Post-Genomic Cardiology

2nd Edition

Authors: José Marín-García
Hardcover ISBN: 9780124045996
eBook ISBN: 9780124046429
Imprint: Academic Press
Published Date: 4th June 2014
Page Count: 944
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Description

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach.

This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA.

Key Features

  • Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches
  • Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome
  • Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Readership

Cardiologists, geneticists, physiologists, cell and developmental biologists as well as clinicians with interests in metabolic disease, neonatal medicine and aging specialists.

Table of Contents

  • Dedication
  • Preface
  • Section I: Post-Genomic Cardiology

    • Chapter 1. Introduction to the Molecular Biology of the Cell

      • Nucleic Acids, Genes, Chromatin, and Chromosomes
      • DNA Transacting Processes: Replication, Transcription, and Repair
      • Genetic Variability Associated with Human Diseases
      • Cell Cycle
      • References
    • Chapter 2. Methodologies in the Era of Cardiovascular “Omics”

      • Introduction
      • Genomics Approaches: NGS and GWAS
      • Transcriptomics
      • Proteomics and Interactomics
      • Metabolomics
      • Cardiac Imaging
      • Translational Bioinformatics
      • Conclusions
      • Summary
      • References
    • Chapter 3. Post-Genomics Cardiovascular Signaling Pathways

      • Introduction
      • Cardiac Signaling in Physiological Growth
      • Ca2+-Mediated Signaling
      • Signaling at the Plasma Membrane
      • Signaling at the Mitochondria
      • Cell-Cycle signaling, cell proliferation, and apoptosis
      • Stress, Survival, and Metabolic Signaling
      • Signaling in Cardiac Development and Aging
      • Conclusion
      • Summary
      • References
  • Section II: Pediatric Cardiology in the Post-Genomic Era

    • Chapter 4. Molecular Determinants of Cardiac Development

      • Introduction
      • Overview of Cardiac Morphogenesis
      • MicroRNAs in Cardiovascular Development
      • Conclusions
      • Summary
      • References
    • Chapter 5. Molecular Determinants of Congenital Heart Disease

      • Introduction
      • Etiology of CHD: Interplay of Genetic and Environmental Factors
      • Molecular Mechanisms of CHD
      • Syndromic CHDs Caused by Point Mutations
      • Nonsyndromic CHDs Caused by Point Mutations
      • Non-Syndromic CHD Caused by Impaired Signaling Pathways
      • Nonsyndromic CHD Caused by Poi

Details

No. of pages:
944
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780124046429
Hardcover ISBN:
9780124045996

About the Author

José Marín-García

Dr.José Marín-García, highly respected cardiologist, is the current Director of Molecular Cardiology and Neuromuscular Institute in Highland Park, NJ. He has 189 listed publications and an H-index of 30. He has written and edited Mitochondria and the heart (2005), Aging and the Heart (2008), Signaling in the Heart (2008). Heart Failure (2010), Post-Genomic Cardiology (2007), and Mitochondria and Their Role in Cardiovascular Disease (2012).

Affiliations and Expertise

Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA

Reviews

"This Second edition of Post-Genomic Cardiology (PCG) deals with what promises to be the cardiology of the future. As the role of genetic screening in cardiology is strengthened, and as research on the multiple signaling pathways involved in cardiac organogenesis and pathology progresses, this 2nd edition of PCG further attempts to integrate known facts with what is still developing and with what is slowly becoming known. New areas of interest to cardiologists and researchers include systems biology, the constructive cycle of computational model building, and experimental verification. These are capable of providing the input necessary for exciting new discoveries, including the management of diseases in a “personalized” way. The book is fascinating because it introduces a field that no one with a minimum amount of scientific interest will be able to avoid in the very near future. Extensively referenced, and thoroughly researched, this book presents well-written and organized chapters, each with a summary of the important points discussed, followed by exhaustive bibliographies. A detailed glossary clearly defines the many acronyms used throughout the book. Unquestionably, this volume will be of great interest and use to clinical and research cardiologists, pharmacologists and genetics investigators; and to students of basic sciences. Dr. Marin-Garcia - author and editor of this 2nd edition of PGC has done an outstanding job of completing this challenging task." --Dr. Daniel Shindler

"This is a great book." --Dr. A. Bayes de Luna 

"Seven years ago, I was given the opportunity to review the first edition of this book, which was published in 2007. Dr. José Marín-García has updated and revised a new edition of that work. In these 7 years, we have been witnesses to the great surge in research into the genetic and molecular bases of cardiovascular disease. The use of ‘‘omics’’ has contributed enormously to this adv