Principles of Nutrigenetics and Nutrigenomics - 1st Edition - ISBN: 9780128045725

Principles of Nutrigenetics and Nutrigenomics

1st Edition

Fundamentals of Individualized Nutrition

Editors: Raffaele De Caterina Alfredo Martinez Martin Kohlmeier
Hardcover ISBN: 9780128045725
Imprint: Academic Press
Published Date: 1st September 2019
Page Count: 736
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Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice.

With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields.

Key Features

  • Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics
  • Includes a valuable guide to ethics for genetic testing for nutritional advice
  • Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts
  • Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book


Researchers and students studying nutrition, genetics, genomics, personalized nutrition; clinicians including physicians, dieticians; food scientists and supplement pioneering personalized functional food and nutraceuticals product development

Table of Contents

  Catherina Geissler

  Raffaele De Caterina, J. Alfredo Martinez and Martin Kohlmeier

Section 1: The biological basis of heritability and diversity
1. The nature of traits, genes & variation
  José Luis, Vizmanos, Nick Cross and Francisco J. Novo
2. Molecular biology of genetic variants
  Martin Kohlmeier
3. Regulation of Gene Expression
  Maria L. Bonet and Andreu Palou
4. The role of nutrition in DNA replication, DNA damage prevention and DNA repair
  Michael Fenech
5. Genotyping and sequencing
  Xabier Aguirre and others
6. RNA analyses
  Ángel Gil, Francisco Javier Ruiz-Ojeda Sr. and Julio Plaza Díaz
7. Methods in Nutrigenomics for precision nutrition
  Adela Chirita-Emandi and Mihai Niculescu
8. Epigenetics: Methodology and tools for nutrition research
  María Luisa Mansego, J. Alfredo Martínez and Fermín I. Milagro
9. Proteomic analyses
  Fernando J. Corrales & Leticia Odriozola
10. Metabolomic analyses
  Susan Sumner
11. Metagenomics
  Isabel Moreno-Indias and Francisco José Tinahones
12. A Broader View on Omics and Systems Biology
  Cristina Andres-Lacueva and others
13. Study design in genomic epidemiology
  Jose L. Santos and Fernando Rivadenerira
14. Epistemology of nutrigenetic knowledge
  Martin Kohlmeier

Section 2: Nutrigenetics
15. Nutrigenetics and the early life origins of health and disease: effects of protein restriction
  Simon Langley-Evans
16. Perinatal nutrition
  Paul Cordero Sánchez, M Vinciguerra and Jude Oben
17. Epigenetics Mechanisms
  Sang Woon Choi and Lara K. Hyde
18. Genetics of Chrononutrition
  Marta Garaulet
19. Newborn screening
  Adela Chirita-Emandi
20. Genomics of Eating Behavior and Appetite Regulation
  Nanette I. Steinle
21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness
  Jose L. Santos and Victor Cortés
22. Genetic regulation of energy homeostasis: obesity implications
  Itziar Abete, Navas-Carretero, Zulet MA and Martínez JA
23. Genetic variations in the response to weight-loss diets
  Daniel A. de Luis, Aller R, Izaola O, Martínez JA
24. Genetic variations in the response to exercise: impact on physical fitness and performance
  Louis Perusse
25. Genetic variations impacting the response to defined diets
  Tiange Wang and Lu Qi
26. Carbohydrates
  Ana Ramírez de Molina and Clara Ibáñez
27. Monounsaturated and Saturated Fatty Acids
  Jose M. Ordovás
28. Omega-3 and omega-6 fatty acids
  William S. Harris
29. Blood cholesterol
  Peter Jones
30. Genetic Individuality and Alcoholic Consumption
  Rosa M. Lamuela-Raventós, Ramón Estruch Riba and Richard Kirwan
31. Vitamin A and other carotenoids
  Johannes von Lintig and Darwin Babino
32. Vitamin D
  Karina Fischer
33. Vitamin E
  Patrick Borel, Charles Desmarchelier
34. Vitamin K
  Jörg Saupe
35. Vitamins as Cofactors for Energy Homeostasis: Biotin, Thiamine and Pantothenic Acid
  Antonio Velázquez-Arellano and Alain de J. Hernández-Vázquez
36. Vitamin C
  Martin Kohlmeier
37. Vitamin B2
  Annet M. Bosch
38. Niacin
 George Rasti, Nicolas G. Simonet and Alejandro Vaquero
39. Folate, vitamin B6, vitamin B12
  Natalia Krupenko
40. Choline
  Steven H. Zeisel
41. Electrolytes
  Olivia Dong
42. Iron
  Martin Kohlmeier
43. Trace elements
  Martin Kohlmeier
44. Polyphenols and Nutrigenetic/Nutrigenomic Associations with Obesity-Related Metabolic Diseases
  Myung-Sook Choi and Eun-Young Kwon
45. Caffeine
  Raffaele De Caterina
46. Phytanic acid
  Ronald J.A. Wanders
47. Cognitive function
  Carol L. Cheatham
48. Cardiovascular Disease
  Raffaele De Caterina and Rosalinda Madonna
49. Hemostasis and thrombosis
  Antonio Capurso and Cristiano Capurso
50. Diabetes mellitus
  Helen M. Roche
51. Bone health
  José-Luis Pérez-Castrillón and Jose A. Riancho
52. Nutrients and Genes in the Liver
  Marice Cariello, Eleno Piccinin, Oihane García-Irigoyen and Antonio Moschetta
53. Hyperuricemia and gout
  Venkata Saroja Voruganti and Geetha Chittoor
54. Aging
  Deyang Yu, Luigi Fontana and D.W Lamming
55. Epigenetics in food allergies: the missing piece of the puzzle
  Shimrit Bar-El and Ram Reifen
56. Gut microbiota and their influence on the response to foods
  Yolanda Sanz, Kevin Portune and Alfonso Benítez-Páez

