Precision Medicine and the Reinvention of Human Disease - 1st Edition - ISBN: 9780128143933

Precision Medicine and the Reinvention of Human Disease

1st Edition

Authors: Jules Berman
Paperback ISBN: 9780128143933
Imprint: Academic Press
Published Date: 2nd April 2018
Page Count: 400
Tax/VAT will be calculated at check-out Price includes VAT (GST)

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Precision Medicine and the Reinvention of Human Disease clarifies the foundational concepts of precision medicine, distinguishing this field from its early predecessors such as genomics, pharmacogenomics, and personalized medicine. Until recently, most of medicine was focused either on the beginning of diseases or the end-point of them. With precision medicine, attention has shifted to the precise steps of disease development. In particular, biomedical scientists are now looking for the key genetic and cellular pathways that lead to the emergence of a disease. Thus, precision medicine is reinventing disease in terms events and pathways that will serve as targets for new preventive, diagnostic, and therapeutic interventions.

This book discusses topics such as disease causality, genetics, diseases convergence and how to diagnose using precision medicine. Additionally, it is discussed the importance of data management and its impact on the future of this exciting field.

The book is a valuable source for bioinformaticians, computer biologists, geneticists and several members of biomedical field who are interested in learning more about this new and very fundable field of precision medicine.

Key Features

  • Clarifies the foundational concepts of precision medicine, distinguishing this field from its early predecessors such as genomics, pharmacogenomics, and personalized medicine
  • Explains the interdisciplinary field of precision medicine in plain language, in order to be accessible to anyone who has taken a college level biology course
  • Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way
  • Discusses the important role of proper methods for data collection, data annotation, and data sharing in precision medicine, and the many data-related challenges that confront this fragile new field

Readership

Bioinformaticians, graduate students on bioinformatics and genetics, researchers from several biomedical areas

Table of Contents

Chapter 1. Introduction: Seriously, What is Precision Medicine?

Chapter 2. Redefining Disease Causality

Causality and Its Paradoxes

Why We Are Confident that Diseases Develop in Steps?

Cause of Death

What Is a Disease Pathway?

Multiple Steps Lead Us to Multiple Treatment Opportunities

Does Single Event Pathogenesis Ever Happen, and Should We Care?

Chapter 3. Genetics: Clues, Not Answers, to the Mysteries of Precision Medicine

Inscrutable Disease Genes

Discovering the Complex Mechanisms of Genetic Diseases

Epigenomic Diseases

Why a Gene-based Disease Classification Is a Bad Idea

Chapter 4. Disease Convergence

Convergence in Precision Medicine

Phenocopy Diseases: Convergence Without Mutation

The Autoimmune Phenocopies

Pathways that Converge to Common Diseases

Common Treatments for Convergent Diseases

Chapter 5. The Precision of the Rare Diseases

The Biological Differences Between Rare Diseases and Common Diseases

Why Rare Diseases Are Precisely Understood; and Common Diseases Are Not

Precision Medicine's First Benefit: Cures for Rare Diseases

What the Rare Diseases Tell Us About the Common Diseases

Treatments for Rare Diseases are Effective Against the Common Diseases

Chapter 6. Precision Organisms

Modern Taxonomy of Infectious Diseases

Our Genome Is a Book Titled "The History of Human Infections"

Revising Koch's Postulates for Precision Medicine

Inflammatory Diseases: Collateral Damage in the War on Human Infection

Precision Taxonomy

Chapter 7. Reinventing Diagnosis

Precision Medicine Mandates a New Classification of Disease

The Horrible Consequences of Imprecise Diagnoses

The Principles of Classification

Classifications Cannot Be Based on Similarities

Subclassifying and Superclassifying Diseases

Diseases-in-waiting

What Is Precision Diagnosis?

Chapter 8. Precision Data

What Are the Minimal Necessary Properties of Good Data?

Identification and Time-stamping: Indispensable keys to Precision Data

What Do We Do With Non-quantitative, Descriptive Data?

Incredibly Simple Methods to Understand Precision Data

Data Reanalysis: More important than the Original Data Analysis

What Is Data Sharing, and Why Don't We Do More of It?

Chapter 9. Impersonalized Precision Medicine

The Myth of Personalized Medicine

Pharmacogenomics: A Bridge Too Far

Reinventing Clinical Trials

Impersonalized Medical Care; Searching for a Panacea

Chapter 10. The Alternate Futures of Precision Medicine

Hypersurveillance model

Do It Yourself Model

Eugenics Model

Public Health Model

Data Analytics Model

Global Biome Model

Animal Experimentation: New Opportunities, New Limits

Details

No. of pages:
400
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128143933

About the Author

Jules Berman

Jules Berman

Jules Berman holds two bachelor of science degrees from MIT (Mathematics, and Earth and Planetary Sciences), a PhD from Temple University, and an MD, from the University of Miami. He was a graduate researcher in the Fels Cancer Research Institute, at Temple University, and at the American Health Foundation in Valhalla, New York. His post-doctoral studies were completed at the U.S. National Institutes of Health, and his residency was completed at the George Washington University Medical Center in Washington, D.C. Dr. Berman served as Chief of Anatomic Pathology, Surgical Pathology and Cytopathology at the Veterans Administration Medical Center in Baltimore, Maryland, where he held joint appointments at the University of Maryland Medical Center and at the Johns Hopkins Medical Institutions. In 1998, he transferred to the U.S. National Institutes of Health, as a Medical Officer, and as the Program Director for Pathology Informatics in the Cancer Diagnosis Program at the National Cancer Institute. Dr. Berman is a past President of the Association for Pathology Informatics, and the 2011 recipient of the association's Lifetime Achievement Award. He is a listed author on over 200 scientific publications and has written more than a dozen books in his three areas of expertise: informatics, computer programming, and cancer biology. Dr. Berman is currently a free-lance writer.

Affiliations and Expertise

Ph.D., M.D., freelance author with expertise in informatics, computer programming, and cancer biology