Progress in Medicinal Chemistry

Progress in Medicinal Chemistry

1st Edition - June 17, 2022

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  • Editors: David Witty, Brian Cox
  • Hardcover ISBN: 9780323989039
  • eBook ISBN: 9780323989046

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Progress in Medicinal Chemistry, Volume 61 provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors.

Key Features

  • Provides extended, timely reviews of topics in medicinal chemistry
  • Contains targets and technologies relevant to the discovery of tomorrow’s drugs
  • Presents analyses of successful drug discovery programs


Everyone interested in the strategy and practice of the preclinical phases of the creation of new medicines. Those wishing to understand the drivers of drug design or expand their knowledge of therapeutic target classes

Table of Contents

  • Cover
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Hearing loss drug discovery and medicinal chemistry: Current status, challenges, and opportunities
  • Abstract
  • 1: Introduction
  • 2: Global hearing therapeutics portfolio
  • 3: Human hearing and anatomy
  • 4: Inner ear drug delivery
  • 5: Types of hearing loss
  • 6: Measuring hearing loss
  • 7: Otoprotectants for the prevention of hearing loss
  • 8: Restoration of hearing and regenerative medicines
  • 9: Next generation small molecule hearing loss therapeutics
  • 10: Conclusion
  • Acknowledgements
  • References
  • Chapter Two: Advances in the design of new types of inhaled medicines
  • Abstract
  • 1: Introduction
  • 2: The lung as an organ of administration
  • 3: Drug distribution and metabolism
  • 4: New modalities
  • 5: Clinical status of inhaled new modalities
  • 6: Summary
  • Acknowledgments
  • References
  • Chapter Three: The importance of plasma protein and tissue binding in a drug discovery program to successfully deliver a preclinical candidate
  • Abstract
  • 1: Protein binding and the free drug hypothesis
  • 2: Plasma proteins
  • 3: Tissue distribution
  • 4: Measurement of plasma protein and tissue binding
  • 5: The role of binding in pharmacokinetics
  • 6: Mechanism-based PK/PD
  • 7: Binding as an optimisable parameter
  • 8: Summary
  • References

Product details

  • No. of pages: 224
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: June 17, 2022
  • Imprint: Elsevier
  • Hardcover ISBN: 9780323989039
  • eBook ISBN: 9780323989046

About the Editors

David Witty

David Witty
Dr David Witty has more than 20 years experience in the pharmaceutical industry as a medicinal chemist and project leader working principally in areas of anti-infectives, metabolic diseases, cognition and pain, delivering clinical candidates for several conditions. He led IT Strategy within the Neurology division of GSK, developing and deploying the first Electronic Notebooks for drug discovery to sites in the UK and Singapore. He has contributed more than 90 scientific papers, reviews, patents and books on medicinal and synthetic chemistry.

In 2010 David and several colleagues successfully raised $35M in venture funding to found Convergence Pharmaceuticals, a specialist ion channel company focused on the development of novel treatments for pain, based in Cambridge UK. David presently leads their discovery programme and manages scientific operations within the business.

David is chairman of the Fine Chemicals Group of the Society of Chemical Industry, with responsibility for the delivery of conferences, seminars and training courses for chemists throughout the UK and Europe, and advising parliamentary bodies on matters of relevance to the UK chemical industry.

Since 2008 David has been a STEM ambassador for SETPOINT, introducing school students at both primary and secondary level to the excitement and possibilities of pursuing scientific careers, through workshops, lectures and competitions.

Affiliations and Expertise

WITNET LTD, Cambridge, UK

Brian Cox

Professor Brian Cox is at University of Sussex, Brighton, UK

Affiliations and Expertise

Professor, University of Sussex, Brighton, UK

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