Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 23 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2010.

As with previous volumes in the series, Volume 23 apprises academic/industrial chemists and advanced students of developments in heterocyclic chemistry in a convenient format.

Key Features

* Covers the heterocyclic literature published in 2010
* Includes specialized reviews
* Features contributions from leading researchers in their fields


Academic and industrial chemists and advanced students interested in heterocyclic chemistry

Table of Contents

Series Page

Editorial Advisory Board Members Progress in Heterocyclic Chemistry

Chapter 1: Recent Advances in the Synthesis of Aspidosperma-Type Alkaloids

1.1. Introduction

1.2. Aspidospermine and aspidospermidine

1.3. Aspidofractinine

1.4. Tabersonine

1.5. Subincanadines

1.6. Meloscine

1.7. Miscellaneous approaches to the general aspidosperma core

1.8. Vindoline, vinblastine, and vincristine

1.9. Aspidophytine and haplophytine

1.10. Conophylline and conophyllidine

Chapter 2: Synthesis of Heterocycles by Palladium-Catalyzed Intramolecular Heteroarylation

2.1. Introduction and scope of the review

2.2. Annulation of five-membered aza-rings

2.3. Annulation of six-membered aza-rings

2.4. Annulation of medium size aza-rings

2.5. Macrocycles

2.6. Tandem sequences, cascades, and miscellaneous cyclizations

2.7. Conclusions

Chapter 3: Three-Membered Ring Systems

3.1. Introduction

3.2. Epoxides

3.3. Aziridines

Chapter 4: Four-Membered Ring Systems

4.1. Introduction

4.2. Azetidines, azetines, and related systems

4.3. Monocyclic 2-azetidinones (β-lactams)

4.4. Fused and spirocyclic β-lactams

4.5. Oxetanes, dioxetanes, dioxetanones, and 2-oxetanones (β-lactones)

4.6. Thietanes and related systems

4.7. Silicon and phosphorus heterocycles: Miscellaneous

Chapter 5.1: Five-Membered Ring Systems

5.1.1. Introduction

5.1.2. Reviews, accounts, and books on thiophene, selenophene, and tellurophene chemistry

5.1.3. Synthesis of thiophenes

5.1.4. Elaboration of thiophenes and benzothiophenes

5.1.5. Synthesis of thiophenes for use in material science

5.1.6. Thiophene derivatives in medicinal chemistry

5.1.7. Selenophenes and tellurophenes

Chapter 5.2: Five-


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About the editors

Gordon Gribble

Gordon Gribble is the Dartmouth Professor of Chemistry at Dartmouth College, Hanover, USA. His research program covers several areas of organic chemistry, most of which involve synthesis, including novel indole chemistry, triterpenoid synthesis, DNA intercalation, and new synthetic methodology. Prof Gribble also has a deep interest in naturally occurring organohalogen compounds, and in the chemistry of wine and wine making.

John Joule

John Arthur Joule did his BSc, MSc, and PhD degrees at The University of Manchester, obtaining his PhD in 1961. He then undertook post-doctoral work at Princeton University and Stanford University, before joining the academic staff of the Chemistry Department at The University of Manchester in 1963, where he is currently a Professor. In 1996 he received an RSC Medal for Heterocyclic Chemistry.