Principles of Regenerative Medicine

Principles of Regenerative Medicine

2nd Edition - December 7, 2010

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  • Editors: Anthony Atala, Anthony Atala, Robert Lanza, James Thomson, Robert Nerem
  • eBook ISBN: 9780123814234

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Description

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.

Key Features

  • Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology
  • The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine
  • New discoveries from leading researchers on restoration of diseased tissues and organs

Readership

Advanced researchers in bioengineering, stem cell biology, and developmental biology.

Table of Contents

  • 1 Molecular Organization of Cells
    2 Cell-ECM interactions In Repair and Regeneration
    3 Developmental Mechanisms of Regeneration
    4 The molecular basis of pluripotency in Principles of Regenerative Medicine
    5 How cells change their phenotype
    6 Scarless Wound Healing
    7 Somatic Cloning and Epigenetic Reprogramming in Mammals
    8 Engineered Proteins for Manipulating Gene Expression and Genome Sequence
    9 Genetic Approaches in Human Embryonic Stem Cells and Their Derivatives
    10 Embryonic Stem Cells: Derivation and Properties
    11 Alternate Sources of human embryonic stem cells
    12 Stem cells derived from amniotic fluid and placenta
    13 Induced Pluripotent stem cells
    14 Mesenchymal Stem cells Derived from Bone Marrow
    15 Multipotent adult progenitor cells
    16 Mesenchymal Stem cells
    17 Hepatic Stem Cells and Therapy
    18 Cardiac stem cells
    19 Skeletal muscle stem cells
    20 Stem Cells Derived from Fat
    21 Stem Cells Derived from Peripheral Blood
    22 Islet Cell Therapy and Pancreatic Stem Cells
    23 Regenerative Medicine for Diseases of the Retina
    24 Somatic cells: Growth and expansion potential of T Lymphocytes
    25 Mechanical  Determinants of Tissue Development
    26 Morphogenesis and Morphogenic Proteins
    27 Physical stress as a factor in tissue growth and remodeling
    28 Intelligent Surfaces for Cell Sheet Engineering
    29 Applications of Nanotechnology in Regenerative Medicine
    30 Design Principles in Biomaterials and Scaffolds
    31 Natural Origin Materials- Processing, Modification and Performance
    32 Synthetic Polymers
    33 Collagen Based Scaffold Materials
    34 Hydrogels
    35 Surface Modification of Biomaterials
    36 Histogenesis in Three-Dimensional Scaffolds
    37 Biocompatibility and Bioresponse to biomaterials
    38 Mechano-inducible systems for stem cells
    39 Biomineralization and Bone Regeneration
    40 Cell therapy for blood substitutes
    41 Articular Cartilage
    42 Implantation of Myogenic Cells in Skeletal Muscles
    43 Clinical islet transplantation
    44 Fetal Tissues
    45 Engineering of Large Diameter Vessels
    46 Engineering of Small Diameter Vessels
    47 Cardiac Tissue
    48 Regenerative Medicine in the Cornea
    49 Alimentary Tract
    50 Extracorporeal Kidney Support
    51 Tissue Engineering of the Reproductive System
    52 Cartilage Tissue Engineering
    53 Functional Tissue Engineering of Ligament and Tendon Injuries
    54 Central Nervous System
    55 Peripheral Nervous System

    56 Tissue Engineeing of Skin
    57 Tissue Engineering of the Respiratory Tree
    58 Ethical Considerations
    59 US Stem Cell Research Policy
    60 Overview of FDA Regulatory Process

Product details

  • No. of pages: 1202
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: December 7, 2010
  • Imprint: Academic Press
  • eBook ISBN: 9780123814234

About the Editors

Anthony Atala

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs.

Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of the Journal of Tissue Engineering and Regenerative Medicine, The Journal of Rejuvenation Research, Nanotechnology in Engineering and Medicine, Gene Therapy and Regulation, and Current Reviews in Urology; as Executive Board Member or Section Editor of the journal Tissue Engineering and International Journal of Artificial Organs, and as Editorial Board member of the International Journal of Stem Cells, Stem Cell Review Letters, Expert Opinion on Biological Therapy, Biomedical Materials, Recent Patents on Regenerative Medicine, the Journal of the American College of Surgeons, the Journal of Urology, BMC Urology, Urology, and Current Opinion in Urology.

Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, and the Gold Cystoscope Award for advances in his field. Dr. Atala was named by Scientific American as a Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue and organ regeneration. In 2006, he was named by Fast Company magazine as one of 50 people who “will change how we work and live over the next 10 years. Dr. Atala’s work was listed as Discover Magazine`s Number 1 Top Science Story of the Year in the field of medicine, and as Time Magazine’s top 10 medical breakthroughs of the year in 2007. A Time Magazine poll ranked Dr. Atala as the 56th most influential person of the year in 2007. Esquire Magazine in 2008 named Dr. Atala one of the 75 most influential persons of the 21st century. Fast Company Magazine named Dr. Atala one of 100 Most Creative People in Business in 2009. Dr. Atala was featured in U.S. News & World Report as one of “14 Medical Pioneers Who Aren’t Holding Back.”

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, and the National Institutes of Health Bioengineering Consortium. He is currently an NIH “Quantum Grant” awardee. Dr. Atala heads a team of over 250 physicians and researchers. Ten applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is the editor of nine books, including Minimally Invasive Urology, Methods of Tissue Engineering, Principles of Regenerative Medicine, and Foundations of Regenerative Medicine, and has published more than 300 journal articles and has applied for or received over 200 national and international patents.

Affiliations and Expertise

Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Anthony Atala

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs.

Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of the Journal of Tissue Engineering and Regenerative Medicine, The Journal of Rejuvenation Research, Nanotechnology in Engineering and Medicine, Gene Therapy and Regulation, and Current Reviews in Urology; as Executive Board Member or Section Editor of the journal Tissue Engineering and International Journal of Artificial Organs, and as Editorial Board member of the International Journal of Stem Cells, Stem Cell Review Letters, Expert Opinion on Biological Therapy, Biomedical Materials, Recent Patents on Regenerative Medicine, the Journal of the American College of Surgeons, the Journal of Urology, BMC Urology, Urology, and Current Opinion in Urology.

Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, and the Gold Cystoscope Award for advances in his field. Dr. Atala was named by Scientific American as a Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue and organ regeneration. In 2006, he was named by Fast Company magazine as one of 50 people who “will change how we work and live over the next 10 years. Dr. Atala’s work was listed as Discover Magazine`s Number 1 Top Science Story of the Year in the field of medicine, and as Time Magazine’s top 10 medical breakthroughs of the year in 2007. A Time Magazine poll ranked Dr. Atala as the 56th most influential person of the year in 2007. Esquire Magazine in 2008 named Dr. Atala one of the 75 most influential persons of the 21st century. Fast Company Magazine named Dr. Atala one of 100 Most Creative People in Business in 2009. Dr. Atala was featured in U.S. News & World Report as one of “14 Medical Pioneers Who Aren’t Holding Back.”

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, and the National Institutes of Health Bioengineering Consortium. He is currently an NIH “Quantum Grant” awardee. Dr. Atala heads a team of over 250 physicians and researchers. Ten applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is the editor of nine books, including Minimally Invasive Urology, Methods of Tissue Engineering, Principles of Regenerative Medicine, and Foundations of Regenerative Medicine, and has published more than 300 journal articles and has applied for or received over 200 national and international patents.

Affiliations and Expertise

Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Robert Lanza

Robert Lanza
Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.

Affiliations and Expertise

Astellas Institute for Regenerative Medicine, Westborough, MA, USA

James Thomson

Affiliations and Expertise

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

Robert Nerem

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