Practical Biostatistics

Practical Biostatistics

A Friendly Step-by-Step Approach for Evidence-based Medicine

1st Edition - July 26, 2012

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  • Authors: Mendel Suchmacher, Mauro Geller
  • Paperback ISBN: 9780124157941
  • eBook ISBN: 9780124158573

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Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. Practical Biostatistics provides researchers, medical professionals, and students with a friendly, practical guide to biostatistics. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials.

Key Features

  • Customized presentation for biological investigators with examples taken from current clinical trials in multiple disciplines
  • Clear and concise definitions and examples provide a pragmatic guide to bring clarity to the applications of statistics in improving human health
  • Addresses the challenge of assimilation of mathematical concepts to better interpret literature, to build stronger studies, to present research effectively, and to improve communication with supporting biostatisticians


Investigators and clinicians involved in genetics, genomics, immunology, virology, microbiology, cell biology, pharmacology, and biomedical research; post-doctoral fellows and graduate researchers; physicians who need to make evidence-based clinical decisions; physicians and medical students who consult medical literature which demands knowledge on biostatistics; instructors and trainees in national and international technical clinician and degree programs

Table of Contents

  • Foreword



    Part I Introduction

    Chapter 1. Study Type Determination

    1.1 Epidemiological Studies

    1.2 Analytical Studies

    1.3 Summary of Study Types

    Suggested Reading

    Part II. Observational Studies

    Chapter 2. Determination of Association Strength between an Exposure Factor and an Event in Observational Studies

    2.1 Case–Control Studies

    2.2 Cohort Studies

    Chapter 3. Increasing Accuracy in Observational Studies

    3.1 Stratified Analysis

    3.2 Multivariable Analysis

    Suggested Reading

    Part III. Step-by-Step Biostatistics of a Clinical Trial

    Chapter 4. Step 1: Investigator’s Hypothesis and Expression of its Corresponding Outcome

    Chapter 5. Step 2: Estimation and Assessment of a Published Trial

    5.1 Factors Influencing n Determination

    5.2 n Calculation

    5.3 Assessing n of a Published Trial

    Chapter 6. Step 3: Organization of Variables and Endpoints

    6.1 Qualitative Variables

    6.2 Quantitative Variables

    Chapter 7. Step 4: Measures for Results Expression of a Clinical Trial

    7.1 Central Tendency Measures

    7.2 Dispersal Measures

    7.3 Position Measures: Quantiles

    Appendix 7.1 How to Calculate Mean Using Microsoft Excel (Section 7.1.1)

    Appendix 7.2 How to “Trim” The Mean of Outliers (Section 7.1.1)

    Appendix 7.3 How to Determine Median Using Microsoft Excel (Section 7.1.2)

    Appendix 7.4 How to Determine Mode Using Microsoft Excel (Section 7.1.3)

    Appendix 7.5 How to Calculate Standard Deviation Using Microsoft Excel (Section 7.2.2)

    Appendix 7.6 How to Find the Exact BMI that Corresponds to the 90th Percentile using Microsoft Excel (Section 7.3)

    Appendix 7.7 How to Put all BMIs in a “Rank and Percentile” Perspective using Microsoft Excel (Section 7.3)

    Chapter 8. Step 5: Determination of Normality or Non-Normality of Data Distribution

    Appendix 8.1 How to Verify Normality of a Graph Curve Using Microsoft Excel

    Chapter 9. Step 6: Hypothesis Testing

    9.1 Parametric Tests for Independent and Dependent Samples

    9.2 Nonparametric Tests

    Chapter 10. Step 7: Correlating Sample Data with the General Population – 95% Confidence Interval

    10.1 Point Estimation

    10.2 Interval Estimation (95% Confidence Interval)

    Appendix 10.1 How to Determine Confidence Intervals Using Microsoft Excel (Sample A)

    Suggested Reading

    Part IV. Additional Concepts in Biostatistics

    Chapter 11. Individual and Collective Benefit and Risk Indexes Inferable from Intervention Studies

