Progress in Chemical Toxicology

Progress in Chemical Toxicology

Volume 2

1st Edition - January 1, 1965

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  • Editor: Abraham Stolman
  • eBook ISBN: 9781483224909

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Progress in Chemical Toxicology, Volume 2 reviews significant developments in chemical toxicology, with particular reference to the mode of absorption, distribution, excretion, and metabolism of drugs and poisons in both humans and animals. Some of the techniques for the rapid infrared analysis and identification of gases in human breath are also discussed, along with rapid drug analysis by ion-exchange paper chromatography and ionophoresis. Comprised of six chapters, this volume first deals with the absorption, distribution, and excretion of poisons and their metabolites, including drugs extractable by organic solvents from aqueous acid and alkaline solutions. Subsequent chapters focus on the use of rapid infrared techniques in the detection of volatile organic compounds and toxic gases in humans; rapid methods of toxicological analysis by ion-exchange paper chromatography and ionophoresis; sample preparation and techniques for concentration of metal poisons for increased sensitivity of spectrographic analysis; and application of thin layer chromatography in toxicology. An approach to the analysis of biological specimens for basic drugs is also described. This book will be of interest to chemists and toxicologists.

Table of Contents

  • Contributors


    The Absorption, Distribution, and Excretion of Poisons and their Metabolites

    I. Gas and Vapors (Poisons through Inhalation)

    II. Volatile Liquids (Steam Volatile)

    III. Drugs Extractable by Organic Solvents from Aqueous Acid Solution

    IV. Drugs Extractable by Organic Solvents from Aqueous Alkaline Solution

    V. Metallic Poisons


    Detection of Volatile Organic Compounds and Toxic Gases in Humans by Rapid Infrared Techniques

    I. Introduction

    II. Infrared Analysis of Expired Breath

    III. Infrared Analysis of Solvent Extractions of Body Fluids

    IV. Infrared Analysis of Solvent Extractions of Tissues

    V. Identification and Interpretation of Infrared Spectra


    An Approach to the Analysis of Biological Specimens for Basic Drugs

    I. Introduction

    II. Analytical Procedure


    Rapid Methods of Toxicological Analysis by Ion-Exchange Paper Chromatography and Ionophoresis

    I. The Use of Modified Cellulose Ion-Exchange Sheets in Toxicological Analysis

    II. Rapid Separation of Drugs by Chromatography at Elevated Temperatures on Ester-Impregnated Paper

    III. Rapid Identification of Mixtures of Barbiturates by Heating with Concentrated Sulfuric Acid


    Developments in Spectrography: Sample Preparation

    I. Introduction

    II. Destruction of Organic Matter

    III. Concentration, Isolation, Enrichment


    Thin Layer Chromatography Application in Toxicology

    I. Introduction

    II. Adsorbents

    III. Preparation of Plates

    IV. Coating the Plates

    V. Activation of Layers

    VI. Application of Samples

    VIL Development of Plates

    VIII. Solvents

    IX. Qualitative Estimation

    X. Documentation of Results

    XI. Elution of Drugs

    XII. Specific Examples of Separation of Drugs


    Author Index

    Subject Index

Product details

  • No. of pages: 426
  • Language: English
  • Copyright: © Academic Press 1965
  • Published: January 1, 1965
  • Imprint: Academic Press
  • eBook ISBN: 9781483224909

About the Editor

Abraham Stolman

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