Section 3: Nutrigenomics
57. Nutrients and Gene Expression in Development
  Dolores Busso, Nicolas Santander, Francisca Salas and Jose L. Santos
58. Nutrients and gene expression in Obesity
  Fermín I. Milagro, Moreno-Aliaga MJ and Martínez JA
59. Nutrients and gene expression in Diabetes
  Dominique Langin
60. Gene expression in dyslipidemias
  Rui Curi and Catia Lira Amaral
61. Nutrients and gene expression in Inflammation
  Charles N. Serhan
62. Nutrients and gene expression in Cardiovascular Disease
  Raffaele De Caterina
63. Nutrients and Gene Expression in Cancer
  Ana B. Crujeiras and David de Lorenzo
64. Nutrients and Gene Expression Affecting Bone Metabolism
  José-Luis Pérez-Castrillón and others

Section 4: Translational nutrigenetics and nutrigenomics
65. Nutrigenetics-based intervention studies
  Rodrigo San-Cristóbal, Santiago Navas-Carretero, Martin Kohlmeier and J. Alfredo Martínez
66. Genome-based nutrition guidance
  Martin Kohlmeier
67. Nutrigenomics of food pesticides
  Rosita Gabbianelli and Laura Bordoni
68. Pharmaconutrigenetics: the impact of genetics on nutrient-drug interactions
  Olivia Dong and Tim Wiltshire
69. Setting genome-directed guidelines and algorithms
  Martin Kohlmeier
70. Direct-to-consumer services
  Lynnette Ferguson
71. Privacy risks and protective measures
  Francesco Visioli
72. Ethical considerations in nutrigenetics and nutrigenomics
  Ulf Gorman
73. Impact of Nutrigenetics and Nutrigenomics on Society
  Artemis Simopoulous


No. of pages:
© Academic Press 2020
Academic Press
Hardcover ISBN:

About the Editor

Raffaele De Caterina

Raffaele De Caterina, MD, PhD, FESC, is a professor of cardiology and director of University Cardiology Division at the G. d'Annunzio University, Chieti, Italy. He is also a consultant and scientific advisor for the Fondazione “G. Monasterio”, Pisa, Italy, and director of the Section of Experimental Cardiology, Center of Excellence on Aging, “G. d’Annunzio” University. He has served as president of the International Society on Nutrigenetics/Nutrigenomics (ISNN) and vice-president of the European Society of Cardiology (2008-2010). He has been editor-in-chief of the journal Vascular Pharmacology since January 2011 and has published over 490 peer-reviewed manuscripts, over 150 book chapters, and 12 books. Professor De Caterina’s current research interests include nutrigenetics and nutrigenomics, thrombosis, atherosclerosis, cardiovascular pharmacology, atrial fibrillation, and pathogenesis of coronary artery disease.

Affiliations and Expertise

University Cardiology Division, G. d’Annunzio University, Chieti, Italy

Alfredo Martinez

Alfredo Martinez, MD, PhD, is a professor of nutrition at the University of Navarra in Pamplona, Spain, where he is the head of the Department of Physiology and Nutrition. He is the current president of the International Society on Nutrigenetics/Nutrigenomics (ISNN) and president-elect of the International Union of Nutritional Sciences. He has published over 620 peer-reviewed papers and serves on the editorial boards of Nutritional Neurosciences, Annals of Nutrition and Metabolism, Nutrition, European Journal of Nutrition, Nutrition and Metabolism, Current Food and Nutrition, and the Journal of Nutrigenetics and Nutrigenomics. His research interests include nutritional and hormonal control in obesity and associated complications, nutritional utilization of functional foods, evaluation of nutritional status in different populations, nutritional/clinical interactions between nutrition and genetics, and nutritionally-oriented epidemiological surveys.

Affiliations and Expertise

Department of Nutrition, University of Navarra, Pamplona, Spain

Martin Kohlmeier

Martin Kohlmeier

Martin Kohlmeier, MD, PhD is a professor at the University of North Carolina at Chapel Hill, is director of the Nutrition in Medicine project, and heads the Nutrigenetics laboratory at the UNC Nutrition Research Institute. His nutrition research has focused on the importance of inherited variation as a modulator of nutrient disposition and on the assessment of nutritional status of normal populations and its impact on health. He has identified low endogenous cholesterol synthesis as a cause of increased cholesterol sensitivity, the apolipoprotein E polymorphism as the main genetic modulator of vitamin K status, lactase persistence as a modulator of phytoestrogen bioavailability, and a very common MTHFD1 variant as a predictor of choline requirements. He has developed online tools that provide genotype-specific personalized nutrition guidance without revealing genetic information.

Affiliations and Expertise

Department of Nutrition, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, NC, USA

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