Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure

2nd Edition - October 14, 2021

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  • Authors: Stephen Neidle, Mark Sanderson
  • Paperback ISBN: 9780128196779
  • eBook ISBN: 9780128196786

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Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA).This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.

Key Features

  • Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge
  • Defines technical terms for novices
  • Includes a complete list of resources, including relevant online databases and software, as well as useful websites


Researchers in structural and molecular biology, biochemistry and drug discovery, chemistry, chemical biology, as well as advanced undergraduate and graduate students studying nucleic acid structure and function

Table of Contents

  • 1. Methods for Studying Nucleic Acid Structure
    2. The Building-Blocks of DNA and RNA
    3. DNA Structure as Observed in Fibers and Crystals
    4. Non-standard and Higher-Order DNA Structures: DNA–DNA Recognition
    5. Principles of Small Molecule–DNA Recognition
    6. RNA Structures and Their Diversity
    7. Principles of Protein–DNA Recognition
    8. RNA Binding Proteins

Product details

  • No. of pages: 454
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: October 14, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128196779
  • eBook ISBN: 9780128196786

About the Authors

Stephen Neidle

Stephen Neidle
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Affiliations and Expertise

Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UK

Mark Sanderson

Mark Sanderson is a Visiting Professor of Biophysics in the Dept of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London. Recent structural studies in his laboratory have centred on type-II topoisomerase–DNA–drug complexes in collaboration with Prof. Mark Fisher’s group at St. George’s University of London using cryo-EM and X-ray crystallography, and the study of novel nucleic acid–protein complexes.

Affiliations and Expertise

Visiting Professor, Faculty of Medicine, Imperial College London, UK

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