Process Intensification for Chemical and Biotechology Industries

Process Intensification for Chemical and Biotechology Industries

Fundamentals and Applications to Critical and Advanced Processes

1st Edition - January 1, 2023

Write a review

  • Authors: Shirish Sonawane, Sarang Gumfekar, Bharat Bhanvase
  • Paperback ISBN: 9780323951777

Purchase options

Purchase options
Available for Pre-Order
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Process Intensification for Chemical Engineering and Biotechnology Industries: Fundamentals and Applications to Critical and Advanced Processes shows the importance of process intensification in the pharmaceutical, chemical, and biotechnology industries. The book provides mathematical aspects such as modeling of improved crystallization processes for the design of novel process intensification equipment.  The book is an indispensable resource for researchers in the pharmaceutical, chemical, and biotechnology industries, covering the fundamentals of process intensification, equipment used for fabrication, and the implementation of novel trends in process intensification that are cost effective and produce minimum waste and high yield.

Key Features

  • Covers the scientific, fundamental, engineering, and applied aspects of process intensification
  • Analyzes the pros and cons of various intensified equipment and design methodologies
  • Focuses on process intensification in biotechnology, chemical engineering and materials engineering
  • Offers a relevant reference for current needs in the pharmaceutical and food industries


Postgraduate and PhD students, researchers in academia and industry, chemical process engineers, industry practitioners in chemical engineering, biotechnology, and materials science working in the area of corrosion, pharmaceuticals, and food technology

Table of Contents

  • 1. Introduction to Process Intensification
    History, Introduction: Techniques of PI Applications, The Philosophy and opportunities of Process Intensification; Main benefits from process intensification Process intensification toolbox, Techniques for PI application Static mixers, microreactors, Higee Reactors, HEX Reactors, compact heat exchangers, Monolithic reactors. Reactive distillation and absorption, integrated reactor–separator systems, membrane assisted separations, membrane chromatography. Membrane separation processes. Dividing wall columns. Ultrasound reactors microwave reactors, Superctrical Fluid extraction. Sustainable design and role of process intensification. Economic analysis of newer processes. Role of Process intensification in Circular economy.

    2. Micro actor and Micro reaction technology
    Process Intensification Through Micro Reaction Technology: Effect of miniaturization on unit operations and reactions, Implementation of Micro reaction Technology, From Basic Properties To Technical Design Rules. Inherent Process Restrictions in Miniaturized Devices and Their Potential Solutions, Process control safety, enhancement of heat and mass transfer, Micro fabrication of unit operation and reactor devices, Wet and dry etching process. Case studies of nitration reaction/ exothermic reactions in microreactor. Dean Number, Capillary number, effect of diffusional resistance, Newton number, quantitative analysis of flow, heat using computational fluid dynamics. Quantitative analysis of slug flow in capillary reactors.

    3. Reactive Distillation & Reactive Separation Processes:
    Characteristics of Reactive Distillation, Applications of reactive Distillation, Motives behind the applications of RD. Constrains and Difficulties for implementation of RD. Modeling Principles of Reactive Distillation, Design of reactive distillation column, Case studies of RD: MTBE, DIPE, Energy Utilization and Selectivity Engineering. (Ethylene Glycol from Ethylene Oxide), RD for close-boiling mixtures, Modelling of Reactive Distillation Equilibrium-stage (EQ) models, Rate based (NEQ)model. Various methods for packing heterogeneous catalyst in columns and column structural modification (like RD with side-draw, RD with divided-wall etc. Advance optimization and advance process control strategies for RD Case study of ethyl acetate production using reactive distillation

    4 Use of Alternative Energy Sources for the Initiation and Execution of Chemical Reactions and Processes
    Possibilities for alternative energy input, Ultrasound Cavitation, Hydrodynamic Cavitation, Ultrasound Atomization, Fundamentals of Acoustic Cavitation and Sonochemistry, Theory of Cavitation and Design Aspects of Cavitational Reactors, Cavitation Generation and Usage Without Ultrasound: Hydrodynamic Cavitation, Sonochemical Synthesis of Metal Nanoparticles, Sonoelectrochemical Synthesis of Materials.

    5. Microwave Assisted Organic Synthesis
    Microwave-assisted reactions and processes: background, Microwave-assisted reactions and processes: basics, Technical possibilities for carrying out microwave-assisted reactions and Separations, Comparison between available microwave systems for synthesis.

    6. Compact heat exchangers
    HEX Reactor: Concepts, HEX Reactor Types, Plate heat exchangers Classification of Plate HXs, The Characteristic Parameter, Controlled Designs an Economic Design, Design & Analysis of Plate HXs, Factors Influencing design UA Criteria, Design Considerations for Compact Heat Exchangers.

    7. Dividing Wall Column
    The Petlyuk Column origin, Distillation process in a Petlyuk Column, Distinguishing features, Design of the Petlyuk Column, Simplified model of the Petlyuk Column, Dynamic behaviour and Models. Advance optimization and advance process control strategies for DWC.

    8. Spinning Disc Reactor
    Exploitation of Centrifugal Fields, The Nusselt-Flow Model, Liquid film on a rotating disc., The maximum film velocity, Mass & Heat Transfer on rotating disc reactors, Film-Flow Instability. Case study of neutralization reaction for production of nanoparticles using Spinning Disc Reactor. Determination of film thickness and time required to complete the reaction.