    11.1 Treatment Effect Indexes

    11.2 Clinical Decision Analysis Indexes

    Chapter 12. Statistical Assessment of Diagnostic Tests for the Clinic

    12.1 Detection Capacity Indexes

    12.2 Diagnostic Significance Indexes

    Chapter 13. Systematic Reviews and Meta-Analyses

    13.1 Definitions

    13.2 Systematic Review

    13.3 Meta-Analysis

    13.4 Options if Meta-Analysis Performance is not Advisable

    13.5 Systematic Review/Meta-Analysis Limitations

    13.6 Systematic Review/Meta-Analysis Stages Summary

    13.7 Suggested Resources and Literary Sources

    Chapter 14. Correlation and Regression

    14.1 Correlation

    14.2 Regression

    14.3 Multiple Linear Regression

    Appendix 14.1 How to Build a Scatterplot and to Add a Trend Line Using Microsoft Excel

    Appendix 14.2 How to Calculate Pearson’s Correlation Coefficient Using Microsoft Excel

    Appendix 14.3 How to Predict a Dependent Variable Using Microsoft Excel

    Chapter 15. Per Protocol Analysis and Intention to Treat Analysis

    Suggested Reading

    APPENDIX. Microsoft Excel 2010 Basics

    A.1 Structure and Main Features of a Microsoft Excel 2010 Worksheet

    A.2 Location of Statistical Resources

    A.3 Building a Plain Table

    A.4 Building a Basic Chart

    A.5 Building a Chart Out of a Table

    A.6 Pivot Table

    Suggested Reading



Product details

  • No. of pages: 248
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: July 26, 2012
  • Imprint: Academic Press
  • Paperback ISBN: 9780124157941
  • eBook ISBN: 9780124158573

About the Authors

Mendel Suchmacher

Mendel Suchmacher, MD, MSc, graduated in Pharmaceutical Medicine at Federal University of the State of São Paulo, is Board Certified in Internal Medicine and Hematology-Hemotherapy and member of the American College of Physicians. He holds teaching and research positions at prestigious Brazilian institutions: Professor of Clinical Immunology at Carlos Chagas Institute of Medical Graduation; Professor & Chairman of Microbiology and Immunology, and Research Fellow at Teresopolis University Medical School - UNIFESO; Professor & Coordinator of the Genodermatoses Sector of the Clinical Genetics Service at Federal University of Rio de Janeiro. Additionally, he is member of the clinical staff of Hospital Israelita Albert Einstein.

Affiliations and Expertise

Professor of Clinical Immunology, Carlos Chagas Institute of Medical Graduation; Professor and Chairman of Microbiology and Immunology, and Research Fellow, Teresopolis University Medical School - UNIFESO; Professor and Coordinator of the Genodermatoses Sector of the Clinical Genetics Service, Federal University of Rio de Janeiro, Brazil

Mauro Geller

Mauro Geller
Mauro Geller, MD, PhD, holds an MD degree from Teresopolis University Medical School, a PhD in Clinical Medicine from Federal University of Rio de Janeiro, and a Post-doc in Immunogenetics from Harvard University. He has extensive experience in the field of clinical immunology, especially in the areas of clinical medicine, tumoral immunology, genetics and immunodiagnostics. Dr. Geller is founding member and current medical director of the Brazilian National Neurofibromatosis Center; fellow of the American College of Physicians and of the Royal Society of Medicine; member of the European Society of Gene Therapy; and member of the Brazilian Societies of Immunology, Microbiology and Genetics. He is Board Certified in Internal Medicine, Immunology, Allergy and Public Health. Dr. Geller also has extensive experience with research in the areas of immunology, microbiology and genetics, as well as with clinical research, and has published 137 papers, 8 book chapters, and 4 books. He also serves as ad hoc advisor to the Brazilian National Institute of Health (ANVISA) and is member of the clinical staff of Hospital Israelita Albert Einstein.

Affiliations and Expertise

MD degree, Teresopolis University Medical School PhD, Clinical Medicine, Federal University of Rio de Janeiro Post-doc, Immunogenetics, Harvard University

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  • Mohamed M. Wed May 18 2022

    Practical Biostatistics