Progress in Medicinal Chemistry, Volume 56

Chapter One: Enabling Chemistry Technologies and Parallel Synthesis—Accelerators of Drug Discovery Programmes

• Abstract
• 1 Introduction
• 2 The Evolution of Flow-Based Approaches to Synthesis
• 3 Use of High-Temperature Chemistries
• 4 Use of Photochemical and Electrochemical Reactions
• 5 Use of Hazardous Gases (e.g. Diazomethane) in Flow
• 6 Library Design Tools and Processes
• 7 Use of Flow Chemistry for Library Synthesis
• 8 Summary and Future Perspectives
• Acknowledgements

Chapter Two: Development of LRRK2 Inhibitors for the Treatment of Parkinson's Disease

• Abstract
• 1 Introduction
• 2 LRRK2 Biology
• 3 Structural Biology of LRRK2
• 4 Overview of Selective Inhibitors of LRRK2
• 5 Conclusion

Chapter Three: Recent Progress in the Discovery and Development of TRPA1 Modulators

• Abstract
• 1 TRPA1: An Introduction
• 2 Validation as a Target for Drug Discovery
• 3 Medicinal Chemistry and Clinical Status of TRPA1 Modulators
• 4 Recent Structural Insights
• 5 Conclusions and Outlook

Chapter Four: Small Molecule Inhibition of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)

• Abstract
• 1 Introduction
• 2 Small Molecule IRAK4 Inhibitor Discovery
• 3 Summary of Clinical Status
• 4 Conclusion

Progress in Medicinal Chemistry, Volume 56 provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development. Specific chapters cover timely topics, such as the development of LRRK2 inhibitors for the treatment of Parkinson's, and recent discoveries and developments in TRPA1 modulators.

Users will find a comprehensive resource on the topic of medicinal chemistry that also discusses avenues for the acceleration of drug discovery programs.

• Extended, timely reviews of topics in medicinal chemistry
• Contains targets and technologies relevant to the discovery of tomorrow’s drugs
• Presents analyses of successful drug discovery programs

Everyone interested in the strategy and practice of the preclinical phases of the creation of new medicines. Those wishing to understand the drivers of drug design or expand their knowledge of therapeutic target classes