Principles of Animal Research for Graduate and Undergraduate Students

Principles of Animal Research for Graduate and Undergraduate Students

1st Edition - November 16, 2016

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  • Authors: Mark Suckow, Kay Stewart
  • Paperback ISBN: 9780128021514
  • eBook ISBN: 9780128023662

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Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher’s education.

Key Features

  • Provides background material for students to understand the broader backdrop against which animal research is undertaken
  • Includes ethical and regulatory information
  • Covers commonly used animal models and the process to choose a model for biomedical research


Early researchers, undergraduate and graduate students, researchers and professors studying laboratory animal research; technicians in laboratory animal science; pre-veterinarians and veterinarians; and students/early researchers working with laboratory animals across biological and biomedical research

Table of Contents

    • Preface
    • Chapter 1. Brief Historical Overview on the Use of Animals in Research
      • 1.1. Introduction
      • 1.2. Early Attitudes Toward Animal Health and Disease
      • 1.3. Development and Emergence of New Animal Models
      • 1.4. Improvements in Approaches to Animal Care
      • 1.5. Summary
    • Chapter 2. Philosophical and Ethical Foundations
      • 2.1. Basic Approaches
      • 2.2. Animal Welfare Versus Animal Rights
      • 2.3. Opposition to and Benefits of Animal Experimentation
      • 2.4. Professional Ethics Relating to Biomedical Research
    • Chapter 3. Regulations and Guidelines
      • 3.1. Introduction
      • 3.2. US Animal Welfare Act
      • 3.3. Public Health Service Policy
      • 3.4. FDA Good Laboratory Practices
      • 3.5. Other Laws, Regulations, and Policies
      • 3.6. Fish and Wildlife Service and NIH Positions on Chimpanzees
      • 3.7. Professional and Scientific Associations
      • 3.8. International Laws and Regulations
      • 3.9. Conclusions
    • Chapter 4. Institutional Animal Care and Use Committee
      • 4.1. Purpose and Function
      • 4.2. Committee Composition
      • 4.3. IACUC Review of Proposed Activities and Projects
      • 4.4. Periodic Review of the Animal Care and Use Program and Facilities
      • 4.5. Investigation of Concerns Regarding the Use and Treatment of Vertebrate Animals
      • 4.6. Sample Size Estimation in Laboratory Animal Experiments
    • Chapter 5. Experimental Variables
      • 5.1. The Research Environment
      • 5.2. Environmental Enrichment
      • 5.3. Animal Health Monitoring Program
      • 5.4. Summary
    • Chapter 6. Model Selection
      • 6.1. Selection Criteria
      • 6.2. Types of Models
      • 6.3. Spontaneous Mutation Models
      • 6.4. Random Mutation Models
      • 6.5. Genetically Manipulated Models
      • 6.6. Chemically Induced Models
      • 6.7. Physically Induced Models
      • 6.8. Surgical Models
      • 6.9. Behavioral Models
      • 6.10. Production Models
    • Chapter 7. Commonly Used Animal Models
      • 7.1. The Mouse
      • 7.2. The Rat
      • 7.3. The Rabbit
      • 7.4. Zebrafish
      • 7.5. Amphibians and Reptiles
      • 7.6. Birds
      • 7.7. Other Small Mammals
      • 7.8. Summary
    • Chapter 8. Common Technical Procedures in Rodents
      • 8.1. Handling and Restraint Methods
      • 8.2. Identification
      • 8.3. Common Technical Procedures
      • 8.4. Rodent Anesthesia
      • 8.5. Rodent Surgery
      • 8.6. Euthanasia
      • 8.7. Necropsy
      • 8.8. Summary
    • Chapter 9. Considerations for Use of Vertebrates in Field Studies
      • 9.1. Reasons for Conducting Field Research
      • 9.2. Sources for Specific Technique Information
      • 9.3. Initial Steps for Undertaking Field Research Involving Vertebrates
      • 9.4. Observational Techniques
      • 9.5. Capturing Animals
      • 9.6. Handling Animals
      • 9.7. Identification and Marking of Animals
      • 9.8. Conclusion
    • Chapter 10. Personnel Safety in the Care and Use of Laboratory Animals
      • 10.1. Introduction
      • 10.2. Occupational Health and Safety Programs
      • 10.3. Hazards Associated With Animal Research
      • 10.4. Best Practices for Prevention
      • 10.5. Conclusions: Personnel Engagement and Awareness
    • Chapter 11. Thesis Development
      • 11.1. Preparation
      • 11.2. Thesis Sections
      • 11.3. Finalizing the Thesis
      • 11.4. Conclusion
    • Glossary of Terms and Acronyms
    • Index

Product details

  • No. of pages: 286
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: November 16, 2016
  • Imprint: Academic Press
  • Paperback ISBN: 9780128021514
  • eBook ISBN: 9780128023662

About the Authors

Mark Suckow

Mark Suckow received his DVM from the University of Wisconsin in 1987 and subsequently completed a post-doctoral residency in laboratory animal medicine at the University of Michigan in 1990. He spent 8 years as a clinical laboratory animal veterinarian at Purdue University and then 17 years at the University of Notre Dame where he served as Director of the Freimann Life Science Center and later as Associate Vice President for Research Compliance. Prior to coming to the University of Kentucky, he was Professor of Veterinary Population Medicine and Director, Research Animal Resources at the University of Minnesota. With an interest in cancer models, biomaterials models, and vaccines, Dr. Suckow has functioned as an independent and collaborative investigator and has published in refereed journals and has seven issued patents related to vaccine adjuvants and cancer vaccines. He has written or edited over 20 books on topics related to research and laboratory animal medicine. Further, he served as the 2006 President of the American Association for Laboratory Animal Science and the 2011 President of the American Society of Laboratory Animal Practitioners; and currently he serves on the AVMA Council on Research and is a member of the Council on Accreditation of AAALAC, International.

Affiliations and Expertise

Associate Vice President for Research, Attending Veterinarian, University of Kentucky, USA.

Kay Stewart

Kay Stewart is the Associate Director of the Freimann Life Science Centre at the University of Notre Dame. Her research straddles both the role of animals in biomedical research and the ethics and treatment of animals in academic settings.

Affiliations and Expertise

Associate Director of Freimann Life Science Center, University of Notre Dame, Notre Dame, IN, USA

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