyclin analogues are presented. Besides the problems of synthetic chemistry, data are given about the pharmacological properties of these prostacyclin analogues, analyzing their effects on heat and smooth muscles. Several papers dealing with the involvement of different pharmacologically active agents and hormones in the biosynthesis of prostaglandins emphasize the important role of prostanoids in various pathophysiological processes and diseases. The clinical use of prostacyclin, having already earned an outstanding position in medicine, is stressed.

Table of Contents

Preface Synthesis and Pharmacology of New Prostacyclin Analogues Recent Advances in Carboprostacyclin Synthesis Pharmacological Activities of Carboprostacyclin Modulation of Prostaglandin Biosynthesis by D-Penicillamine and Gold Derivatives 3-(1-Pyrazolyl)-Pyridazine Derivatives with Prostaglandin A Isomerase Inhibiting Effect Malondialdehyde Formation as an Indicator of Prostaglandin Production by Platelets Investigation of the Prostaglandin Synthesis The Effect of Oestrone and Progesterone on Prostaglandin Metabolism in Brain Interaction of Sodium Salicylate and Indomethacin in Rats as Shown by Prostacyclin Release from Gastric Mucosa Prostaglandin-like Activity and Radiation-Induced Gastrointestinal Syndrome Effect of Primary Prostaglandins and Prostacyclin on Cardiac Transmembrane Potentials Comparative Effect of Prostacyclin and Primary Prostaglandins on Cardiac Transmembrane Currents Sex Differences in Cardiovascular Activity of PGI2 and 6-PG1 Role of Prostaglandins in Coronary Regulation and Mode of Action of Antianginal Drugs Influence of Linoleic Acid Deficient Diet on PG Metabolism and Blood Pressure of Salt Loaded Rats after Chemical Sympathectomy Changes in Prostaglandin Biosynthesis in Spontaneously Hypertensive Rats after Administration of Antihypertensive Drugs Dipyridamole in Advanced Atherosclerosis: PGI2 Induced cAMP Accumulation, Platelet Aggregation and Atherosclerotic Plaque Formation Prostaglandins and Neurotransmitters Actions of Prostacyclin PGI2 on Isolated Guinea-Pig Vas Deferens and Rabbit Pulmonary, Mesenteric and Ear Arteries Prostacyclin - Clinical Implications of Biological Actions Prostaglandins and Uterine Function New Possibilities in the Treatment of Dysmenorrhea Subject Index


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Valéria Kecskeméti

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