Principles of Molecular Virology - 6th Edition - ISBN: 9780128019467, 9780128019559

Principles of Molecular Virology

6th Edition

Paperback ISBN: 9780128019467
eBook ISBN: 9780128019559
Imprint: Academic Press
Published Date: 5th March 2015
Page Count: 318
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Principles of Molecular Virology, Sixth Edition, provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner.

This fully updated edition explores and explains the fundamental aspects of virology, including the structure of virus particles and genome, replication, gene expression, infection, pathogenesis and subviral agents.

In addition, this update reflects advances made in the field, including HIV pathogenesis, cryoelectron microscopy, bioinformatics, and RNA interference.

Key Features

  • Provides a conceptual approach to the principles of molecular virology, with important examples of new advances in virology
  • Includes online resources for students and instructors
  • New concepts in this edition include coverage of newly discovered and emergent viruses such as MERS and Ebola
  • Presents new and updated information on bioinformatics and metagenomics
  • Contains updated learning outcomes and further reading for each chapter


Students and professors in virology, molecular biology and microbiology; researchers entering virology, infectious disease, and immunology research.

Table of Contents

  • Preface to the Sixth Edition

    • Reference
  • Chapter 1. Introduction

    • Intended Learning Outcomes
    • What Are Viruses?
    • Are Viruses Alive?
    • The History of Virology
    • Living Host Systems
    • Cell Culture Methods
    • Serological/Immunological Methods
    • Ultrastructural Studies
    • Molecular Biology
    • Further Reading
  • Chapter 2. Particles

    • Intended Learning Outcomes
    • The Function and Formation of Virus Particles
    • Capsid Symmetry and Virus Architecture
    • Helical Capsids
    • Icosahedral (Isometric) Capsids
    • Enveloped Viruses
    • Complex Virus Structures
    • Protein–Nucleic Acid Interactions and Genome Packaging
    • Virus Receptors: Recognition and Binding
    • Other Interactions of the Virus Capsid with the Host Cell
    • Summary
    • Further Reading
  • Chapter 3. Genomes

    • Intended Learning Outcomes
    • The Structure and Complexity of Virus Genomes
    • Molecular Genetics
    • Virus Genetics
    • Virus Mutants
    • Genetic Interactions between Viruses
    • Nongenetic Interactions between Viruses
    • Small DNA Genomes
    • Large DNA Genomes
    • Positive-Strand RNA Viruses
    • Negative-Strand RNA Viruses
    • Segmented and Multipartite Virus Genomes
    • Reverse Transcription and Transposition
    • The Virome—Evolution and Epidemiology
    • Summary
    • Further Reading
  • Chapter 4. Replication

    • Intended Learning Outcomes
    • Overview of Virus Replication
    • Investigation of Virus Replication
    • The Replication Cycle
    • Summary
    • Further Reading
  • Chapter 5. Expression

    • Intended Learning Outcomes
    • Expression of Genetic Information
    • Control of Prokaryote Gene Expression
    • Control of Expre


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© Academic Press 2016
Academic Press
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