Progress in Hodgkin's Disease - 1st Edition - ISBN: 9780123649331, 9781483276045

Progress in Hodgkin's Disease

1st Edition

Editors: G. W. Richter Kim Solez
eBook ISBN: 9781483276045
Imprint: Academic Press
Published Date: 14th January 1992
Page Count: 236
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International Review of Experimental Pathology, Volume 33: Progress in Hodgkin's Disease summarizes the progress made in the diagnosis and understanding of the pathogenesis of Hodgkin's disease. The first half of this volume deals with diagnostic aspects, whereas the second half focuses on recent developments in the understanding of the pathogenesis of Hodgkin's disease.
The book opens with a chapter on the differential diagnosis between Hodgkin's disease and non-Hodgkin's lymphomas, and provides guidelines on how to deal with the grey areas between these two groups of diseases. Separate chapters follow on the criteria for a prognostically relevant histological grading of the most common subtype of Hodgkin's disease; data on the nodular lymphocyte predominance subtype of Hodgkin's disease; and the various reagents used to define the immunophenotype of Reed-Sternberg cells. Subsequent chapters deal with potential mediators of lymphocyte agglutination to Reed-Sternberg cells; immunological alterations in Hodgkin's disease; molecular genetic studies into the pathogenesis of Hodgkin's disease; and results of studies on Hodgkin cell lines. This book provides data that go beyond those covered in textbooks in pathology and hematology and should be of interest to all pathologists and clinicians dealing with the diagnosis and management of Hodgkin's disease, as well as to lymphoma researchers.

Table of Contents



Differential Diagnosis between Hodgkin's Disease and Non-Hodgkin's Lymphoma

I. Introduction

II. Low Grade B Cell Lymphoma

III. Pleomorphic ("Peripheral") T Cell Lymphomas

IV. Large Cell Lymphoma and Anaplastic Large Cell Lymphoma

V. Conclusions


Diagnosis and Grading of Nodular Sclerosing Hodgkin's Disease: A Study of 2190 Patients

I. Introduction

II. Patient Population

III. Histological Criteria

IV. The Clinical Relevance of Grading NS

V. Discussion


Lymphocyte-Predominance Hodgkin's Disease

I. History

II. Histology

III. Cytology of L&H Type RS Cells

IV. Immunophenotype of L&H Type RS Cells

V. Nodular Lymphocyte-Predominance Hodgkin's Disease Cell Lines

VI. Immunophenotype of B Cells

VII. Immunophenotype of T Cells

VIII. Relation to Progressively Transformed Germinal Centers

IX. Large Cell Lymphomas

X. Diffuse Variants of Nodular LPHD (Diffuse Paragranuloma)

XI. Clinical Features of NLPHD

XII. Conclusion


Immunophenotype of Reed-Sternberg Cells

I. Introduction

II. Activation Antigens

III. Lymphoid Markers

IV. Other Antigens

V. Conclusion


The Nature and Function of the Hodgkin's Cell Lectin and Its Role in Lymphocyte Agglutination

I. Introduction

II. Dual Role of the Hodgkin's Cell Lectin as Carbohydrate-Binding Protein and Ectosialyltransferase

III. Relationship between the Hodgkin's Cell Lectin and the Hepatic Asialoglycoprotein Receptor

IV. Subcellular Distribution of the Hodgkin's Cell Lectin

V. Hodgkin's Cell Lectin as a Lymphocyte Agglutinant and Mitogen

VI. Expression of the Hodgkin's Cell Lectin in Disease-Involved Human Tissues


Role of T Cells in the Pathogenesis off Hodgkin's Disease

I. Introduction

II. Possible Relationship between Immune Alterations and Pathogenesis of the Disease

III. Pathogenic Hypothesis


Gene Analysis and Epstein-Barr Viral Genome Studies of Hodgkin's Disease

I. Introduction

II. Antigen Receptor Gene Analysis of Hodgkin's Disease

III. Molecular Studies of Epstein-Barr Virus in Hodgkin's Disease

IV. In Situ Hybridization Studies for the Identification of Reed-Sternberg Cell mRNA: Interleukin-5

V. Studies on the Molecular Cytogenetics of Hodgkin's Disease


Hodgkin's Disease: Analysis of Cell Line Data

I. Introduction

II. The Cell of Origin in Hodgkin's Disease

III. The Cellular Pathogenesis of Hodgkin's Disease

IV. Conclusions



Contents of Recent Volumes


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© Academic Press 1992
Academic Press
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About the Editor

G. W. Richter

Kim Solez

Affiliations and Expertise

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton

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