    9. Super critical Fluids
    Beyond the Critical Point, Properties of supercritical fluids, Phase diagram---(P---T), Density Diffusivity/Viscosity considerations, Supercritical fluid extraction

    10. Inline and High-Intensity Mixers
    Mixing concepts, mixing and reaction, mixing performance of inline mixers, gas–liquid mixing, liquid–liquid dispersions, Static Mixer Designs and Applications, Potential advantages of static mixer compared to mechanically agitated vessels. Fundamentals of Static Mixers: Mixing of Miscible Fluids Distributive Mixing, Low Pressure Drop Static Mixers for Turbulent Flow Processes, Commercially available static mixers. Classification of unit operations using static mixers. Droplet size determination method and Lang equation added in atomization chapter.

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Elsevier 2023
  • Published: January 1, 2023
  • Imprint: Elsevier
  • Paperback ISBN: 9780323951777

About the Authors

Shirish Sonawane

Professor Shirish Sonawane currently workings as Professor at NIT Warangal India and head SRIC center for sponsored research and Industrial Consultancy. He has published more than 200 SCI journal and 36 book chapters and 2 books. He has filed 19 patents out of them 6 patent he been granted. Presently 2 PDF, 7 PhD and 2 M. Tech students are working and 17 Ph.Ds are awarded. Sonoprocess engineering, cavitation based Nanotechnology, Waste water treatment, process development for nanoparticle synthesis, polymer nanocomposite etc. are some of the interest fields. He received funding from MeitY, Govt. of India (2021) and DST WTI project, Govt. of India (2021), earlier he got international projects such as Indo-Tunisia Bilateral Project sponsored by DST, Govt. of India (2017), Indo-Russia DST-RFBR (2018), IMPRINT SERB project (2020), BIRAC-SRISTI- GYTI project, Govt. of India (2017), Department of Information and Technology, Government of India (2014). He is having more than 6000 citations. He is having international collaborations with Australia, Portugal, Russia, Malaysia, Tunisia etc. Dr. Sonawane had also dealt with 19 consultancy projects and 25 Research and development projects sponsored by various international and Indian government agencies and few of the projects are transferred in technology form to respective organization or industry. Dr. Shirish Sonawane has effectively combined synthesis and characterization of novel nano materials for successful application in state of the art processes such as paints, coatings, nano fluids, wastewater treatment, nanofiltration, fuel cells, and membranes. He is recipient of BOYSCAST Fellowship from DST, (2008-2009); Heritage Fellowship from Erasmus Mundus Program (European commission) in 2013; DST Young Scientists award (2007); Institution of Engineers India award (2016); Fellow of Maharashtra Academy of Sciences award (2016); (2017), BIRAC-SRISTI- GYTI award (2017), V.N.M.M award from IIT-Roorkee (2017), Fellow of Telangana Academy of Sciences award (2017), Institution of Engineers India (2017), Alexander Von Humboldt Connect Program Germany (2020), NASI member (2020), NAWA (2020), IIChE Award for the Year 2020: Hindustan Dorr-Oliver Award (2020). He is the editorial board member of Ultrasonics Sonochemistry, Nanoscience, Advances in Nanoparticles; Journal of Foods and Raw materials; Biotechnology, Chemical & Environmental Engineering and Chief Editor of Scientific Journal of Bulletin of the SUS University Series -Food and Biotechnology. He is the reviewer of several international journals.

Affiliations and Expertise

Professor and Head, Chemical Engineering Department, National Institute of Technology Warangal, Telangana State, India

Sarang Gumfekar

Prof. Sarang Gumfekar is currently working as an Assistant Professor of Chemical Engineering at the Indian Institute of Technology, Ropar, India. He obtained his PhD in Chemical Engineering from University of Alberta, Canada. He was also awarded Marie Skłodowska-Curie Fellowship. His research is focused on process intensification in polymerization and nanomaterial synthesis, and water treatment techniques. Prof. Gumfekar serves as an Associate Editor of the Canadian Journal of Chemical Engineering and a Guest Editor of Processes. He is an Elected as Young Associate of the Maharashtra Academy of Sciences

Affiliations and Expertise

Assistant Professor, Chemical Engineering Department, Indian Institute of Technology, Ropar, India

Bharat Bhanvase

Dr. Bharat A. Bhanvase is currently working as Professor and Head in Chemical Engineering Department at the Laxminarayan Institute of Technology, RTM Nagpur University, Nagpur, Maharashtra, India. His research interests focus on Wastewater Treatment, Solid Waste Management, Cavitation based processes for production, Nanomaterials and Nanocomposites, Process Intensification, Microfluidics, and Nanofluids. He obtained Ph.D. in Chemical Engineering from University of Pune. He has written 29 book chapters in internationally renowned books, 3-edited book. Further, he is a recipient of the Young Scientists (Award) start- up research grant from Science and Engineering Research Board, New Delhi (India) in the year 2015. Also he was the recipient of Best Scientist Award from Rashtrasant Tukadoji Maharaj Nagpur University in 2017.

Affiliations and Expertise

Professor and Head in Chemical Engineering Department, Laxminarayan Institute of Technology, RTM Nagpur University, Nagpur, Maharashtra, India

Ratings and Reviews

Write a review

There are currently no reviews for "Process Intensification for Chemical and Biotechology Industries"