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Principles of Hormone/Behavior Relations - 2nd Edition - ISBN: 9780128026298, 9780128026670

Principles of Hormone/Behavior Relations

2nd Edition

Authors: Donald W Pfaff Robert Rubin Jill Schneider Geoff Head
Paperback ISBN: 9780128113714
eBook ISBN: 9780128026670
Imprint: Academic Press
Published Date: 10th January 2018
Page Count: 572
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Principles of Hormone/Behavior Relations, Second Edition, provides an introduction to the underlying principles of endocrine regulation of behavior, a newly emerging area of research within neurobiology and endocrinology. It addresses the properties of hormone/behavior relations, including the influence of family background, timing issues, neuroanatomical features, cellular mechanisms, and the importance of environmental context and evolution. This new edition incorporates critical advances in the field, also including increased coverage of hormonal influences on food intake, and on the cardiovascular system.

The addition of entirely new principles provides further coverage of epigenetics and appetite. Thoroughly revised and updated, this book is an ideal resource for neuroscientists and researchers engaging in this rapidly expanding field of study.

Key Features

  • Provides a unique structure where each chapter addresses a key principle that is illustrated by numerous basic experimental and clinical examples
  • Includes user-friendly features, such as boxed figures with extended captions and references, numerous clinical notes, and a comprehensive list of abbreviations
  • Contains numerous illustrations that highlight both the clinical and basic science information


Neuroscientists and endocrinologists, as well as advanced students

Table of Contents

Section I: Characterizing the Phenomena: Hormone Effects are Strong and Reliable
1. Hormones Can Both Facilitate and Repress Behavioral Responses
2. One Hormone Can have Many Effects: A Single Hormone Can Affect Complex Behaviors
3. Hormone Combinations Can be Important for Influencing an Individual Behavior
4. Hormone Metabolites Can be the Behaviorally Active Compounds
5. There are Optimal Hormone Concentrations: Too Much or Too Little Can be Damaging
6. Hormones Do Not ‘‘Cause’’ Behavior; They Alter Probabilities of Responses to Given Stimuli

Section II: History: Hormone Effects Can Depend on Family, Gender, and Development
7. Familial/Genetic Dispositions to Hormone Responsiveness Can Influence Behavior
8. The Sex of the Recipient can Influence the Behavioral Response
9. Hormone Actions Early in Development Can Influence Hormone Responsiveness in the CNS During Adulthood
10. Puberty Alters Hormone Secretion and Hormone Responsivity and Heralds Sex Differences
11. Changes in Hormone Levels and Responsiveness During Aging Affect Behavior

Section III: Time: Hormonal Effects on Behavior Depend on Temporal Parameters
12. Duration of Hormone Exposure Can Make a Big Difference: In Some Cases Longer is Better; In Other Cases Brief Pulses are Optimal for Behavioral Effects
13. Hormonal Secretions and Responses are Affected by Biological Clocks

Section IV: Space: Spatial Aspects of Hormone Administration and Impact are Important
14. Effects of a Given Hormone Can be Widespread Across the Body; Central Effects Consonant with Peripheral Effects Form Coordinated, Unified Mechanisms
15. Hormones Can Act at All Levels of the Neuraxis to Exert Behavioral Effects; The Nature of the Behavioral Effect Depends on the Site of Action

Section V: Mechanisms: Molecular and Biophysical Mechanisms of Hormone Actions Give Clues to Future Therapeutic Strategies
16. In Responsive Neurons, Rapid hormone Effects Can Facilitate Later Genomic Actions
17. Gene Duplication and Splicing Products for Hormone Receptors in the CNS Often Have Different Behavioral Effects
18. Hormone Receptors and Other Nuclear Proteins Influence Hormone Responsiveness

Section VI: Environment: Environmental Variables Influence Hormone/Behavior Relations
19. Hormone Effects on Behavior Depend Upon Context
20. Behavioral/Environmental Context also Alters Hormone Release

Section VII: Evolution
21. Neuroendocrine Mechanisms Have Been Conserved to Provide Biologically Adaptive Body/Brain/Behavior Coordination


No. of pages:
© Academic Press 2018
10th January 2018
Academic Press
Paperback ISBN:
eBook ISBN:

About the Authors

Donald W Pfaff

Donald W. Pfaff heads the Laboratory of Neurobiology and Behavior at The Rockefeller University. He received his scientific training at Harvard College and MIT. He is a Member of the U.S. National Academy of Sciences and a Fellow of the American Academy of Arts and Sciences. Pfaff's laboratory focuses on steroid hormones and brain function, genes influencing neuronal functions, and generalized CNS arousal. He is the author or coauthor of over 10 books and more than 900 research publications.

Affiliations and Expertise

Laboratory of Neurobiology and Behavior, Rockefeller University, NY, USA

Robert Rubin

VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA

Affiliations and Expertise

VA Greater Los Angeles Healthcare System, Los Angeles, CA, U.S.A

Jill Schneider

Professor Jill E. Schneider has been teaching undergraduate courses in Behavioral Endocrinology and other topics in neuroscience at Lehigh University for over 25 years. She received graduate and postdoctoral training in biology and neuroscience at Wesleyan University and the University of Massachusetts, respectively, and was awarded the Frank A. Beach Award from the Society for Behavioral Neuroendocrinology for outstanding research in behavioral neuroendocrinology in 1991. Professor Schneider’s National Science Foundation-funded neuroendocrinology laboratory is focused on metabolic and hormonal mechanisms at the interface of reproductive and ingestive behavior.

Affiliations and Expertise

Department of Biological Sciences, Lehigh University, USA

Geoff Head

Affiliations and Expertise

Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute, Australia

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