Principles of Developmental Genetics

2nd Edition

Editors: Sally Moody
Hardcover ISBN: 9780124059450
eBook ISBN: 9780124059238
Imprint: Academic Press
Published Date: 1st August 2014
Page Count: 784
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Providing expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries of major takeaways and clinical pathways assist comprehension and readability of the highly complex content.

Key Features

  • All-new coverage of systems biology and stem cell biology in context of evolving technologies places the work squarely on the modern sciences
  • Chapters are complemented with a bulleted summary for easy digestion of the major points, with a clinical summary for therapeutic application
  • Clinical highlights provides a bridge between basic developmental biology and clinical sciences in embryonic and prenatal syndromes


Basic cell and developmental biologists, developmental geneticists, stem cell biologists, clinical scientists and evo-devo biologists.

Table of Contents

  • Preface
  • <li>Section I. Emerging Technologies and Systems Biology<ul><li>Chapter 1. Generating Diversity and Specificity through Developmental Cell Signaling<ul><li>Summary</li><li>1.1. Introduction</li><li>1.2. Identification of Signaling Pathway Components</li><li>1.3. Functional Diversification of Related Signaling Proteins</li><li>1.4. Roles of Cytoplasmic Extensions in Cell Signaling</li><li>1.5. Formation and Interpretation of Signaling Gradients</li><li>1.6. Transcriptional Regulation by Developmental Cell Signaling Pathways</li><li>1.7. Transcription-Independent Responses to Cell Signaling</li><li>1.8. Roles of Computational Biology in Developmental Cell Signaling Studies</li><li>1.9. Closing Remarks</li><li>1.10. Clinical Relevance: Developmental Cell Signaling and Human Disease</li></ul></li><li>Chapter 2. Applications of Deep Sequencing to Developmental Systems<ul><li>Summary</li><li>2.1. Introduction</li><li>2.2. Using RNA-seq to Map and Quantify Transcripts</li><li>2.3. Chromatin Immunoprecipitation for Identifying Protein-DNA Interactions</li><li>2.4. DNAse I Hypersensitive Site Mapping to Identify Cis-Regulatory Regions</li><li>2.5. Interactions at a Distance</li><li>2.6. Prospects</li><li>2.7. Clinical Relevance</li></ul></li><li>Chapter 3. Using Mutagenesis in Mice for Developmental Gene Discovery<ul><li>Summary</li><li>3.1. Use of ENU as a Mutagen</li><li>3.2. ENU-Induced Mutations in Mice</li><li>3.3. ENU-Induced Mutations Affecting Development</li><li>3.4. Identification of Modifier loci</li><li>3.5. Clinical Relevance</li></ul></li><li>Chapter 4. Chemical Approaches to Controlling Cell Fate<ul><li>Summary</li><li>4.1. Introduction</li><li>4.2. Chemical Approaches to Controlling Cell Fate</li><li>4.3. Clinical Relevance</li></ul></li><li>Chapter 5. BMP Signaling and Stem Cell Self-Renewal in the <i>Drosophila</i> Ovary<ul><li>Summary</li><li>5.1. Introduction</li><li>5.2. The <i>Drosophila</i> Ovary</li><li>5.3. The BMP


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About the Editor

Sally Moody

Sally A. Moody is Professor of Anatomy and Cell Biology at the George Washington University Medical Center, and a member of both the Neuroscience and Genetics programs. Prior to this appointment she was on the faculty of the Anatomy and Cell Biology Department, the Department of Neuroscience, and the Developmental Biology program at the University of Virginia. She trained in developmental neurobiology at the University of Florida’s Department of Neuroscience and the University of Utah’s Department of Neurobiology and Anatomy. Dr. Moody’s current research focuses on the cascade of interactions that instruct lineages to give rise to the frog nervous system. She has taught developmental neurobiology in the MBL "Neurobiology" course and was co-director of the "Early Development of Xenopus Laevis" course at the Cold Spring Harbor Laboratory. She has also served on many National Institute of Health advisory committees dealing with issues in developmental biology and developmental neurobiology, and served on the Board of Trustees of the Society for Developmental Biology.

Affiliations and Expertise

George Washington University, Washington, DC, USA


" coverage of all major events in early embryogenesis and the organogenesis of specific systems, supplemented with representative clinical syndromes." --Anticancer Research