Description

Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application.

Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair.

With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology.

Key Features

  • Reviews the range of progenitor and stem cells available and outlines their therapeutic application
  • Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells
  • Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies

Readership

Physicians and scientists interested in transplanting scientific discovery into clinical therapies; scientists involved in regenerative medicine therapies; researchers in stem cell biology and bioengineering

Table of Contents

Dedication

Contributor contact details

Introduction

Part I: Basic principles of stem cells

Chapter 1: Basic principles for stem cell culture

Abstract:

1.1 Introduction

1.2 Understanding and standardization of in vitro culture systems

1.3 Quality assurance

1.4 Documentation

1.5 Safety

1.6 Legal, ethical and regulatory compliance

1.7 Education and training

1.8 Conclusion

1.9 Acknowledgement

Chapter 2: Basic principles of human embryonic stem cells

Abstract:

2.1 Introduction: biological properties of human embryonic stem cells (hESC)

2.2 Historical overview

2.3 Human embryonic stem cells (hESC) in therapy – current status and strategies for the future

2.4 Human embryonic stem cells (hESC) in drug discovery – current status and strategies for the future

2.5 Specific mutation-carrying (SMC) human embryonic stem cells (hESC)

2.6 Human embryonic stem cells (hESC) utilization, the next step

2.7 Conclusion

Chapter 3: Basic principles in generating induced pluripotent stem cells

Abstract:

3.1 Introduction

3.2 Evolution of reprogramming and the birth of induced pluripotency

3.3 Current methods for induced reprogramming

3.4 Conclusions and future prospects

Chapter 4: Basic principles of amniotic fluid and placenta stem cells

Abstract:

4.1 Introduction

4.2 Amniotic fluid and placenta in developmental biology

4.3 Isolation and characterization of progenitor cells

4.4 Differentiation of amniotic fluid- and placenta-derived progenitor cells

4.5 In vivo behavior of amniotic fluid stem cells

4.6 Amniotic fluid and placenta for cell therapy

4.7 Conclusion

4.8 Acknowledgment

Chapter 5: Basic principles of cord blood stem cells

Abstract:

Details

No. of pages:
568
Language:
English
Copyright:
© 2012
Published:
Imprint:
Woodhead Publishing
Print ISBN:
9781845699840
Electronic ISBN:
9780857096074

About the editor

Anthony Atala

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs. Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of the Journal of Tissue Engineering and Regenerative Medicine, The Journal of Rejuvenation Research, Nanotechnology in Engineering and Medicine, Gene Therapy and Regulation, and Current Reviews in Urology; as Executive Board Member or Section Editor of the journal Tissue Engineering and International Journal of Artificial Organs, and as Editorial Board member of the International Journal of Stem Cells, Stem Cell Review Letters, Expert Opinion on Biological Therapy, Biomedical Materials, Recent Patents on Regenerative Medicine, the Journal of the American College of Surgeons, the Journal of Urology, BMC Urology, Urology, and Current Opinion in Urology. Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, and the Gold Cystoscope Award for advances in his field. Dr. Atala was named by Scientific American as a Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue and organ regeneration. In 2006, he was named by Fast Company magazine as one of 50 people who “will change how we work and live over the next 10 years. Dr. Atala’s work was listed as Discover Magazine`s Number 1 Top Science Story of the Year in the field of medicine, and as Time Magazine’s top 10 medical breakthroughs of the year in 2007. A Time Magazine poll ranked Dr. Atala as the 56

Affiliations and Expertise

Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Reviews

I would recommend this book to anyone looking at translational work with cell-based therapy. In a few succinct chapters the reader will understand who works in the field, what the issues with starting the cell culture process are, what alternative cell types exist and how to navigate the complex terrain of regulatory and licensing requirements., Mahendra Rao, Stem Cell Reviews and Reports