Principles of Molecular Virology

Principles of Molecular Virology

6th Edition - March 5, 2015

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  • Author: Alan J. Cann
  • eBook ISBN: 9780128019559
  • Paperback ISBN: 9780128019467

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Principles of Molecular Virology, Sixth Edition, provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. This fully updated edition explores and explains the fundamental aspects of virology, including the structure of virus particles and genome, replication, gene expression, infection, pathogenesis and subviral agents. In addition, this update reflects advances made in the field, including HIV pathogenesis, cryoelectron microscopy, bioinformatics, and RNA interference.

Key Features

  • Provides a conceptual approach to the principles of molecular virology, with important examples of new advances in virology
  • Includes online resources for students and instructors
  • New concepts in this edition include coverage of newly discovered and emergent viruses such as MERS and Ebola
  • Presents new and updated information on bioinformatics and metagenomics
  • Contains updated learning outcomes and further reading for each chapter


Students and professors in virology, molecular biology and microbiology; researchers entering virology, infectious disease, and immunology research.

Table of Contents

    • Preface to the Sixth Edition
      • Reference
    • Chapter 1. Introduction
      • Intended Learning Outcomes
      • What Are Viruses?
      • Are Viruses Alive?
      • The History of Virology
      • Living Host Systems
      • Cell Culture Methods
      • Serological/Immunological Methods
      • Ultrastructural Studies
      • Molecular Biology
      • Further Reading
    • Chapter 2. Particles
      • Intended Learning Outcomes
      • The Function and Formation of Virus Particles
      • Capsid Symmetry and Virus Architecture
      • Helical Capsids
      • Icosahedral (Isometric) Capsids
      • Enveloped Viruses
      • Complex Virus Structures
      • Protein–Nucleic Acid Interactions and Genome Packaging
      • Virus Receptors: Recognition and Binding
      • Other Interactions of the Virus Capsid with the Host Cell
      • Summary
      • Further Reading
    • Chapter 3. Genomes
      • Intended Learning Outcomes
      • The Structure and Complexity of Virus Genomes
      • Molecular Genetics
      • Virus Genetics
      • Virus Mutants
      • Genetic Interactions between Viruses
      • Nongenetic Interactions between Viruses
      • Small DNA Genomes
      • Large DNA Genomes
      • Positive-Strand RNA Viruses
      • Negative-Strand RNA Viruses
      • Segmented and Multipartite Virus Genomes
      • Reverse Transcription and Transposition
      • The Virome—Evolution and Epidemiology
      • Summary
      • Further Reading
    • Chapter 4. Replication
      • Intended Learning Outcomes
      • Overview of Virus Replication
      • Investigation of Virus Replication
      • The Replication Cycle
      • Summary
      • Further Reading
    • Chapter 5. Expression
      • Intended Learning Outcomes
      • Expression of Genetic Information
      • Control of Prokaryote Gene Expression
      • Control of Expression in Bacteriophage λ
      • Control of Eukaryote Gene Expression
      • Genome Coding Strategies
      • Transcriptional Control of Expression
      • Posttranscriptional Control of Expression
      • Summary
      • Further Reading
    • Chapter 6. Infection
      • Intended Learning Outcomes
      • Virus Infections of Plants
      • Immune Responses to Virus Infections in Animals
      • Viruses and Apoptosis
      • Interferons
      • Evasion of Immune Responses by Viruses
      • Virus–Host Interactions
      • The Course of Virus Infections
      • Prevention and Therapy of Virus Infection
      • RNA Interference
      • Viruses as Therapeutics
      • Chemotherapy of Virus Infections
      • Summary
      • Further Reading
    • Chapter 7. Pathogenesis
      • Intended Learning Outcomes
      • Mechanisms of Cellular Injury
      • Viruses and Immunodeficiency
      • Virus-Related Diseases
      • Bacteriophages and Human Disease
      • Cell Transformation by Viruses
      • Cell Transformation by Retroviruses
      • Cell Transformation by DNA Viruses
      • Viruses and Cancer
      • New and Emergent Viruses
      • Zoonoses
      • Bioterrorism
      • Summary
      • Further Reading
    • Chapter 8. Subviral Agents: Genomes without Viruses, Viruses without Genomes
      • Intended Learning Outcomes
      • Satellites and Viroids
      • Prions
      • Pathology of Prion Diseases
      • TSE in Animals
      • Human TSEs
      • Molecular Biology of Prions
      • Summary
      • Further Reading
    • Appendix 1. Glossary and Abbreviations
    • Appendix 2. Classification of Subcellular Infectious Agents
    • Appendix 3. The History of Virology
    • Index

Product details

  • No. of pages: 318
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: March 5, 2015
  • Imprint: Academic Press
  • eBook ISBN: 9780128019559
  • Paperback ISBN: 9780128019467

About the Author

Alan J. Cann

Alan J. Cann
Dr. Alan J. Cann has worked in both the U.K. and U.S.A. teaching undergraduate, postgraduate, and medical students. He is currently a Senior Lecturer in Biological Sciences at the University of Leicester where his research interests include pedagogic research and science communication.

Affiliations and Expertise

Senior Lecturer, Department of Microbiology and Immunology, University of Leicester, UK

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